Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation (Q38363901)

2 September 2017

Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation (English)

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2 September 2017

Lin Wang

1

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2 September 2017

William A Rudert

2

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2 September 2017

Inna Loutaev

3

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2 September 2017

Vera Roginskaya

4

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2 September 2017

Seth J Corey

5

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2 September 2017

language of work or name

English

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publication date

1 August 2002

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2 September 2017

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2 September 2017

21

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2 September 2017

34

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2 September 2017

5346-5355

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205670

2 September 2017

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cites work

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A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

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Cbl-b regulates the CD28 dependence of T-cell activation.

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Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases

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Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor.

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Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia

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Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase

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Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation

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cbl-b inhibits epidermal growth factor receptor signaling

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Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

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The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk.

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Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.

21 January 2018

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Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl

21 January 2018

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Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl

21 January 2018

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Tyrosine kinase activation in the decision between growth, differentiation, and death responses initiated from the B cell antigen receptor

21 January 2018

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The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases

21 January 2018

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation

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cbl-3: a new mammalian cbl family protein

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Molecular cloning and characterization of a novel cbl-family gene, cbl-c

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Use of gene knockouts in cultured cells to study apoptosis

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Cbl: complex formation and functional implications

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The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

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A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

21 January 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 January 2018

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

21 January 2018

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A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

21 January 2018

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Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

21 January 2018

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Jak2 is essential for signaling through a variety of cytokine receptors

21 January 2018

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Negative regulation of Lck by Cbl ubiquitin ligase

21 January 2018

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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

21 January 2018

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Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways

21 January 2018

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Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)

21 January 2018

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Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase

21 January 2018

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Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl.

21 January 2018

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Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

21 January 2018

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RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

21 January 2018

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

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Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling

21 January 2018

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Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding

21 January 2018

1 reference

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Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

21 January 2018

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

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Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages

21 January 2018

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7 January 2021

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205670

7 January 2021

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205670

7 January 2021

Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205670

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Dimensions Publication ID

2 September 2017

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