Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function (Q38400509)

2 September 2017

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title

Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function (English)

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2 September 2017

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Helle S. Waagepetersen

series ordinal

3

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2 September 2017

1

Leif Hertz

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2 September 2017

Ye Chen

2

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PubMed ID

25832906

2 September 2017

language of work or name

English

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publication date

23 April 2015

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Journal of Neurochemistry

2 September 2017

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2 September 2017

134

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2 September 2017

7-20

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2 September 2017

1

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Activation of PARP by oxidative stress induced by β-amyloid: implications for Alzheimer's disease

2 September 2017

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Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

21 January 2018

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Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease.

21 January 2018

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In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death

21 January 2018

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Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

21 January 2018

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The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation.

21 January 2018

1 reference

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

21 January 2018

1 reference

Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo

21 January 2018

1 reference

Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells.

21 January 2018

1 reference

Amyloid-β may be released from non-junctional varicosities of axons generated from abnormal tau-containing brainstem nuclei in sporadic Alzheimer's disease: a hypothesis.

21 January 2018

1 reference

Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.

21 January 2018

1 reference

Noradrenergic regulation of glial activation: molecular mechanisms and therapeutic implications.

21 January 2018

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Mitochondrial abnormalities in Alzheimer brain: mechanistic implications

21 January 2018

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Spatial, temporal and numeric analysis of Alzheimer changes in the nucleus coeruleus.

21 January 2018

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Mitochondrial reactive oxygen species and Ca2+ signaling

21 January 2018

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Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease.

21 January 2018

1 reference

Nucleus basalis-enabled stimulus-specific plasticity in the visual cortex is mediated by astrocytes.

21 January 2018

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The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo

21 January 2018

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Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

21 January 2018

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Accumulation of amyloid precursor fragment in Alzheimer plaques

21 January 2018

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Hypometabolism as a therapeutic target in Alzheimer's disease

21 January 2018

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Changes during development in transport processes of the blood-brain barrier

21 January 2018

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Brain fuel metabolism, aging, and Alzheimer's disease

21 January 2018

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21 January 2018

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Regulation of mitochondrial dehydrogenases by calcium ions

21 January 2018

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Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

21 January 2018

1 reference

Relationship between imaging biomarkers, age, progression and symptom severity in Alzheimer's disease

21 January 2018

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Hyperphosphorylated tau in young and middle-aged subjects

21 January 2018

1 reference

Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography.

21 January 2018

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Alzheimer's disease: neurofibrillary tangles in nuclei that project to the cerebral cortex.

21 January 2018

1 reference

Importance of glutamate-generating metabolic pathways for memory consolidation in chicks

21 January 2018

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Glycogen is a preferred glutamate precursor during learning in 1-day-old chick: biochemical and behavioral evidence.

21 January 2018

1 reference

Role of beta-adrenoceptors in memory consolidation: beta3-adrenoceptors act on glucose uptake and beta2-adrenoceptors on glycogenolysis

21 January 2018

1 reference

Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease.

21 January 2018

1 reference

Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist

21 January 2018

1 reference

The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones.

21 January 2018

1 reference

Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly

21 January 2018

1 reference

Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.

21 January 2018

1 reference

Locus ceruleus degeneration is ubiquitous in Alzheimer's disease: possible implications for diagnosis and treatment.

21 January 2018

1 reference

Acute and chronic effects of potassium and noradrenaline on Na+, K+-ATPase activity in cultured mouse neurons and astrocytes.

21 January 2018

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beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis

21 January 2018

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Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester

21 January 2018

1 reference

Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study

21 January 2018

1 reference

daf-16 protects the nematode Caenorhabditis elegans during food deprivation.

21 January 2018

1 reference

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

21 January 2018

1 reference

The Glutamate-Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation

21 January 2018

1 reference

Energy metabolism in the brain

21 January 2018

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Neuronal-astrocytic and cytosolic-mitochondrial metabolite trafficking during brain activation, hyperammonemia and energy deprivation

21 January 2018

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Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i

21 January 2018

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Astrocytic glycogenolysis: mechanisms and functions

21 January 2018

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The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells.

21 January 2018

1 reference

First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

21 January 2018

1 reference

Abnormalities of Glucose Metabolism in Alzheimer's Disease

21 January 2018

1 reference

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis.

21 January 2018

1 reference

Cerebrospinal fluid and blood biomarkers in Alzheimer's disease

21 January 2018

1 reference

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

21 January 2018

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Glycolysis and glutamate accumulation into synaptic vesicles. Role of glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase

21 January 2018

1 reference

Microglia release ATP by exocytosis

21 January 2018

1 reference

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

21 January 2018

1 reference

Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo.

21 January 2018

1 reference

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

21 January 2018

1 reference

The effects of healthy aging, amnestic mild cognitive impairment, and Alzheimer's disease on recollection and familiarity: a meta-analytic review

21 January 2018

1 reference

Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet?

21 January 2018

1 reference

Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes

21 January 2018

1 reference

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.

21 January 2018

1 reference

Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

21 January 2018

1 reference

Glial calcium signalling in Alzheimer's disease.

