Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism (Q38353509)

2 September 2017

title

Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism (English)

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2 September 2017

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P Gelebart

1

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2 September 2017

Z Zak

2

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2 September 2017

M Anand

3

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2 September 2017

J Dien-Bard

4

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2 September 2017

H M Amin

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2 September 2017

R Lai

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2 September 2017

publication date

4 June 2009

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2 September 2017

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2 September 2017

volume

23

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2 September 2017

issue

10

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2 September 2017

page(s)

1836-1846

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https://scigraph.springernature.com/pub.10.1038/leu.2009.100

2 September 2017

exact match

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cites work

Mantle cell lymphoma: advances in biology and therapy

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Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

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Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis

21 January 2018

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Selective Inhibition of I B Kinase Sensitizes Mantle Cell Lymphoma B Cells to TRAIL by Decreasing Cellular FLIP Level

21 January 2018

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Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma

21 January 2018

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Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels.

21 January 2018

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Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas

21 January 2018

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Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-kappaB pathways

21 January 2018

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Therapeutic options in mantle cell lymphoma

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Biology of IL-21 and the IL-21 receptor

21 January 2018

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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

21 January 2018

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The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

21 January 2018

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7 January 2021

IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses

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Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells

21 January 2018

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IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

21 January 2018

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High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

21 January 2018

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Interleukin-21 is a growth and survival factor for human myeloma cells

21 January 2018

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Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma

21 January 2018

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Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

21 January 2018

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Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells.

21 January 2018

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STAT1 as a key modulator of cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

STAT3 as a central mediator of neoplastic cellular transformation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

Apoptosis induced by BIK was decreased with RNA interference of caspase-12.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

Mutations of the BIK gene in human peripheral B-cell lymphomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

Expression of the adaptor protein hematopoietic Src homology 2 is up-regulated in response to stimuli that promote survival and differentiation of B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

Decreased levels of circulating IL-21 in HIV-infected AIDS patients: correlation with CD4+ T-cell counts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.100

7 January 2021

IL-21 induces the apoptosis of resting and activated primary B cells

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

7 January 2021

IL-21 as new therapy for CLL?

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https://api.crossref.org/works/10.1038%2FLEU.2009.100

7 January 2021

Identifiers

DOI

10.1038/LEU.2009.100

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Dimensions Publication ID

2 September 2017

1026786051

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