The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. (Q38309456)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24464130%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance (English)

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6 March 2020

2

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6 March 2020

David J Erle

10

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6 March 2020

Maureen A Su

11

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6 March 2020

author name string

Michael Waterfield

1

1 reference

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6 March 2020

Jessica T Cortez

3

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6 March 2020

Una Fan

4

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6 March 2020

Todd Metzger

5

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6 March 2020

Alexandra Greer

6

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6 March 2020

Kayla Fasano

7

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6 March 2020

Marc Martinez-Llordella

8

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6 March 2020

Joshua L Pollack

9

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6 March 2020

Mark S Anderson

12

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6 March 2020

language of work or name

English

0 references

publication date

26 January 2014

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6 March 2020

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6 March 2020

volume

15

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6 March 2020

issue

3

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6 March 2020

page(s)

258-265

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describes a project that uses

6 March 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4172453

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

6 September 2017

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Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.

6 September 2017

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CpG islands recruit a histone H3 lysine 36 demethylase

6 September 2017

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Aire's partners in the molecular control of immunological tolerance

6 September 2017

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6 September 2017

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Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

6 September 2017

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Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

6 September 2017

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The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription

6 September 2017

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Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated

6 September 2017

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Transcriptional impact of Aire varies with cell type

6 September 2017

1 reference

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Deletional tolerance mediated by extrathymic Aire-expressing cells

6 September 2017

1 reference

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Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

6 September 2017

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Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?

6 September 2017

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The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

6 September 2017

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Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

6 September 2017

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

6 September 2017

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Modifier loci condition autoimmunity provoked by Aire deficiency

6 September 2017

1 reference

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Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

6 September 2017

1 reference

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Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins

6 September 2017

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6 September 2017

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Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly

6 September 2017

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mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression

6 September 2017

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Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function

6 September 2017

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MCAF mediates MBD1-dependent transcriptional repression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

Aire regulates negative selection of organ-specific T cells

6 September 2017

1 reference

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

6 September 2017

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Projection of an immunological self shadow within the thymus by the aire protein

6 September 2017

1 reference

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The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation

6 September 2017

1 reference

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Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator

6 September 2017

1 reference

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The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

6 September 2017

1 reference

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Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites

6 September 2017

1 reference

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Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment

6 September 2017

1 reference

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

6 September 2017

1 reference

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Positional cloning of the APECED gene

6 September 2017

1 reference

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DEAF-1, a novel protein that binds an essential region in a Deformed response element

6 September 2017

1 reference

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Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

Methylation-dependent and -independent genomic targeting principles of the MBD protein family.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

The cellular mechanism of Aire control of T cell tolerance.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172453

3 December 2018

Identifiers

DOI

10.1038/NI.2820

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24464130%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24464130%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24464130%20AND%20SRC:MED&resulttype=core&format=json