21 January 2018

1 reference

Reduced glutamate neurotransmission in patients with Alzheimer's disease -- an in vivo (13)C magnetic resonance spectroscopy study.

21 January 2018

1 reference

Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets

21 January 2018

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Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons.

21 January 2018

1 reference

Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism

21 January 2018

1 reference

Noradrenergic mechanisms in neurodegenerative diseases: a theory

21 January 2018

1 reference

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.

21 January 2018

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Abeta-degrading enzymes in Alzheimer's disease.

21 January 2018

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Attenuating Aβ1-42-induced toxicity by a novel acetylcholinesterase inhibitor

21 January 2018

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Differential effects of synaptic and extrasynaptic NMDA receptors on Aβ-induced nitric oxide production in cerebrocortical neurons

21 January 2018

1 reference

Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems

21 January 2018

1 reference

The glutathione system: a new drug target in neuroimmune disorders

21 January 2018

1 reference

Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism

21 January 2018

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Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

21 January 2018

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Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD.

21 January 2018

1 reference

A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease

21 January 2018

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Neuronal and astrocytic metabolism in a transgenic rat model of Alzheimer's disease

21 January 2018

1 reference

Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance

21 January 2018

1 reference

Brain Metabolism during Fasting*

21 January 2018

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Regulation of hexokinase binding to VDAC

21 January 2018

1 reference

Effects of γ-Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ-Aminobutyric acid metabolism in the anesthetized rat In vivo

21 January 2018

1 reference

α7 Nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model.

21 January 2018

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An intact hydrophobic N-terminal sequence is critical for binding of rat brain hexokinase to mitochondria

21 January 2018

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Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease

21 January 2018

1 reference

Effects of beta-hydroxybutyrate on cognition in memory-impaired adults

21 January 2018

1 reference

Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism

21 January 2018

1 reference

13C MRS studies of neuroenergetics and neurotransmitter cycling in humans

21 January 2018

1 reference

Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study

21 January 2018

1 reference

Functional MRI and neural responses in a rat model of Alzheimer's disease.

21 January 2018

1 reference

Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type: possible role in cell loss

21 January 2018

1 reference

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA.

21 January 2018

1 reference

Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance

21 January 2018

1 reference

Broiler chickens (Ross strain) lack insulin-responsive glucose transporter GLUT4 and have GLUT8 cDNA.

21 January 2018

1 reference

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain.

21 January 2018

1 reference

Antimicrobial effects of virgin coconut oil and its medium-chain fatty acids on Clostridium difficile

21 January 2018

1 reference

The mitochondrial voltage-dependent anion channel 1 in tumor cells.

21 January 2018

1 reference

Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity

21 January 2018

1 reference

Does Alzheimer's disease begin in the brainstem?

21 January 2018

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Seizures and epileptiform activity in early Alzheimer disease: how hard should we be looking?

21 January 2018

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Noradrenaline induced stimulation of oxidative metabolism in astrocytes but not in neurons in primary cultures

21 January 2018

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Stimulation of energy metabolism by alpha-adrenergic agonists in primary cultures of astrocytes

21 January 2018

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Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro

21 January 2018

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Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II.

21 January 2018

1 reference

Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: high-resolution fast spin-echo T1-weighted imaging.

21 January 2018

1 reference

Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo.

21 January 2018

1 reference

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

21 January 2018

1 reference

Preclinical sporadic Alzheimer's disease: target for personalized diagnosis and preventive intervention

21 January 2018

1 reference

Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.

21 January 2018

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Prenatal expression of the GLUT4 glucose transporter in the mouse.

21 January 2018

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Regulated Exocytosis in Astrocytes is as Slow as the Metabolic Availability of Gliotransmitters: Focus on Glutamate and ATP.

21 January 2018

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Ketone bodies, potential therapeutic uses

21 January 2018

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Why are astrocytes important?

21 January 2018

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On the role of calcium ions in the regulation of glycogenolysis in mouse brain cortical slices.

21 January 2018

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A multicenter study of the efficacy of the ketogenic diet.

21 January 2018

1 reference

Metabolic distinction between vesicular and cytosolic GABA in cultured GABAergic neurons using 13C magnetic resonance spectroscopy

21 January 2018

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GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

21 January 2018

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Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine

21 January 2018

1 reference

Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease

21 January 2018

1 reference

Functional consequences of locus coeruleus degeneration in Alzheimer's disease

21 January 2018

1 reference

Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide

21 January 2018

1 reference

β-amyloid peptide binds and regulates ectopic ATP synthase α-chain on neural surface.

21 January 2018

1 reference

Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism

21 January 2018

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GABA and Glutamate Transporters in Brain

21 January 2018

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Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease.

21 January 2018

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The neuropathology of aminergic nuclei in Alzheimer's disease.

21 January 2018

1 reference

Amyloid precursor protein and amyloid β-peptide bind to ATP synthase and regulate its activity at the surface of neural cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.13107

1 reference

2 September 2017

1 reference

PubMed ID

25832906