The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein (Q24296758)

positive regulation of amyloid-beta formation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Weihong Song

13

0 references

author name string

Gavin H Tansley

1

0 references

Braydon L Burgess

2

0 references

Matt T Bryan

3

0 references

Yuan Su

4

0 references

Veronica Hirsch-Reinshagen

5

0 references

Jonathan Pearce

6

0 references

Jeniffer Y Chan

7

0 references

Anna Wilkinson

8

0 references

Jeanette Evans

9

0 references

Kathryn E Naus

10

0 references

Sean McIsaac

11

0 references

Kelley Bromley

12

0 references

Hsui-Chiung Yang

14

0 references

Nan Wang

15

0 references

Ronald B DeMattos

16

0 references

Cheryl L Wellington

Journal of Lipid Research

17

0 references

language of work or name

English

0 references

publication date

May 2007

0 references

published in

0 references

volume

48

0 references

issue

5

0 references

page(s)

1022-34

0 references

cites work

Alzheimer's disease: genetic studies and transgenic models

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Cholesterol and the biology of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Complete characterization of the human ABC gene family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

ABC transporters in cellular lipid trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Genomic sequence and structure of the human ABCG1 (ABC8) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

The DNA sequence of human chromosome 21

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Molecular genetic approach to the characterization of the "Down syndrome region" of chromosome 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Down syndrome phenotypes: the consequences of chromosomal imbalance

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Down syndrome and Alzheimer's disease: a link between development and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Molecular mapping of Alzheimer-type dementia in Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Full genome screen for Alzheimer disease: Stage II analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

ABCA1 expression in carotid atherosclerotic plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and a

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Evidence against the overexpression of APP in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Gene expression variation and expression quantitative trait mapping of human chromosome 21 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

7 January 2021

Transcriptome analysis of human autosomal trisomy

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

7 January 2021

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

7 January 2021

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

7 January 2021

Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M600542-JLR200

7 January 2021