Tubocapsanolide A inhibits transforming growth factor-beta-activating kinase 1 to suppress NF-kappaB-induced CCR7. (Q38358496)

2 September 2017

Tubocapsanolide A inhibits transforming growth factor-beta-activating kinase 1 to suppress NF-kappaB-induced CCR7. (English)

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2 September 2017

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ChEBI release 2020-05-28

Mei-Ren Pan

1

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2 September 2017

Hui-Chiu Chang

2

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2 September 2017

Yang-Chang Wu

3

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2 September 2017

Chao-Cheng Huang

4

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2 September 2017

Wen-Chun Hung

5

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2 September 2017

language of work or name

English

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publication date

2 December 2008

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

284

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2 September 2017

5

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2 September 2017

2746-2754

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Integrity of intermediate filaments is associated with the development of acquired thermotolerance in 9L rat brain tumor cells

2 September 2017

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Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves

21 January 2018

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Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis

21 January 2018

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Effect of Withania somnifera on B16F-10 melanoma induced metastasis in mice

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Involvement of chemokine receptors in breast cancer metastasis

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The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes

21 January 2018

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Chemokine receptors and melanoma metastasis

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Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer.

21 January 2018

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Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis

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CCL21 chemokine regulates chemokine receptor CCR7 bearing malignant melanoma cells.

21 January 2018

1 reference

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A bioactive withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression.

21 January 2018

1 reference

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Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation

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HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion

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Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733

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EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy

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Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells.

21 January 2018

1 reference

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Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs

21 January 2018

1 reference

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Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression

21 January 2018

1 reference

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Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

21 January 2018

1 reference

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Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines

21 January 2018

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Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.

21 January 2018

1 reference

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MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

21 January 2018

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The essential role of MEKK3 in TNF-induced NF-kappaB activation

21 January 2018

1 reference

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

21 January 2018

1 reference

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NAK is an IkappaB kinase-activating kinase

21 January 2018

1 reference

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Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

21 January 2018

1 reference

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A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

21 January 2018

1 reference

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Ubiquitin, TAK1 and IKK: is there a connection?

21 January 2018

1 reference

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Ubiquitin-mediated activation of TAK1 and IKK.

21 January 2018

1 reference

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Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA.

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1 reference

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Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking

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21 January 2018

Identifiers

DOI

10.1074/JBC.M806223200

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2 September 2017

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