Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC. (Q38315128)

2 September 2017

Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC. (English)

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2 September 2017

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Mohamed A El-Mahdy

1

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2 September 2017

Qianzheng Zhu

2

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2 September 2017

Qi-en Wang

3

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2 September 2017

Gulzar Wani

4

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2 September 2017

Mette Praetorius-Ibba

5

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2 September 2017

Altaf A Wani

6

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2 September 2017

language of work or name

English

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publication date

8 March 2006

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

281

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2 September 2017

19

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2 September 2017

13404-13411

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Molecular mechanism of nucleotide excision repair.

2 September 2017

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Genome maintenance mechanisms for preventing cancer

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Nucleotide excision repair syndromes: molecular basis and clinical symptoms

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Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes

21 January 2018

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A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex

21 January 2018

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Nucleotide excision repair: from E. coli to man.

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The comings and goings of nucleotide excision repair factors on damaged DNA

21 January 2018

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Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair

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Sequential assembly of the nucleotide excision repair factors in vivo

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Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

21 January 2018

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Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA

21 January 2018

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p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity

21 January 2018

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Reinvestigation of the classification of five cell strains of xeroderma pigmentosum group E with reclassification of three of them.

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Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype

21 January 2018

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Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation

21 January 2018

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True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.

21 January 2018

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Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites

21 January 2018

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Characterization of DNA recognition by the human UV-damaged DNA-binding protein

21 January 2018

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An ultraviolet light-damaged DNA recognition protein absent in xeroderma pigmentosum group E cells binds selectively to pyrimidine (6-4) pyrimidone photoproducts

21 January 2018

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Reconstitution of human DNA repair excision nuclease in a highly defined system

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DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.

21 January 2018

1 reference

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Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties

21 January 2018

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Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis

21 January 2018

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UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2.

21 January 2018

1 reference

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Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A.

21 January 2018

1 reference

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In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product

21 January 2018

1 reference

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The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions.

21 January 2018

1 reference

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UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation

21 January 2018

1 reference

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The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells

21 January 2018

1 reference

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The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblasts

21 January 2018

1 reference

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DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex

21 January 2018

1 reference

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

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The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

21 January 2018

1 reference

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Cullin 4A associates with the UV-damaged DNA-binding protein DDB

21 January 2018

1 reference

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Modulation of (+/-)-anti-BPDE mediated p53 accumulation by inhibitors of protein kinase C and poly(ADP-ribose) polymerase

21 January 2018

1 reference

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Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage

21 January 2018

1 reference

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Mammalian DNA nucleotide excision repair reconstituted with purified protein components.

21 January 2018

1 reference

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The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

21 January 2018

1 reference

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DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair

21 January 2018

1 reference

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Cellular ubiquitination and proteasomal functions positively modulate mammalian nucleotide excision repair

21 January 2018

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UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

21 January 2018

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The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription

21 January 2018

1 reference

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Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.

21 January 2018

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DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M511834200

1 reference

2 September 2017

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