IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. (Q38326038)

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12 January 2020

title

IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome (English)

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12 January 2020

3

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12 January 2020

Kiichiro Tsuchiya

6

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12 January 2020

9

Mamoru Watanabe

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12 January 2020

author name string

Shin Namiki

1

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12 January 2020

Tetsuya Nakamura

2

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12 January 2020

Motomi Yamazaki

4

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12 January 2020

Yuko Sekine

5

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12 January 2020

Ryuichi Okamoto

7

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12 January 2020

Takanori Kanai

8

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12 January 2020

language of work or name

English

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publication date

20 April 2005

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12 January 2020

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12 January 2020

volume

579

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12 January 2020

issue

13

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12 January 2020

page(s)

2781-2787

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

12 January 2020

cites work

1 reference

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Proteasome and peptidase function in MHC-class-I-mediated antigen presentation

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Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

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Proteasomes are regulated by interferon gamma: implications for antigen processing

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Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma

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Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.

21 January 2018

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Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity.

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Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes

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Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits

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Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice.

21 January 2018

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Different requirements for signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 in the regulation of low molecular mass polypeptide 2 and transporter associated with antigen processing 1 gene expression.

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Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1.

21 January 2018

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Interferon regulatory factor 1 mediates the interferon-gamma induction of the human immunoproteasome subunit multicatalytic endopeptidase complex-like 1.

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IRF family of transcription factors as regulators of host defense

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Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.

21 January 2018

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In vivo assembly of the proteasomal complexes, implications for antigen processing

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STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages

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The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro

21 January 2018

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Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface

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21 January 2018

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Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

21 January 2018

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MHC class I expression in mice lacking the proteasome subunit LMP-7

21 January 2018

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MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

21 January 2018

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