cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control (Q38335069)

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English	cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Ornithine carbamoyltransferase

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cross-pathway control protein 1

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guanine nucleotide-binding protein subunit beta-like protein

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Neurospora crassa

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based on heuristic

inferred from title

author name string

Sattlegger E

1

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Hinnebusch AG

2

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Barthelmess IB

3

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Europe PubMed Central

PubMed publication ID

2 September 2017

language of work or name

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publication date

1 August 1998

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Europe PubMed Central

PubMed publication ID

2 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

2 September 2017

273

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Europe PubMed Central

PubMed publication ID

2 September 2017

32

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

20404-20416

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

The cross-pathway control gene of Neurospora crassa, cpc-1, encodes a protein similar to GCN4 of yeast and the DNA-binding domain of the oncogene v-jun-encoded protein

1 reference

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The Aspergillus niger GCN4 homologue, cpcA, is transcriptionally regulated and encodes an unusual leucine zipper

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Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase

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Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

1 reference

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21 January 2018

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

1 reference

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21 January 2018

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

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Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase

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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

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Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

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Cloning and characterization of a cDNA encoding a protein synthesis initiation factor-2alpha (eIF-2alpha) kinase from Drosophila melanogaster. Homology To yeast GCN2 protein kinase

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The regulation of the protein kinase PKR by RNA.

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Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase

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eIF-2 kinases: regulators of general and gene-specific translation initiation

1 reference

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Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

1 reference

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The cpc-2 gene of Neurospora crassa encodes a protein entirely composed of WD-repeat segments that is involved in general amino acid control and female fertility.

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High-efficiency electro-transformation of Escherichia coli with DNA from ligation mixtures

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High efficiency electroporation of ligated DNA into bacteria

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Basic local alignment search tool

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cpc-1, the general regulatory gene for genes of amino acid biosynthesis in Neurospora crassa, is differentially expressed during the asexual life cycle

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

1 reference

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Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases

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The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase

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Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase

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Isolation and analysis of mutated histidyl-tRNA synthetases from Escherichia coli

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Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp)

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Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases

1 reference

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Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases

1 reference

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Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

1 reference

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Translational regulation in response to changes in amino acid availability in Neurospora crassa.

1 reference

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Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control

1 reference

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Role of the extra G-C pair at the end of the acceptor stem of tRNA(His) in aminoacylation

1 reference

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Enzymatic aminoacylation of an eight-base-pair microhelix with histidine

1 reference

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Overlapping nucleotide determinants for specific aminoacylation of RNA microhelices.

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Strategy for RNA recognition by yeast histidyl-tRNA synthetase

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Compilation of tRNA sequences and sequences of tRNA genes

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Evidence for translational regulation of the activator of general amino acid control in yeast

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A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae

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Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs

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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

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Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

1 reference

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

1 reference

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GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast

1 reference

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Calcium-dependent bacteriophage DNA infection

1 reference

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Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

1 reference

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Mutants affecting amino acid cross-pathway control inNeurospora crassa

1 reference

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Cloning of the arg-12 gene of Neurospora crassa and regulation of its transcript via cross-pathway amino acid control

1 reference

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A mutant form of ornithine transcarbamylase found in a strain of Neurospora carrying a pyrimidine-proline suppressor gene

1 reference

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Restricted activation of general amino acid control under conditions of glutamine limitation in Neurospora crassa

1 reference

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21 January 2018

Identifiers

10.1074/JBC.273.32.20404

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

ResearchGate publication ID

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