Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites (Q38317596)

2 September 2017

Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites (English)

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2 September 2017

L Kivinen

1

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2 September 2017

M Tsubari

2

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2 September 2017

T Haapajärvi

3

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2 September 2017

M B Datto

4

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2 September 2017

X F Wang

5

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2 September 2017

M Laiho

6

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2 September 2017

language of work or name

English

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publication date

1 November 1999

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2 September 2017

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2 September 2017

18

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2 September 2017

46

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2 September 2017

6252-6261

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203000

2 September 2017

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Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

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The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells

21 January 2018

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Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

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Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

21 January 2018

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Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

21 January 2018

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Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

21 January 2018

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Role of the CCAAT/enhancer binding protein-alpha transcription factor in the glucocorticoid stimulation of p21waf1/cip1 gene promoter activity in growth-arrested rat hepatoma cells

21 January 2018

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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

21 January 2018

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Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

21 January 2018

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

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Cellular ras activity is required for passage through multiple points of the G0/G1 phase in BALB/c 3T3 cells

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme

21 January 2018

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In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes.

21 January 2018

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Activation of the p21(Waf1/Cip1) promoter by the ets oncogene family transcription factor E1AF.

21 January 2018

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A new technique for the assay of infectivity of human adenovirus 5 DNA

21 January 2018

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p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle

21 January 2018

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Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression

21 January 2018

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New functional activities for the p21 family of CDK inhibitors

21 January 2018

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

21 January 2018

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Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites

21 January 2018

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Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

21 January 2018

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Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation

21 January 2018

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Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

21 January 2018

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

21 January 2018

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Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation

21 January 2018

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The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

21 January 2018

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

21 January 2018

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Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300.

21 January 2018

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Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

21 January 2018

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U.V.C.-induction of p53 activation and accumulation is dependent on cell cycle and pathways involving protein synthesis and phosphorylation

21 January 2018

1 reference

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Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins

21 January 2018

1 reference

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Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation

21 January 2018

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Posttranscriptional stabilization underlies p53-independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

21 January 2018

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21 January 2018

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Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

21 January 2018

1 reference

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Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

Involvement of p21(WAF1/Cip1), CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

21 January 2018

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A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

7 January 2021

Glucocorticoids stimulate p21 gene expression by targeting multiple transcriptional elements within a steroid responsive region of the p21waf1/cip1 promoter in rat hepatoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

7 January 2021

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

7 January 2021

Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203000

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203000

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Dimensions Publication ID

2 September 2017

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1 reference