The glutathione system: a new drug target in neuroimmune disorders (Q38206126)

31 August 2017

title

The glutathione system: a new drug target in neuroimmune disorders (English)

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31 August 2017

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4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24752591%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

George Anderson

2

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31 May 2020

5

Piotr Galecki

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31 May 2020

3

Olivia Dean

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31 May 2020

author name string

Gerwyn Morris

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24752591%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Marta Martin-Subero

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24752591%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Michael Maes

7

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31 May 2020

publication date

22 April 2014

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31 August 2017

number of pages

26

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inferred from page(s)

published in

Molecular Neurobiology

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31 May 2020

volume

50

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31 May 2020

issue

3

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31 May 2020

page(s)

1059-1084

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24752591%20AND%20SRC:MED&resulttype=core&format=json

Mitochondrial glutathione, a key survival antioxidant

31 May 2020

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Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus project

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Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver

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Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs?

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Studies on the mechanism of oxidative modification of human glyceraldehyde-3-phosphate dehydrogenase by glutathione: catalysis by glutaredoxin

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21 January 2018

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21 January 2018

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Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding

21 January 2018

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A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome

21 January 2018

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Increased nuclear factor-κB and loss of p53 are key mechanisms in Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS).

21 January 2018

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Inhibition of NF-kappa B by S-nitrosylation

21 January 2018

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S-nitrosylation: physiological regulation of NF-kappaB

21 January 2018

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Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses

21 January 2018

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21 January 2018

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21 January 2018

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Glutathione inhibits HIV replication by acting at late stages of the virus life cycle

21 January 2018

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Modulation of glutathione intracellular levels alters the spontaneous proliferation of lymphocyte from HTLV-1 infected patients

21 January 2018

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21 January 2018

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21 January 2018

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Redox remodeling as an immunoregulatory strategy

21 January 2018

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Extracellular redox modulation by regulatory T cells

21 January 2018

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Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase

21 January 2018

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Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens

21 January 2018

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Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells

21 January 2018

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IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension

21 January 2018

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Interleukin-2 mRNA expression, lymphokine production and DNA synthesis in glutathione-depleted T cells

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Role of nuclear glutathione as a key regulator of cell proliferation.

21 January 2018

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Role of glutathione in cell nucleus

21 January 2018

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A nuclear glutathione cycle within the cell cycle

21 January 2018

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Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.

21 January 2018

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Glutathione and apoptosis

21 January 2018

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Mitochondria, oxidants, and aging

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The impact of O2 availability on human cancer

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Mitochondrial oxidative stress: implications for cell death

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Redox-optimized ROS balance: a unifying hypothesis

21 January 2018

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Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: an experimental-computational study

21 January 2018

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Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium

21 January 2018

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Molecular diversity of glutamate receptors and implications for brain function

21 January 2018

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Oxidative stress, glutamate, and neurodegenerative disorders

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Aging, energy, and oxidative stress in neurodegenerative diseases.

21 January 2018

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Endogenous gamma-L-glutamyl and beta-L-aspartyl peptides and excitatory aminoacidergic neurotransmission in the brain

21 January 2018

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Modulation of glutamate receptor functions by glutathione

21 January 2018

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Glutathione is an endogenous ligand of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors

21 January 2018

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Glutathione and signal transduction in the mammalian CNS.

21 January 2018

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Interference of S-alkyl derivatives of glutathione with brain ionotropic glutamate receptors

21 January 2018

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Oxidized glutathione modulates N-methyl-D-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons

21 January 2018

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The ionic stoichiometry of the GLAST glutamate transporter in salamander retinal glia

21 January 2018

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Functions of glutamate transporters in the brain

21 January 2018

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Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

21 January 2018

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L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the 'collusion' hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

21 January 2018

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Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-

21 January 2018

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Redox imbalance in cystine/glutamate transporter-deficient mice

21 January 2018

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Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons

21 January 2018

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System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40.

21 January 2018

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Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation.

