Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice (Q38335202)

2 September 2017

Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice (English)

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2 September 2017

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Kumiko Taguchi

1

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2 September 2017

Tsuneo Kobayashi

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2

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2 September 2017

Takayuki Matsumoto

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3

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2 September 2017

Katsuo Kamata

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4

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2 September 2017

13 May 2011

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American Journal of Physiology Heart and Circulatory Physiology

2 September 2017

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2 September 2017

301

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2 September 2017

2

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2 September 2017

H571-83

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Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving phosphatidylinositol 3-kinase and protein kinase C.

2 September 2017

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

A beta-arrestin 2 signaling complex mediates lithium action on behavior

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Role of nitric oxide in diabetic complications.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Endothelial dysfunction in diabetes.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Rational design and evaluation of new lead compound structures for selective betaARK1 inhibitors

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

ANG II enhances contractile responses via PI3-kinase p110 delta pathway in aortas from diabetic rats with systemic hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Tempol reduces oxidative stress and restores renal dopamine D1-like receptor- G protein coupling and function in hyperglycemic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Enhancement of mesenteric artery contraction to 5-HT depends on Rho kinase and Src kinase pathways in the ob/ob mouse model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

The inhibitory effect of 3-amino-1,2,4-triazole on relaxation induced by hydroxylamine and sodium azide but not hydrogen peroxide or glyceryl trinitrate in rat aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Physiological roles of G protein-coupled receptor kinases and arrestins

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Gender differences in the regulation of blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Molecular mechanisms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Homocysteine effects classical pathway of GPCR down regulation: Galpha(q/11), Galpha(12/13), G(i/o).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Insulin-induced vasodilatation: physiology or pharmacology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01189.2010

10.1152/AJPHEART.01189.2010

21 January 2018

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DOI

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2 September 2017

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