Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism (Q38265736)

1 September 2017

1 reference

title

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism (English)

1 reference

1 September 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Josiah Gerdts

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Daniel W Summers

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Aaron DiAntonio

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

0 references

publication date

1 February 2016

1 reference

1 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

89

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

449-460

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

Local axonal protection by WldS as revealed by conditional regulation of protein stability

12 June 2020

cites work

1 reference

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SARM1 activation triggers axon degeneration locally via NAD⁺ destruction

6 September 2017

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Acquired axonal degeneration and regeneration: Recent insights and clinical correlations

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Absence of SARM1 rescues development and survival of NMNAT2-deficient axons

6 September 2017

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Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.

6 September 2017

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Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.

6 September 2017

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A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury

6 September 2017

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The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

6 September 2017

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6 September 2017

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Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons.

6 September 2017

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Axonal trafficking of NMNAT2 and its roles in axon growth and survival in vivo

6 September 2017

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Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila

6 September 2017

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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

6 September 2017

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Sarm1-mediated axon degeneration requires both SAM and TIR interactions

6 September 2017

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Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis

6 September 2017

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Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death

6 September 2017

1 reference

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The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein

6 September 2017

1 reference

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SCG10 is a JNK target in the axonal degeneration pathway.

6 September 2017

1 reference

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T-cell death following immune activation is mediated by mitochondria-localized SARM.

6 September 2017

1 reference

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Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform

6 September 2017

1 reference

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Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention

6 September 2017

1 reference

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The NAD metabolome--a key determinant of cancer cell biology

6 September 2017

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Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo

6 September 2017

1 reference

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dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

6 September 2017

1 reference

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A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration

6 September 2017

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Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein

6 September 2017

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Axon degeneration in Parkinson's disease

6 September 2017

1 reference

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Axonal pathology in traumatic brain injury

6 September 2017

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Axon degeneration: Molecular mechanisms of a self-destruction pathway

6 September 2017

1 reference

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Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Structural biology of the Toll-like receptor family

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Axonal degeneration is mediated by the mitochondrial permeability transition pore.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins

6 September 2017

1 reference

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Keeping the CNS clear: glial phagocytic functions in Drosophila

6 September 2017

1 reference

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TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway

6 September 2017

1 reference

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Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

6 September 2017

1 reference

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NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death

6 September 2017

1 reference

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Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons

6 September 2017

1 reference

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The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration

6 September 2017

1 reference

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Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo

6 September 2017

1 reference

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Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide

6 September 2017

1 reference

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Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration

6 September 2017

1 reference

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

6 September 2017

1 reference

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Axon regeneration requires a conserved MAP kinase pathway.

6 September 2017

1 reference

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Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke

6 September 2017

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Mitochondrial and nuclear cross talk in cell death: parthanatos

6 September 2017

1 reference

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

6 September 2017

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The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model

6 September 2017

1 reference

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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

6 September 2017

1 reference

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MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival

6 September 2017

1 reference

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NAD+ metabolism in health and disease

6 September 2017

1 reference

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Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

6 September 2017

1 reference

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The Nudix hydrolase superfamily

6 September 2017

1 reference

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Axon degeneration mechanisms: commonality amid diversity

6 September 2017

1 reference

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A local mechanism mediates NAD-dependent protection of axon degeneration

6 September 2017

1 reference

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Axon retraction and degeneration in development and disease

6 September 2017

1 reference

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6 September 2017

The many faces of SAM

1 reference

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A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.

6 September 2017

1 reference

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

6 September 2017

1 reference

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Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response

6 September 2017

1 reference

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Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

6 September 2017

1 reference

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

6 September 2017

1 reference

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Apoptosis in the nervous system

6 September 2017

1 reference

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A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse

6 September 2017

1 reference

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Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Poly(ADP-ribose) in the cellular response to DNA damage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Pathological axonal death through a MAPK cascade that triggers a local energy deficit

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Dynamic regulation of SCG10 in regenerating axons after injury

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.

23 June 2018

1 reference

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Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

31 August 2018

1 reference

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Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin

31 August 2018

1 reference

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Rescue of peripheral and CNS axon defects in mice lacking NMNAT2.

31 August 2018

1 reference

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Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Highwire restrains synaptic growth by attenuating a MAP kinase signal.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Wld(S) mice are protected against the Parkinsonian mimetic MPTP.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Regulation of intracellular levels of NAD: a novel role for CD38.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

WldS mice are resistant to paclitaxel (taxol) neuropathy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

NAD+biosynthesis and salvage - a phylogenetic perspective

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742785

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

3 December 2018

1 reference

12 December 2020

Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease

1 reference

12 December 2020

Experiments on the Section of the Glosso-Pharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres

1 reference

12 December 2020

Loss of the compound action potential: an electrophysiological, biochemical and morphological study of early events in axonal degeneration in the C57BL/Ola mouse

1 reference

12 December 2020

10.1016/J.NEURON.2015.12.023

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

26844829

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26844829%20AND%20SRC:MED&resulttype=core&format=json