25-Hydroxycholesterols in innate and adaptive immunity (Q38260971)

1 September 2017

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title

25-Hydroxycholesterols in innate and adaptive immunity (English)

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1 September 2017

Jason G Cyster

1

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1 September 2017

Eric V Dang

series ordinal

2

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1 September 2017

Andrea Reboldi

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3

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1 September 2017

Tangsheng Yi

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4

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1 September 2017

language of work or name

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17 October 2014

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Nature Reviews Immunology

1 September 2017

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1 September 2017

14

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1 September 2017

11

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1 September 2017

731-743

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https://scigraph.springernature.com/pub.10.1038/nri3755

1 September 2017

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25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

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Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons

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Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophages

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The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response

31 March 2020

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Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

31 March 2020

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Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses

31 March 2020

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EBI2 mediates B cell segregation between the outer and centre follicle

31 March 2020

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Oxysterols direct immune cell migration via EBI2

31 March 2020

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Oxysterols direct B-cell migration through EBI2

31 March 2020

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ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation

31 March 2020

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25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

31 March 2020

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25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells.

31 March 2020

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Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

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The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

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EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

31 March 2020

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cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

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Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses

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31 March 2020

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Sterols and oxysterols in immune cell function

31 March 2020

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31 March 2020

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Cholesterol manipulation by West Nile virus perturbs the cellular immune response

31 March 2020

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Cholesterol biosynthesis modulation regulates dengue viral replication

31 March 2020

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Impaired cholesterol biosynthesis in a neuronal cell line persistently infected with measles virus

31 March 2020

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The major cellular sterol regulatory pathway is required for Andes virus infection

31 March 2020

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Cholesterol removal by methyl-beta-cyclodextrin inhibits poliovirus entry.

31 March 2020

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Cholesterol enhances mouse hepatitis virus-mediated cell fusion

31 March 2020

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Cholesterol is required for infection by Semliki Forest virus

31 March 2020

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Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis

31 March 2020

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25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

31 March 2020

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Systematic identification of type I and type II interferon-induced antiviral factors

31 March 2020

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Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro

31 March 2020

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Nonlinear partial differential equations and applications: Genomic analysis of the host response to hepatitis C virus infection

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Oxysterol-binding protein family I is the target of minor enviroxime-like compounds.

31 March 2020

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Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions

31 March 2020

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25-Hydroxycholesterol increases the availability of cholesterol in phospholipid membranes

31 March 2020

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Cholesterol sensing, trafficking, and esterification.

31 March 2020

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Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure.

31 March 2020

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A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP

31 March 2020

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The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry

31 March 2020

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Type I interferon: friend or foe?

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Immunomodulatory functions of type I interferons

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Type I IFN-mediated regulation of IL-1 production in inflammatory disorders.

31 March 2020

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The role of interferon-β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis - in the perspective of inflammasomes

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Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

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31 March 2020

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Sensing and reacting to microbes through the inflammasomes

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HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation

31 March 2020

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HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

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A role for geranylgeranylation in interleukin-1beta secretion

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The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency.

31 March 2020

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Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages

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The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha

31 March 2020

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27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

31 March 2020

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Chemical composition and physical state of lipid deposits in atherosclerosis.

31 March 2020

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Oxysterols and atherosclerosis

31 March 2020

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Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system

31 March 2020

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Disruption of the oxysterol 7alpha-hydroxylase gene in mice.

31 March 2020

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Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.

31 March 2020

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Editorial: 25-Hydroxycholesterol: a new life in immunology

31 March 2020

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Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

31 March 2020

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Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist

31 March 2020

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Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation

31 March 2020

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Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist

31 March 2020

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Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)

31 March 2020

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Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site

31 March 2020

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Crystal structure of a lipid G protein-coupled receptor

31 March 2020

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Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor

31 March 2020

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B cell localization: regulation by EBI2 and its oxysterol ligand

31 March 2020

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EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues

31 March 2020

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EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center

31 March 2020

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Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts.

31 March 2020

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Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses.

31 March 2020

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Stromal cell contributions to the homeostasis and functionality of the immune system.

31 March 2020

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Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles

31 March 2020

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B cell follicles and antigen encounters of the third kind

31 March 2020

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BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

31 March 2020

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B-cell-intrinsic STAT6 signaling controls germinal center formation

31 March 2020

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Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis

31 March 2020

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Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions

31 March 2020

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EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.

31 March 2020

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Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes

31 March 2020

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Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation

31 March 2020

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New insights into the cell biology of the marginal zone of the spleen

31 March 2020

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Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells.

31 March 2020

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A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

31 March 2020

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Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes

31 March 2020

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

31 March 2020

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EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells

31 March 2020

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Human macrophage activation programs induced by bacterial pathogens

31 March 2020

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Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages.

31 March 2020

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Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23.

31 March 2020

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Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees

31 March 2020

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Protein interaction for an interferon-inducible systemic lupus associated gene, IFIT1.

31 March 2020

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A genomic approach to human autoimmune diseases

31 March 2020

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Autoimmune disease complicating antiviral therapy for hepatitis C virus infection

31 March 2020

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EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency

31 March 2020

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Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus

31 March 2020

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A murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread.

31 March 2020

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

31 March 2020

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Integration of metabolism and inflammation by lipid-activated nuclear receptors

31 March 2020

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Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma

31 March 2020

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Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.

31 March 2020

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Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

31 March 2020

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Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

31 March 2020

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Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors

31 March 2020

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12 December 2020

3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured fibroblasts from patients with mevalonate kinase deficiency: differential response to lipid supplied by fetal bovine serum in tissue culture medium

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12 December 2020

The cholesterol requirement for sindbis virus entry and exit and characterization of a spike protein region involved in cholesterol dependence

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12 December 2020

Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol

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12 December 2020

The antigen presenting cells instruct plasma cell differentiation

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12 December 2020

Esterification of oxysterols in human serum: effects on distribution and cellular uptake

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12 December 2020

Inhibition of Sterol Synthesis in Cultured Mouse Cells by Cholesterol Derivatives Oxygenated in the Side Chain

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12 December 2020

Regulation of cholesterol biosynthesis and esterification by 25-hydroxycholesterol in a macrophage-like cell line: uncoupling by progesterone

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12 December 2020

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols

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12 December 2020

Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue

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12 December 2020

Identifiers

DOI

10.1038/NRI3755

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Dimensions Publication ID

1 September 2017

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