Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity (Q38363496)

2 September 2017

title

Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity (English)

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2 September 2017

Janina Cramer

1

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2 September 2017

Michael Strerath

series ordinal

2

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2 September 2017

Andreas Marx

series ordinal

3

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2 September 2017

Tobias Restle

series ordinal

4

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2 September 2017

language of work or name

English

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publication date

27 August 2002

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

277

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2 September 2017

issue

46

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2 September 2017

page(s)

43593-43598

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Fidelity of DNA synthesis

2 September 2017

cites work

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DNA replication fidelity

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The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance

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The expanding polymerase universe

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The Y-family of DNA polymerases

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Molecular insights into error-prone DNA replication and error-free lesion bypass

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Low fidelity DNA synthesis by human DNA polymerase-eta.

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DNA polymerases lose their grip.

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Hydrogen bonding revisited: geometric selection as a principal determinant of DNA replication fidelity

21 January 2018

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A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity

21 January 2018

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Active site tightness and substrate fit in DNA replication

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The accuracy of reverse transcriptase from HIV-1.

21 January 2018

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Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis.

21 January 2018

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Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

21 January 2018

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Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 January 2018

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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

21 January 2018

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The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

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Varied DNA polymerase-substrate interactions in the nucleotide binding pocket

21 January 2018

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Implications of active site constraints on varied DNA polymerase selectivity

21 January 2018

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Gel fidelity assay measuring nucleotide misinsertion, exonucleolytic proofreading, and lesion bypass efficiencies

21 January 2018

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Appendix. Gel kinetic analysis of polymerase fidelity in the presence of multiple enzyme DNA encounters

21 January 2018

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Conformational coupling in DNA polymerase fidelity

21 January 2018

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Refined model for primer/template binding by HIV-1 reverse transcriptase: pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nuc

21 January 2018

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Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

21 January 2018

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Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

21 January 2018

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Analysis of the polymerization kinetics of homodimeric EIAV p51/51 reverse transcriptase implies the formation of a polymerase active site identical to heterodimeric EIAV p66/51 reverse transcriptase

21 January 2018

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Pre-steady-state kinetic characterization of RNA-primed initiation of transcription by HIV-1 reverse transcriptase and analysis of the transition to a processive DNA-primed polymerization mode

21 January 2018

1 reference

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Choosing the right sugar: how polymerases select a nucleotide substrate

21 January 2018

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Error-Prone DNA Polymerases

21 January 2018

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The anatomy of infidelity

21 January 2018

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Getting a grip on how DNA polymerases function

21 January 2018

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Mimicking the Structure and Function of DNA: Insights into DNA Stability and Replication

21 January 2018

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Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase

21 January 2018

1 reference

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DNA Polymerase Selectivity: Sugar Interactions Monitored with High-Fidelity Nucleotides This work was supported by a grant from the Deutsche Forschungsgemeinschaft. We thank Professor Dr. Michael Famulok for his continuing support

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207854200

Replication of non-hydrogen bonded bases by DNA polymerases: a mechanism for steric matching

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207854200

21 January 2018

Identifiers

DOI

10.1074/JBC.M207854200

1 reference

2 September 2017

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