Protein tyrosine phosphatase 1B inhibitors for diabetes (Q34810384)

4 August 2017

1 reference

title

Protein tyrosine phosphatase 1B inhibitors for diabetes (English)

1 reference

4 August 2017

Theodore O Johnson

1

1 reference

PubMed ID

12209150

4 August 2017

Jacques Ermolieff

series ordinal

2

1 reference

PubMed ID

12209150

4 August 2017

Michael R Jirousek

series ordinal

3

1 reference

4 August 2017

1 September 2002

1 reference

Nature Reviews Drug Discovery

4 August 2017

1 reference

4 August 2017

1

1 reference

4 August 2017

696-709

1 reference

4 August 2017

9

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd895

4 August 2017

0 references

cites work

Global and societal implications of the diabetes epidemic

1 reference

Prevalence of impaired glucose tolerance among children and adolescents with marked obesity

31 March 2020

1 reference

Childhood obesity and a diabetes epidemic

31 March 2020

1 reference

The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study

31 March 2020

1 reference

The dysmetabolic syndrome

31 March 2020

1 reference

Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development

31 March 2020

1 reference

Clinical characterization of insulin secretion as the basis for genetic analyses

31 March 2020

1 reference

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

31 March 2020

1 reference

Beyond postprandial hyperglycaemia: metabolic factors associated with cardiovascular disease

31 March 2020

1 reference

Unraveling the causes of diabetes

31 March 2020

1 reference

Insulin signalling and the regulation of glucose and lipid metabolism

31 March 2020

1 reference

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

31 March 2020

1 reference

Insulin signaling pathways in time and space.

31 March 2020

1 reference

Regulated transport of the glucose transporter GLUT4

31 March 2020

1 reference

Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance--is insulin resistance initiated in the adipose tissue?

31 March 2020

1 reference

Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

31 March 2020

1 reference

Coordinated action of protein tyrosine phosphatases in insulin signal transduction

31 March 2020

1 reference

Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

31 March 2020

1 reference

Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus

31 March 2020

1 reference

Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes.

31 March 2020

1 reference

A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree

31 March 2020

1 reference

A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance

31 March 2020

1 reference

A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro

31 March 2020

1 reference

Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance

31 March 2020

1 reference

Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities

31 March 2020

1 reference

Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells

31 March 2020

1 reference

Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

31 March 2020

1 reference

Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation

31 March 2020

1 reference

Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes

31 March 2020

1 reference

Insulin stimulates tyrosine phosphorylation and inactivation of protein-tyrosine phosphatase 1B in vivo

31 March 2020

1 reference

Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2

31 March 2020

1 reference

The mechanism of protein kinase regulation by protein phosphatases

31 March 2020

1 reference

Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant

31 March 2020

1 reference

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

31 March 2020

1 reference

Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum

31 March 2020

1 reference

31 March 2020

A pit stop at the ER.

1 reference

Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains

31 March 2020

1 reference

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

31 March 2020

1 reference

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

31 March 2020

1 reference

PTP1B regulates leptin signal transduction in vivo

31 March 2020

1 reference

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity

31 March 2020

1 reference

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

31 March 2020

1 reference

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

31 March 2020

1 reference

Crystal structure of human protein tyrosine phosphatase 1B

31 March 2020

1 reference

Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

31 March 2020

1 reference

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics

31 March 2020

1 reference

Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography

31 March 2020

1 reference

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

31 March 2020

1 reference

Discovering high-affinity ligands for proteins

31 March 2020

1 reference

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

31 March 2020

1 reference

The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase

31 March 2020

1 reference

Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha

31 March 2020

1 reference

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases

31 March 2020

1 reference

Structure determination of T cell protein-tyrosine phosphatase

31 March 2020

1 reference

Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation

31 March 2020

1 reference

Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice

31 March 2020

1 reference

Potent inhibition of insulin receptor dephosphorylation by a hexamer peptide containing the phosphotyrosyl mimetic F2Pmp

31 March 2020

1 reference

Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design

31 March 2020

1 reference

Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B

31 March 2020

1 reference

Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics

31 March 2020

1 reference

Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

31 March 2020

1 reference

Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action

31 March 2020

1 reference

Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B

31 March 2020

1 reference

Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity

31 March 2020

1 reference

2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

31 March 2020

1 reference

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes

31 March 2020

1 reference

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

31 March 2020

1 reference

Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.

31 March 2020

1 reference

Theoretical and practical aspects of proteinase inhibition kinetics

31 March 2020

1 reference

Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases

31 March 2020

1 reference

Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4).

31 March 2020

1 reference

Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

31 March 2020

1 reference

Interaction of trace levels of vanadium(IV) and vanadium(V) in biological systems

31 March 2020

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

1 reference

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

31 March 2020

1 reference

Molecular properties that influence the oral bioavailability of drug candidates

31 March 2020

1 reference

The Finnish Diabetes Prevention Study.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD895

1 reference

4 August 2017

1 reference

PubMed ID

12209150