Innate immune activation in neurodegenerative disease (Q38223011)

31 August 2017

title

Innate immune activation in neurodegenerative disease (English)

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31 August 2017

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Michael T Heneka

1

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31 August 2017

Markus P Kummer

series ordinal

2

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31 August 2017

Eicke Latz

series ordinal

3

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31 August 2017

publication date

1 July 2014

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Nature Reviews Immunology

31 August 2017

published in

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31 August 2017

volume

14

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31 August 2017

issue

7

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31 August 2017

page(s)

463-477

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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

31 August 2017

cites work

1 reference

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

21 January 2018

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Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain

21 January 2018

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Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

21 January 2018

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

21 January 2018

1 reference

Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals

21 January 2018

1 reference

Synaptic pruning by microglia is necessary for normal brain development

21 January 2018

1 reference

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

21 January 2018

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Pattern of invasion of the embryonic mouse spinal cord by microglial cells at the time of the onset of functional neuronal networks.

21 January 2018

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Microglial interactions with synapses are modulated by visual experience

21 January 2018

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Microglia modulate hippocampal neural precursor activity in response to exercise and aging

21 January 2018

1 reference

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

21 January 2018

1 reference

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

21 January 2018

1 reference

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

Activation and regulation of the inflammasomes

21 January 2018

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Inflammasomes in health and disease

21 January 2018

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Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury

21 January 2018

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Pyroptotic neuronal cell death mediated by the AIM2 inflammasome.

21 January 2018

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Human astrocytes express a novel NLRP2 inflammasome.

21 January 2018

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Activation of NADPH oxidase in Alzheimer's disease brains.

21 January 2018

1 reference

Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease

21 January 2018

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Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease

21 January 2018

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Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease

21 January 2018

1 reference

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

21 January 2018

1 reference

Inflammatory process in Parkinson's disease: role for cytokines

21 January 2018

1 reference

Disruption of neuronal autophagy by infected microglia results in neurodegeneration

21 January 2018

1 reference

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

21 January 2018

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Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice

21 January 2018

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Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

21 January 2018

1 reference

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

21 January 2018

1 reference

21 January 2018

1 reference

The genetics of Alzheimer disease: back to the future

21 January 2018

1 reference

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease

21 January 2018

1 reference

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

Long-term cognitive impairment and functional disability among survivors of severe sepsis

21 January 2018

1 reference

Systemic inflammation and disease progression in Alzheimer disease

21 January 2018

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Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

21 January 2018

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Body mass index in midlife and risk of Alzheimer disease and vascular dementia

21 January 2018

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Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older

21 January 2018

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Physical activity, diet, and risk of Alzheimer disease

21 January 2018

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TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

21 January 2018

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Inflammation and Alzheimer's disease: possible role of periodontal diseases

21 January 2018

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Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease

21 January 2018

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In-vivo measurement of activated microglia in dementia

21 January 2018

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Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [¹¹C]DAA1106.

21 January 2018

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Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

21 January 2018

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

21 January 2018

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Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse

21 January 2018

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Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling

21 January 2018

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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

21 January 2018

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Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

21 January 2018

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TREM2 Variants in Alzheimer's Disease

21 January 2018

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

21 January 2018

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TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

21 January 2018

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Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

21 January 2018

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

21 January 2018

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Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

21 January 2018

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

21 January 2018

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Role of Escherichia coli curli operons in directing amyloid fiber formation

21 January 2018

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Polymerizing the fibre between bacteria and host cells: the biogenesis of functional amyloid fibres.

21 January 2018

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The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation

21 January 2018

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

21 January 2018

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

21 January 2018

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Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase

21 January 2018

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Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease

21 January 2018

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ATP mediates rapid microglial response to local brain injury in vivo

21 January 2018

1 reference

Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia.

21 January 2018

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Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease.

21 January 2018

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Mrp14 deficiency ameliorates amyloid β burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing

21 January 2018

1 reference

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.

21 January 2018

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Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

21 January 2018

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Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation

21 January 2018

1 reference

A phenotypic change but not proliferation underlies glial responses in Alzheimer disease

21 January 2018

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Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

21 January 2018

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Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

21 January 2018

1 reference

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

21 January 2018

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The role of microglia in amyloid clearance from the AD brain

21 January 2018

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

21 January 2018

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor

21 January 2018

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The molecular basis of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum

21 January 2018

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Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

21 January 2018

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Increased intrathecal inflammatory activity in frontotemporal dementia: pathophysiological implications

21 January 2018

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In vivo detection of microglial activation in frontotemporal dementia

21 January 2018

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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

21 January 2018

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

21 January 2018

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Progranulin expression in the developing and adult murine brain.

