Thrombospondin 1 (Q3822573)

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mammalian protein found in Homo sapiens
  • THBS1
  • thrombospondin-p50
  • thrombospondin-1p180
  • glycoprotein G
  • thrombospondin-1
edit
Language Label Description Also known as
English
Thrombospondin 1
mammalian protein found in Homo sapiens
  • THBS1
  • thrombospondin-p50
  • thrombospondin-1p180
  • glycoprotein G
  • thrombospondin-1

Statements

part of
molecular function
protein binding
determination method
IPI
NAS
11 references
retrieved
8 April 2019
stated in
Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
NAS
retrieved
8 April 2019
stated in
Calumenin but not reticulocalbin forms a Ca2+-dependent complex with thrombospondin-1. A potential role in haemostasis and thrombosis
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
The first draft of the endostatin interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
Extended interaction network of procollagen C-proteinase enhancer-1 in the extracellular matrix
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
Complex formation of human thrombospondin with osteonectin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
retrieved
8 April 2019
stated in
Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IPI
extracellular matrix structural constituent
determination method
IEA
ISS
RCA
9 references
retrieved
1 January 2018
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
RCA
retrieved
1 January 2018
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
RCA
retrieved
1 January 2018
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
RCA
retrieved
1 January 2018
stated in
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
RCA
retrieved
1 January 2018
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
ISS
retrieved
1 January 2018
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
1 January 2018
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
1 January 2018
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
1 January 2018
stated in
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IEA
cell component
extracellular exosome
determination method
IDA
5 references
retrieved
17 October 2017
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Protein profile of exosomes from trabecular meshwork cells
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
extracellular matrix
determination method
IDA
ISS
TAS
5 references
retrieved
17 October 2017
stated in
Thrombospondin-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
TAS
retrieved
17 October 2017
stated in
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
ISS
retrieved
17 October 2017
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
extracellular space
determination method
IDA
IEA
6 references
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
17 October 2017
stated in
Human colostrum: identification of minor proteins in the aqueous phase by proteomics
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
extracellular space
determination method
HDA
IBA
IDA
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
1 January 2018
stated in
Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
1 January 2018
stated in
Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IBA
retrieved
1 January 2018
stated in
Human colostrum: identification of minor proteins in the aqueous phase by proteomics
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
1 January 2018
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
HDA
collagen-containing extracellular matrix
determination method
HDA
ISS
TAS
7 references
retrieved
1 January 2018
stated in
Thrombospondin-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
TAS
retrieved
1 January 2018
stated in
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
ISS
retrieved
1 January 2018
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
1 January 2018
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
1 January 2018
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
1 January 2018
stated in
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
1 January 2018
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
HDA
extracellular space
determination method
HDA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
8 April 2019
stated in
Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
8 April 2019
stated in
Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
8 April 2019
stated in
Human colostrum: identification of minor proteins in the aqueous phase by proteomics
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
8 April 2019
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
HDA
collagen-containing extracellular matrix
determination method
HDA
IBA
ISS
TAS
8 references
retrieved
8 April 2019
stated in
Thrombospondin-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
TAS
retrieved
8 April 2019
stated in
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
ISS
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IBA
retrieved
8 April 2019
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
8 April 2019
stated in
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
8 April 2019
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
8 April 2019
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
HDA
retrieved
8 April 2019
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
HDA
biological process
negative regulation of angiogenesis
determination method
IDA
IEA
6 references
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
17 October 2017
stated in
Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
17 October 2017
stated in
Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996
determination method
IDA
negative regulation of angiogenesis
determination method
IBA
IDA
IEA
IMP
8 references
retrieved
8 April 2019
stated in
MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IEA
retrieved
8 April 2019
stated in
Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1
GOA
curator
UniProt
UniProt protein ID
P07996
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
8 April 2019
stated in
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
8 April 2019
stated in
Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
8 April 2019
stated in
Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996
determination method
IBA
Gene Atlas image
PBB GE THBS1 201110 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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