Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus (Q38246557)

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scientific article published on 17 September 2014

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English	Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus	scientific article published on 17 September 2014

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

1 reference

Europe PubMed Central

Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Hepatitis C virus

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Jerome Deval

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Julian A Symons

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Leo Beigelman

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

publication date

17 September 2014

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Current opinion in virology

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1-7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2'-C-methylcytidine in severe combined immunodeficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3'-Deoxynucleosides. IV. Pyrimidine 3'-deoxynucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2'-ethynyl-7-deaza-adenosine triphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Substrate properties of C'-methylnucleoside triphosphates in a reaction of RNA synthesis catalyzed by Escherichia coli RNA-polymerase]

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new era of hepatitis C therapy begins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bovine viral diarrhea virus as a surrogate model of hepatitis C virus for the evaluation of antiviral agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telaprevir for retreatment of HCV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of norovirus replication by the nucleoside analogue 2'-C-methylcytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replication of hepatitis C virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common and unique features of viral RNA-dependent polymerases

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An adenosine nucleoside inhibitor of dengue virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of 2'-O,4'-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current race in the development of DAAs (direct-acting antivirals) against HCV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new synthesis of 2'-C-methylnucleosides starting from D-ribose

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/25194816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.COVIRO.2014.08.004

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25194816%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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