21 January 2018

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Quantification of hydroxyl radical produced during phacoemulsification

21 January 2018

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Nitric oxide in cell survival: a janus molecule

21 January 2018

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Kinetic analysis of intracellular concentrations of reactive nitrogen species

21 January 2018

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Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Adaptive response to oxidative stress: Bacteria, fungi, plants and animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Environmentally induced oxidative stress in aquatic animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione pathways in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Thiol regulation of endotoxin-induced release of tumour necrosis factor alpha from isolated rat Kupffer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione depletion in rats impairs T-cell and macrophage immune function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Oxidative modulation of the glutathione-redox couple enhances lipopolysaccharide-induced interleukin 12 P40 production by a mouse macrophage cell line, J774A.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione and HIV infection: reduced reduced, or increased oxidized?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione is recruited into the nucleus in early phases of cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione deficiency in patients with mitochondrial disease: implications for pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione: a redox signature in monitoring EPI-743 therapy in children with mitochondrial encephalomyopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Protein thiyl radical mediates S-glutathionylation of complex I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Apoptosis and glutathione: beyond an antioxidant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Protein-thiol oxidation and cell death: regulatory role of glutaredoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Redox regulation of the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Intracellular GSH Depletion Triggered Mitochondrial Bax Translocation to Accomplish Resveratrol-Induced Apoptosis in the U937 Cell Line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Mitochondrial Ca(2+) and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Hypoxia suppresses glutamate transport in astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Response of glial cells to ischemia: roles of reactive oxygen species and glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Preservation of extracellular glutathione by an astrocyte derived factor with properties comparable to extracellular superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Regulation of neuronal glutathione synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Inflammation, DNA methylation and colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Free radical adducts induce alterations in DNA cytosine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

An epigenetic perspective on the free radical theory of development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Functional vitamin B(12) deficiency and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

THE LACTIC ACID AND GLUTATHIONE CONTENT OF THE BLOOD OF SCHIZOPHRENIC PATIENTS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The relevance of oxidative stress status in first episode and recurrent depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Oxidative stress and glutathione response in tissue cultures from persons with major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Prefrontal cortex glutathione S-transferase levels in patients with bipolar disorder, major depression and schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutamate cysteine ligase (GCL) and self reported depression: an association study from the HUNT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Alterations in iron metabolism and the erythron in major depression: Further evidence for a chronic inflammatory process

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Erythrocyte oxidative damage in chronic fatigue syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione synthesis and turnover in the human erythrocyte: alignment of a model based on detailed enzyme kinetics with experimental data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Markers of oxidative stress in erythrocytes and plasma during aging in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Free radicals in chronic fatigue syndrome: cause or effect?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Indirect moxibustion (CV4 and CV8) ameliorates chronic fatigue: a randomized, double-blind, controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Genistein attenuates genioglossus muscle fatigue under chronic intermittent hypoxia by down-regulation of oxidative stress level and up-regulation of antioxidant enzyme activity through ERK1/2 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Venlafaxine reverses chronic fatigue-induced behavioral, biochemical and neurochemical alterations in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Epigenetic mechanisms of depression and antidepressant action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

On the potential role of glutamate transport in mental fatigue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Oxidative Stress in Parkinson`s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Advances in metal-induced oxidative stress and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Metals, toxicity and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione deficiency leads to mitochondrial damage in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione and Parkinson's disease: is this the elephant in the room?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The chemistry and biological activities of N-acetylcysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Glutathione deficiency is associated with impaired survival in HIV disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

N-acetylcysteine reverses cardiac myocyte dysfunction in HIV-Tat proteinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

N-acetylcysteine for major depressive episodes in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

N-acetylcysteine as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

A randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Folic acid, ageing, depression, and dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Emergence of adverse events following discontinuation of treatment with extended-release venlafaxine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

An open trial of methyltetrahydrofolate in elderly depressed patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Novel therapeutics for depression: L-methylfolate as a trimonoamine modulator and antidepressant-augmenting agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Functions of coenzyme Q10 in inflammation and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Aged red garlic extract reduces cigarette smoke extract-induced cell death in human bronchial smooth muscle cells by increasing intracellular glutathione levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Serum homocysteine levels and cognitive functioning in euthymic bipolar patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Oxidative stress is fundamental to hyperbaric oxygen therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Hyperbaric oxygen preconditioning attenuates hyperglycemia enhanced hemorrhagic transformation after transient MCAO in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

