Targeting PTEN using small molecule inhibitors (Q38369369)

2 September 2017

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title

Targeting PTEN using small molecule inhibitors (English)

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2 September 2017

Lok Hang Mak

1

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PubMed ID

25747336

2 September 2017

Rudiger Woscholski

series ordinal

2

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2 September 2017

4 March 2015

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2 September 2017

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2 September 2017

77-78

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2 September 2017

63-68

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

2 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

The multiple roles of PTEN in tumor suppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Activation of p70 S6 kinase and erk-encoded mitogen-activated protein kinases is resistant to high cyclic nucleotide levels in Swiss 3T3 fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Targeting cancer with small molecule kinase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Bisperoxovanadium compounds are potent PTEN inhibitors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

The assessment of PTEN tumor suppressor gene in combination with Gleason scoring and serum PSA to evaluate progression of prostate carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Inhibition of the phosphatase PTEN protects mice against oleic acid-induced acute lung injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

The safe use of a PTEN inhibitor for the activation of dormant mouse primordial follicles and generation of fertilizable eggs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

PTEN inhibitors cause a negative inotropic and chronotropic effect in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

PTEN and myotubularin: novel phosphoinositide phosphatases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Protein tyrosine phosphatase 1B inhibitors for diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

A small molecule mimicking a phosphatidylinositol (4,5)-bisphosphate binding pleckstrin homology domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

AKT/PKB signaling: navigating downstream

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Characterisation of the PTEN inhibitor VO-OHpic

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Protein Lipid Overlay Assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphos

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.007

10.1016/J.YMETH.2015.02.007

7 January 2021

Identifiers

DOI

1 reference

2 September 2017

1 reference

PubMed ID

25747336