Vitamin D receptor, a tumor suppressor in skin (Q38307555)

2 September 2017

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title

Vitamin D receptor, a tumor suppressor in skin (English)

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2 September 2017

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Daniel D Bikle

1

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2 September 2017

8 December 2014

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Canadian Journal of Physiology and Pharmacology

2 September 2017

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2 September 2017

93

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2 September 2017

5

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2 September 2017

349-354

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Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

2 September 2017

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

H19 mRNA-like noncoding RNA promotes breast cancer cell proliferation through positive control by E2F1

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

DNA lesions induced by UV A1 and B radiation in human cells: comparative analyses in the overall genome and in the p53 tumor suppressor gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Regulation of E-cadherin and beta-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Vitamin D and the skin: Physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Tumor Necrosis Factor-α Regulation of 1,25-Dihydroxy vitamin D Production by Human Keratinocytes*

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Calcium regulation of keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinoma in relation to p53 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Activation of expression of hedgehog target genes in basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

A common human skin tumour is caused by activating mutations in beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Skin cancer prevention: a possible role of 1,25dihydroxyvitamin D3 and its analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Human cancer long non-coding RNA transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Basal cell carcinomas in mice overexpressing Gli2 in skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

21 January 2018

Cancer statistics, 2001

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The hallmarks of cancer: a long non-coding RNA point of view.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Transcription-coupled repair and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Ultraviolet radiation and skin cancer: molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

LncRNA: a new player in 1α, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

1α,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Long Noncoding RNAs: Insights from Biological Features and Functions to Diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The H19 non-coding RNA is essential for human tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Long noncoding RNAs in cell and developmental biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Preferential DNA repair of an active gene in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Long non-coding RNAs: insights into functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Expression profiling of vitamin D treated primary human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The UV response of the skin: a review of the MAPK, NFkappaB and TNFalpha signal transduction pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Basal cell carcinomas in mice overexpressing sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

PTCH mutations in squamous cell carcinoma of the skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Expression of Frizzled genes in developing and postnatal hair follicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The role of the vitamin D receptor and ERp57 in photoprotection by 1α,25-dihydroxyvitamin D3

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

RNA SHAPE analysis in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Keratinocyte-specific transglutaminase of cultured human epidermal cells: relation to cross-linked envelope formation and terminal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The role of the calcium-sensing receptor in epidermal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

DNA damage recognition during nucleotide excision repair in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

21 January 2018

Human DNA repair genes

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Cloning of the human phospholipase C-gamma1 promoter and identification of a DR6-type vitamin D-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Phospholipase C-gamma1 is required for calcium-induced keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Inhibition of 1,25-dihydroxyvitamin-D-induced keratinocyte differentiation by blocking the expression of phospholipase C-gamma1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

Sunburn and p53 in the onset of skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FCJPP-2014-0367

21 January 2018

Identifiers

DOI

10.1139/CJPP-2014-0367

1 reference

2 September 2017

1 reference

PubMed ID

25559384