Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations. (Q41862729)

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scientific article published on 13 September 2010

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English	Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.	scientific article published on 13 September 2010

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13 February 2020

Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations (English)

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13 February 2020

Staphylococcus aureus

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13 February 2020

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Jeffrey B Locke

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13 February 2020

John Finn

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Mark Hilgers

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Gracia Morales

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Shahad Rahawi

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Kedar G C

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Juan José Picazo

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Weonbin Im

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Jeffrey L Stein

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13 September 2010

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Antimicrobial Agents and Chemotherapy

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5337-5343

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13 February 2020

Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.

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5 June 2018

Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus

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5 June 2018

The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics

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5 June 2018

Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.

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5 June 2018

Polyphyletic emergence of linezolid-resistant staphylococci in the United States

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5 June 2018

Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.

1 reference

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5 June 2018

Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).

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5 June 2018

ZAAPS International Surveillance Program (2007) for linezolid resistance: results from 5591 Gram-positive clinical isolates in 23 countries

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5 June 2018

Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci

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5 June 2018

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

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5 June 2018

Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr

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5 June 2018

Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics

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5 June 2018

Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics

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5 June 2018

In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.

1 reference

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5 June 2018

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

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5 June 2018

R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance

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5 June 2018

Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit

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5 June 2018

First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States

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5 June 2018

Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections

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5 June 2018

In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens

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5 June 2018

Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors

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5 June 2018

Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase

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5 June 2018

New oxazolidinones

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5 June 2018

AM-7359--a novel oxazolidinone with low resistance potential and potent activity against drug resistant pathogens

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5 June 2018

Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity

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5 June 2018

The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics

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5 June 2018

Recent developments in the identification of novel oxazolidinone antibacterial agents

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5 June 2018

Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus

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5 June 2018

Enterococcus faecalis resistant to linezolid: case series and review of the literature

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5 June 2018

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

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5 June 2018

In vitro activities of DA-7867, a novel oxazolidinone, against recent clinical isolates of aerobic and anaerobic bacteria

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5 June 2018

Oxazolidinone Structure–Activity Relationships Leading to Linezolid

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5 June 2018

Structural insight into the role of the ribosomal tunnel in cellular regulation

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5 June 2018

Structural basis for the antibiotic activity of ketolides and azalides

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Linezolid: its role in the treatment of gram-positive, drug-resistant bacterial infections

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5 June 2018

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

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5 June 2018

The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria

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5 June 2018

Evaluation of Alamar colorimetric broth microdilution susceptibility testing method for staphylococci and enterococci

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5 June 2018

Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity

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5 June 2018

Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections

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5 June 2018

Oxazolidinones, a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and DuP 721

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5 June 2018

Zyvox Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008.

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18 August 2018

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18 August 2018

TR-700 in vitro activity against and resistance mutation frequencies among Gram-positive pathogens

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18 August 2018

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18 August 2018

Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid

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18 August 2018

The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.

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18 August 2018

A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

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Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

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18 August 2018

Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A.

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18 August 2018

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18 August 2018

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18 August 2018

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Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones

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18 August 2018

Linezolid resistance in clinical isolates of Staphylococcus aureus

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18 August 2018

Linezolid resistance in a clinical isolate of Staphylococcus aureus

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18 August 2018

Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid

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18 August 2018

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18 August 2018

Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 1. The "B" group

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12 December 2020

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Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 2. The "A" group

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12 December 2020

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Antibacterials. synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 4. Multiply-substituted aryl derivatives

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12 December 2020

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Improved method for electroporation of Staphylococcus aureus

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Novel substituted (pyridin-3-yl)phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility

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12 December 2020

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10.1128/AAC.00663-10

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13 February 2020

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13 February 2020

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13 February 2020

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