ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo. (Q38293052)

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English	ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.	scientific article

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3 January 2020

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo (English)

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author name string

Braydon L Burgess

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Pamela F Parkinson

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Margaret M Racke

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Veronica Hirsch-Reinshagen

4

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Jianjia Fan

5

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Charmaine Wong

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Louise Theroux

8

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Jeniffer Y Chan

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James Donkin

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Anna Wilkinson

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Danielle Balik

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Judes Poirier

14

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Dieter Lütjohann

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Ronald B Demattos

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Cheryl L Wellington

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publication date

26 February 2008

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3 January 2020

Journal of Lipid Research

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49

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6

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1254-1267

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3 January 2020

Cholesterol metabolism in the brain

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Apolipoprotein E: far more than a lipid transport protein

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Brain cholesterol turnover required for geranylgeraniol production and learning in mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Cholesterol and the biology of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Apolipoprotein E polymorphism and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Alzheimer's disease: genetic studies and transgenic models

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ABCA1 expression in carotid atherosclerotic plaques.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Current understanding of the metabolism and biological actions of HDL.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700481-JLR200

21 January 2018

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10.1194/JLR.M700481-JLR200

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3 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18314463%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

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