RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia (Q38367298)

2 September 2017

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia (English)

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2 September 2017

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Elli Papaemmanuil

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Sarah O'Meara

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Melvyn Greaves

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Mel Greaves

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Ludmil B Alexandrov

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David C. Wedge

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David C Wedge

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Keiran Raine

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Keiran Raine

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Andrew Menzies

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Serena Nik-Zainal

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Jon W Teague

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Michael R Stratton

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David R Jones

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John Marshall

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Jan Zuna

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Manasa Ramakrishna

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Inmaculada Rapado

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Yilong Li

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Nicola E Potter

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Jose Tubio

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Susanna L Cooke

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Inigo Martincorena

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Jonathan Hinton

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Gunes Gundem

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Frederik W van Delft

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Ian Titley

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Lucy Stebbings

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Catherine Leroy

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John Gamble

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Ben Robinson

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Laura Mudie

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Adam P Butler

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Giovanni Cazzaniga

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Andrea Biondi

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language of work or name

English

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publication date

12 January 2014

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https://scigraph.springernature.com/pub.10.1038/ng.2874

2 September 2017

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6 September 2017

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6 September 2017

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Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells

6 September 2017

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Mutational processes molding the genomes of 21 breast cancers

6 September 2017

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Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

6 September 2017

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The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution

6 September 2017

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

6 September 2017

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ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy.

6 September 2017

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V(D)J recombination: mechanisms of initiation

6 September 2017

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The genomic complexity of primary human prostate cancer

6 September 2017

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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

6 September 2017

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

6 September 2017

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The patterns and dynamics of genomic instability in metastatic pancreatic cancer

6 September 2017

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Allele-specific copy number analysis of tumors

6 September 2017

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6 September 2017

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Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia

6 September 2017

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Complex landscapes of somatic rearrangement in human breast cancer genomes

6 September 2017

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6 September 2017

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Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes

6 September 2017

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6 September 2017

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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

6 September 2017

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Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Origins of chromosome translocations in childhood leukaemia

6 September 2017

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RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

6 September 2017

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Chromosome translocations and covert leukemic clones are generated during normal fetal development

6 September 2017

1 reference

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Genetic variegation of clonal architecture and propagating cells in leukaemia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3960636

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNG.2874

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNG.2874

Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2 by juxtaposition with MBNL1 and STAG2

21 January 2018

1 reference

12 December 2020

An investigation of the t(12;21) rearrangement in children with B-precursor acute lymphoblastic leukaemia using cytogenetic and molecular methods

1 reference

12 December 2020

Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia

1 reference

12 December 2020

V(D)J recombination: a functional definition of the joining signals

1 reference

12 December 2020

Attack of the CD4 clones

1 reference

12 December 2020

Identifiers

DOI

10.1038/NG.2874

1 reference

2 September 2017

1 reference

2 September 2017

1 reference