Mucus layers in inflammatory bowel disease (Q38229690)

31 August 2017

title

Mucus layers in inflammatory bowel disease (English)

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inflammatory bowel diseases

31 August 2017

main subject

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inflammation

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author name string

Malin E V Johansson

series ordinal

1

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31 August 2017

publication date

1 November 2014

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Inflammatory Bowel Diseases

31 August 2017

published in

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31 August 2017

volume

20

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31 August 2017

issue

11

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31 August 2017

page(s)

2124-2131

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Gel-forming mucins appeared early in metazoan evolution.

31 August 2017

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Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains

21 January 2018

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Stem cells, self-renewal, and differentiation in the intestinal epithelium

21 January 2018

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The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

21 January 2018

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Negative feedback by IRE1β optimizes mucin production in goblet cells

21 January 2018

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Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

21 January 2018

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https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

21 January 2018

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Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

21 January 2018

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Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation.

21 January 2018

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21 January 2018

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Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins

21 January 2018

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ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules

21 January 2018

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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

21 January 2018

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Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor

21 January 2018

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RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract

21 January 2018

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Immune adaptations that maintain homeostasis with the intestinal microbiota

21 January 2018

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Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

21 January 2018

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The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine

21 January 2018

1 reference

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Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

21 January 2018

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Transepithelial antigen delivery in the small intestine: different paths, different outcomes

21 January 2018

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Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals

21 January 2018

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A solvent-based fixative for electron microscopy to improve retention and visualization of the intestinal mucus blanket for probiotics studies

21 January 2018

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Host-bacterial mutualism in the human intestine

21 January 2018

1 reference

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Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota

21 January 2018

1 reference

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Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

21 January 2018

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Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins

21 January 2018

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Glycan foraging in vivo by an intestine-adapted bacterial symbiont

21 January 2018

1 reference

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Importance and regulation of the colonic mucus barrier in a mouse model of colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Immune-mediated alteration in gut physiology and its role in host defence in nematode infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

21 January 2018

1 reference

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Unifying hypothesis for inflammatory bowel disease and associated colon cancer: sticking the pieces together with sugar

21 January 2018

1 reference

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Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Sulfation of colonic mucins by N-acetylglucosamine 6-O-sulfotransferase-2 and its protective function in experimental colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

ER stress and the unfolded protein response in intestinal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Inflamed gut mucosa: downstream of interleukin-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

IL-10R polymorphisms are associated with very-early-onset ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Colorectal cancer in mice genetically deficient in the mucin Muc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FMIB.0000000000000117

10.1097/MIB.0000000000000117

21 January 2018

Identifiers

DOI

1 reference

31 August 2017

1 reference