A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. (Q38327215)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

K M Bompiani

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

F C Church

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

B A Sullenger

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

publication date

1 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

Journal of Thrombosis and Haemostasis

24 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

870-880

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase

24 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Development of universal antidotes to control aptamer activity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Crystal structure of an RNA aptamer bound to thrombin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

The role of thrombin exosites I and II in the activation of human coagulation factor V.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Exosites in the substrate specificity of blood coagulation reactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

RNA aptamers as reversible antagonists of coagulation factor IXa.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Generation of species cross-reactive aptamers using "toggle" SELEX.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

A cell-based model of hemostasis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Blocking the initiation of coagulation by RNA aptamers to factor VIIa

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Effect of oligodeoxynucleotide thrombin aptamer on thrombin inhibition by heparin cofactor II and antithrombin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Thrombin signalling and protease-activated receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

A double-filter method for nitrocellulose-filter binding: application to protein-nucleic acid interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Pilot study of the efficacy of a thrombin inhibitor for use during cardiopulmonary bypass

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

A rapid method to isolate platelets from human blood by density gradient centrifugation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Proexosite-1 on Prothrombin Is a Factor Va-dependent Recognition Site for the Prothrombinase Complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

A player of many parts: the spotlight falls on thrombin's structure.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Long range communication between exosites 1 and 2 modulates thrombin function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Alpha-thrombin-catalyzed hydrolysis of fibrin I. Alternative binding modes and the accessibility of the active site in fibrin I-bound alpha-thrombin

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Allosteric changes in thrombin's activity produced by peptides corresponding to segments of natural inhibitors and substrates

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Proteolytic formation of either of the two prothrombin activation intermediates results in formation of a hirugen-binding site

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential

23 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

31 August 2018

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2012.04679.X

Preparation and properties of serum and plasma proteins; the conversion of human fibrinogen to fibrin under various conditions

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

Bothrojaracin, a proexosite I ligand, inhibits factor Va-accelerated prothrombin activation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636572

The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity

31 August 2018

1 reference

12 December 2020

Cleavage requirements for activation of factor V by factor Xa

1 reference

12 December 2020

Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers

1 reference

12 December 2020

Anticoagulant therapy during cardiopulmonary bypass

1 reference

12 December 2020

Characterization of proexosite I on prothrombin

1 reference

12 December 2020

Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation

1 reference

12 December 2020

Molecular mapping of thrombin-receptor interactions

1 reference

12 December 2020

Multiple active forms of thrombin. I. Partial resolution, differential activities, and sequential formation

1 reference

12 December 2020

1 reference

12 December 2020

Evidence for essential lysines in heparin cofactor II

1 reference

12 December 2020

10.1111/J.1538-7836.2012.04679.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

22385910

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22385910%20AND%20SRC:MED&resulttype=core&format=json