Early experience with tedizolid: clinical efficacy, pharmacodynamics, and resistance (Q38255366)

1 September 2017

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title

Early experience with tedizolid: clinical efficacy, pharmacodynamics, and resistance (English)

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1 September 2017

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ChEBI release 2020-05-28

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Jeffrey M Rybak

1

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1 September 2017

Kayleigh Marx

series ordinal

2

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1 September 2017

Craig A Martin

series ordinal

3

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1 September 2017

language of work or name

English

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publication date

30 September 2014

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1 September 2017

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1 September 2017

34

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1 September 2017

1198-1208

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1 September 2017

11

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Microbiological features of vancomycin in the 21st century: minimum inhibitory concentration creep, bactericidal/static activity, and applied breakpoints to predict clinical outcomes or detect resistant strains

1 September 2017

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Daptomycin nonsusceptible enterococci: an emerging challenge for clinicians

21 January 2018

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Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus

21 January 2018

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Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit.

21 January 2018

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Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges

21 January 2018

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Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.

21 January 2018

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Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci

21 January 2018

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Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections.

21 January 2018

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Pulmonary disposition of tedizolid following administration of once-daily oral 200-milligram tedizolid phosphate in healthy adult volunteers

21 January 2018

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Pharmacokinetics of tedizolid following oral administration: single and multiple dose, effect of food, and comparison of two solid forms of the prodrug

21 January 2018

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Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement

21 January 2018

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Linezolid-associated toxic optic neuropathy: a report of 2 cases

21 January 2018

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Linezolid-induced neuropathy

21 January 2018

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Linezolid-Induced anemia and thrombocytopenia

21 January 2018

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Risk factors associated with the development of thrombocytopenia in patients who received linezolid therapy

21 January 2018

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In vitro, in vivo, and clinical studies of tedizolid to assess the potential for peripheral or central monoamine oxidase interactions

21 January 2018

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Risk of serotonin syndrome with concomitant administration of linezolid and serotonin agonists

21 January 2018

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Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme

21 January 2018

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In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model

21 January 2018

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Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model

21 January 2018

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In vivo pharmacodynamics of a new oxazolidinone (linezolid)

21 January 2018

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Comparative efficacies of human simulated exposures of tedizolid and linezolid against Staphylococcus aureus in the murine thigh infection model

21 January 2018

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Pharmacodynamics of the new fluoroquinolone gatifloxacin in murine thigh and lung infection models

21 January 2018

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Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines

21 January 2018

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Impact of granulocytes on the antimicrobial effect of tedizolid in a mouse thigh infection model

21 January 2018

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Pharmacokinetics and pulmonary disposition of tedizolid and linezolid in a murine pneumonia model under variable conditions

21 January 2018

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Comparative in vivo efficacies of epithelial lining fluid exposures of tedizolid, linezolid, and vancomycin for methicillin-resistant Staphylococcus aureus in a mouse pneumonia model

21 January 2018

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Linezolid-resistant methicillin-resistant Staphylococcus aureus isolated after long-term, repeated use of linezolid

21 January 2018

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Intensive care unit dissemination of multiple clones of linezolid-resistant Enterococcus faecalis and Enterococcus faecium.

21 January 2018

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Novel and uncommon antimicrobial resistance genes in livestock-associated methicillin-resistant Staphylococcus aureus

21 January 2018

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Rapid emergence of resistance to linezolid and mutator phenotypes in Staphylococcus aureus isolates from an adult cystic fibrosis patient.

21 January 2018

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Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.

21 January 2018

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Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase

21 January 2018

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Emergence of cfr-harbouring coagulase-negative staphylococci among patients receiving linezolid therapy in two hospitals in China.

21 January 2018

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Characterization and monitoring of linezolid-resistant clinical isolates of Staphylococcus epidermidis in an intensive care unit 4 years after an outbreak of infection by cfr-mediated linezolid-resistant Staphylococcus aureus

21 January 2018

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Presence and dissemination of the multiresistance gene cfr in Gram-positive and Gram-negative bacteria

21 January 2018

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Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers

21 January 2018

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Antimicrobial Resistance: Pharmacokinetics‐Pharmacodynamics of Antimicrobial Therapy: It’s Not Just for Mice Anymore

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PHAR.1491

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1 September 2017

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