Mechanism of catalysis of inhibition of factor IXa by antithrombin in the presence of heparin or pentasaccharide (Q38353159)

2 September 2017

title

Mechanism of catalysis of inhibition of factor IXa by antithrombin in the presence of heparin or pentasaccharide (English)

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2 September 2017

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4

Jeffrey I Weitz

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2 September 2017

3

James C Fredenburgh

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2 September 2017

Ericka M Wiebe

1

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2 September 2017

Alan R Stafford

series ordinal

2

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2 September 2017

language of work or name

English

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publication date

27 June 2003

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

278

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2 September 2017

issue

37

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2 September 2017

page(s)

35767-35774

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Low-molecular-weight heparins

2 September 2017

cites work

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The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions

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Serpin structure, mechanism, and function

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Biochemical and pharmacological properties of SANORG 32701. Comparison with the "synthetic pentasaccharide' (SR 90107/ORG 31540) and standard heparin

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A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement

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Mechanism of factor IXa inhibition by antithrombin in the presence of unfractionated and low molecular weight heparins and fucoidan.

21 January 2018

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The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa, factor XIa, factor XIIa and kallikrein by antithrombin

21 January 2018

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Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse. Role of the endothelium and the plasma proteinase inhibitors

21 January 2018

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Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa.

21 January 2018

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Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies

21 January 2018

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Localization of a heparin binding site in the catalytic domain of factor XIa.

21 January 2018

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Hypersulfated low molecular weight heparin with reduced affinity for antithrombin acts as an anticoagulant by inhibiting intrinsic tenase and prothrombinase

21 January 2018

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Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

21 January 2018

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21 January 2018

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X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

21 January 2018

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Antibody-probed conformational transitions in the protease domain of human factor IX upon calcium binding and zymogen activation: putative high-affinity Ca(2+)-binding site in the protease domain

21 January 2018

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Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin

21 January 2018

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The use of prothrombin(S525C) labeled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation

21 January 2018

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Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.

21 January 2018

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Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols

21 January 2018

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Inhibition of bovine factor IXa and factor Xa.beta. by antithrombin III

21 January 2018

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Localization of the heparin binding exosite of factor IXa

21 January 2018

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Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding

21 January 2018

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Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human coagulation factor xa. Studies on catalytic efficiency and inhibitor binding

21 January 2018

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Interaction of factor IXa with factor VIIIa. Effects of protease domain Ca2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X

21 January 2018

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Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304803200

The inhibition of the generation of thrombin and the antithrombotic effect of a pentasaccharide with sole anti-factor Xa activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304803200

21 January 2018

Identifiers

DOI

10.1074/JBC.M304803200

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2 September 2017

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