Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators. (Q38248879)

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16 February 2020

review article

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title

Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators (English)

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16 February 2020

1

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16 February 2020

Jay Liu

2

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16 February 2020

Bao-Liang Song

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16 February 2020

author name string

Bo-Liang Li

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16 February 2020

Catherine C Y Chang

5

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16 February 2020

Ta-Yuan Chang

6

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publication date

12 September 2014

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The Journal of Steroid Biochemistry and Molecular Biology

16 February 2020

published in

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volume

151

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page(s)

102-107

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Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness

16 February 2020

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Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal

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ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

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Steroidogenic enzymes

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Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages

6 September 2017

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6 September 2017

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Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus

6 September 2017

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Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes

6 September 2017

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Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1

6 September 2017

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Neurosteroids: biochemistry and clinical significance

6 September 2017

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Mammalian acyl-CoA:cholesterol acyltransferases

6 September 2017

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The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

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Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine

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Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes

6 September 2017

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6 September 2017

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Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro

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Detection in bovine adrenal cortex of a lipoidal substance that yields pregnenolone upon treatment with alkali

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Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies

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Acyl-coenzyme A: cholesterol acyltransferase inhibitor Avasimibe affect survival and proliferation of glioma tumor cell lines

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Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner

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Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies

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Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy

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Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice

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Formation of pregnenolone- and dehydroepiandrosterone-fatty acid esters by lecithin-cholesterol acyltransferase in human plasma high density lipoproteins.

23 June 2018

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Strain differences of neurosteroid levels in mouse brain

23 June 2018

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The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain

31 August 2018

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31 August 2018

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Biological esterification of steroids.

31 August 2018

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Differential regulation by pregnenolone sulfate of intracellular Ca2+ increase by amino acids in primary cultured rat cortical neurons

31 August 2018

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Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons

31 August 2018

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Cholesterol esters as growth regulators of lymphocytic leukaemia cells

31 August 2018

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12 December 2020

GLC/MS identification of new pregnenolone metabolites in confluent embryonic rat fibroblast cultures

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12 December 2020

Biosynthesis of lipoidal derivatives of pregnenolone and dehydroisoandrosterone by the adrenal

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12 December 2020

Human Acyl-CoA:Cholesterol Acyltransferase-1 Is a Homotetrameric Enzyme in Intact Cells andin Vitro

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12 December 2020

Steroid fatty acid esters in adrenals and plasma: effects of ACTH

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12 December 2020

A comparison of the esterification of steroids by rat lecithin:cholesterol acyltransferase and acyl coenzyme A:cholesterol acyltransferase

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12 December 2020

10.1016/J.JSBMB.2014.09.008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25218443%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25218443%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

25218443

1 reference