A phase Ib dose-escalation study of the MEK inhibitor trametinib in combination with the PI3K/mTOR inhibitor GSK2126458 in patients with advanced solid tumors. (Q38379114)

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scientific article published on 23 July 2016

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English	A phase Ib dose-escalation study of the MEK inhibitor trametinib in combination with the PI3K/mTOR inhibitor GSK2126458 in patients with advanced solid tumors.	scientific article published on 23 July 2016

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19 March 2020

A phase Ib dose-escalation study of the MEK inhibitor trametinib in combination with the PI3K/mTOR inhibitor GSK2126458 in patients with advanced solid tumors (English)

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19 March 2020

Philippe L. Bedard

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19 March 2020

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J E Grilley-Olson

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19 March 2020

A Fasolo

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19 March 2020

M Cornfeld

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19 March 2020

L Cartee

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19 March 2020

A R Abdul Razak

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19 March 2020

L-A Stayner

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19 March 2020

Y Wu

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19 March 2020

R Greenwood

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19 March 2020

R Singh

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19 March 2020

C B Lee

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19 March 2020

J Bendell

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19 March 2020

H A Burris

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19 March 2020

G Del Conte

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19 March 2020

C Sessa

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19 March 2020

J R Infante

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19 March 2020

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23 July 2016

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19 March 2020

Investigational New Drugs

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19 March 2020

34

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19 March 2020

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19 March 2020

740-749

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19 March 2020

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance

1 reference

https://api.crossref.org/works/10.1007%2FS10637-016-0377-0

21 January 2018

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 reference

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21 January 2018

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

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21 January 2018

In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

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21 January 2018

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

1 reference

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21 January 2018

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

1 reference

https://api.crossref.org/works/10.1007%2FS10637-016-0377-0

21 January 2018

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

1 reference

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21 January 2018

Circulating mutant DNA to assess tumor dynamics

1 reference

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21 January 2018

A Bayesian dose-finding design for drug combination clinical trials based on the logistic model.

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21 January 2018

Flexible Bayesian methods for cancer phase I clinical trials. Dose escalation with overdose control

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21 January 2018

Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer

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21 January 2018

Phase I study of the MEK inhibitor trametinib in combination with the AKT inhibitor afuresertib in patients with solid tumors and multiple myeloma.

1 reference

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21 January 2018

Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition

1 reference

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21 January 2018

Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee

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21 January 2018

A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors

1 reference

https://api.crossref.org/works/10.1007%2FS10637-016-0377-0

21 January 2018

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