21 January 2018

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Brain progranulin expression in GRN-associated frontotemporal lobar degeneration

21 January 2018

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Mechanisms of granulin deficiency: lessons from cellular and animal models

21 January 2018

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Progranulin is a chemoattractant for microglia and stimulates their endocytic activity

21 January 2018

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Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

21 January 2018

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Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

21 January 2018

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Synaptic dysfunction in progranulin-deficient mice

21 January 2018

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[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.

21 January 2018

1 reference

Glutathione peroxidase, glial cells and Parkinson's disease

21 January 2018

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Neuroinflammation in Parkinson's disease: a target for neuroprotection?

21 January 2018

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Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

21 January 2018

1 reference

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

21 January 2018

1 reference

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

21 January 2018

1 reference

Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats

21 January 2018

1 reference

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

21 January 2018

1 reference

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

21 January 2018

1 reference

Reactive macrophages increase oxidative stress and alpha-synuclein nitration during death of dopaminergic neuronal cells in co-culture: relevance to Parkinson's disease

21 January 2018

1 reference

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

21 January 2018

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Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease

21 January 2018

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MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration

21 January 2018

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Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies

21 January 2018

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Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

21 January 2018

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Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis

21 January 2018

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Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

21 January 2018

1 reference

Onset and progression in inherited ALS determined by motor neurons and microglia

21 January 2018

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

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Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

21 January 2018

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Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.

21 January 2018

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Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

21 January 2018

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Tumor necrosis factor alpha enhances glutamatergic transmission onto spinal motoneurons.

21 January 2018

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A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function

21 January 2018

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Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

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Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis

21 January 2018

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The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice.

21 January 2018

1 reference

A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis

21 January 2018

1 reference

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

21 January 2018

1 reference

A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS: Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression

21 January 2018

1 reference

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

21 January 2018

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

21 January 2018

1 reference

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

21 January 2018

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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

21 January 2018

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Distinct neuroinflammatory profile in post-mortem human Huntington's disease.

21 January 2018

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Microglial activation in presymptomatic Huntington's disease gene carriers

21 January 2018

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Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

21 January 2018

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Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

21 January 2018

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Abnormal peripheral chemokine profile in Huntington's disease

21 January 2018

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DNA microarray analysis of striatal gene expression in symptomatic transgenic Huntington's mice (R6/2) reveals neuroinflammation and insulin associations.

21 January 2018

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Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

21 January 2018

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Mutant huntingtin impairs immune cell migration in Huntington disease.

21 January 2018

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Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

21 January 2018

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Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.

21 January 2018

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Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

21 January 2018

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

21 January 2018

1 reference

RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases

21 January 2018

1 reference

Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases.

21 January 2018

1 reference

Activated microglia in dementia with Lewy bodies.

21 January 2018

1 reference

Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies

21 January 2018

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Activated microglial cells and complement factors are unrelated to cortical Lewy bodies.

21 January 2018

1 reference

The nucleus raphe interpositus in spinocerebellar ataxia type 3 (Machado-Joseph disease).

21 January 2018

1 reference

ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

21 January 2018

1 reference

The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia

21 January 2018

1 reference

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

21 January 2018

1 reference

Protocol for the MPTP mouse model of Parkinson's disease

21 January 2018

1 reference

6-hydroxy-dopamine induced degeneration of central monoamine neurons

21 January 2018

1 reference

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

1 reference

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

1 reference

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

21 January 2018

1 reference

Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22

31 March 2020

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Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

31 March 2020

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Nitric oxide synthase and neuronal vulnerability in Parkinson's disease.

31 March 2020

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α-Synuclein Alters Toll-Like Receptor Expression

31 March 2020

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31 March 2020

Motor neurone disease

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Cortical Inflammation in Alzheimer Disease but Not Dementia With Lewy Bodies

31 March 2020

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Interleukin-1beta converting enzyme/Caspase-1 (ICE/Caspase-1) and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients

31 March 2020

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12 December 2020

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12 December 2020

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue

1 reference

12 December 2020

Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra

1 reference

12 December 2020

Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3705

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31 August 2017

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