The effects of hyperbaric oxygen therapy on blood-brain barrier permeability in septic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Investigations on the mechanism of hyperbaric oxygen (HBO)-induced adaptive protection against oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Induction of heme oxygenase-1 and adaptive protection against the induction of DNA damage after hyperbaric oxygen treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Transcriptional Upregulation of Nrf2-Dependent Phase II Detoxification Genes in the Involved Epidermis of Vitiligo Vulgaris

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Potentials of curcumin as an antidepressant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Signal transduction events elicited by cancer prevention compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Green tea consumption is associated with depressive symptoms in the elderly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Increased CD8+ central memory T cells in patients with multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Dimethyl fumarate for treatment of multiple sclerosis: mechanism of action, effectiveness, and side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Fumaric Acid and its esters: an emerging treatment for multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Putative neuroprotective agents in neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Interleukin-2 increases intracellular glutathione levels and reverses the growth inhibiting effects of cyclophosphamide on B16 melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8705-X

Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells

21 January 2018

1 reference

12 December 2020

Control of cell cycle progression in human natural killer cells through redox regulation of expression and phosphorylation of retinoblastoma gene product protein

1 reference

12 December 2020

Glutathione regulates interleukin-2 activity on cytotoxic T-cells

1 reference

12 December 2020

Mechanism of growth promotion of mouse lymphoma L1210 cells in vitro by feeder layer or 2-mercaptoethanol

1 reference

12 December 2020

[Effect of acupuncture on serum malonaldehyde content, superoxide dismutase and glutathione peroxidase activity in chronic fatigue syndrome rats]

1 reference

12 December 2020

The effect of oral folic acid on glutathione, glycaemia and lipids in Type 2 diabetes.

1 reference

12 December 2020

Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by human alveolar macrophages

1 reference

12 December 2020

Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients

1 reference

12 December 2020

Glutathione Metabolism and Some Possible Functions of Glutathione in the Nervous System

1 reference

12 December 2020

N-acetylcysteine increases the glutathione content and protects rat alveolar type II cells against paraquat-induced cytotoxicity

1 reference

12 December 2020

Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis.

1 reference

12 December 2020

Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients

1 reference

12 December 2020

Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial.

1 reference

12 December 2020

Oral 5'-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study.

1 reference

12 December 2020

Glutathione in cerebral microvascular endothelial biology and pathobiology: implications for brain homeostasis

1 reference

12 December 2020

Intracellular glutathione redox status in human dendritic cells regulates IL-27 production and T-cell polarization

1 reference

12 December 2020

Plasma thiol status is altered in children with mitochondrial diseases

1 reference

12 December 2020

The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.

1 reference

12 December 2020

Chronic fatigue syndrome: oxidative stress and dietary modifications.

1 reference

12 December 2020

Intracellular GSH content and HIV replication in human macrophages

1 reference

12 December 2020

Preconditioning with hyperbaric oxygen induces tolerance against oxidative injury via increased expression of heme oxygenase-1 in primary cultured spinal cord neurons

1 reference

12 December 2020

N-acetylcysteine: pharmacological considerations and experimental and clinical applications.

1 reference

12 December 2020

Oxidative stress induces impairment of human erythrocyte energy metabolism through the oxygen radical-mediated direct activation of AMP-deaminase.

1 reference

12 December 2020

Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition.

1 reference

12 December 2020

Displacement of excitatory amino acid receptor ligands by acidic oligopeptides

1 reference

12 December 2020

Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells

1 reference

12 December 2020

A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: modulation by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium

1 reference

12 December 2020

Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)

1 reference

12 December 2020

The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1

1 reference

12 December 2020

Risk of autistic disorder in affected offspring of mothers with a glutathione S-transferase P1 haplotype

1 reference

12 December 2020

Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions

1 reference

12 December 2020

Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione

1 reference

12 December 2020

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome.

1 reference

12 December 2020

Thioltransferase in human red blood cells: kinetics and equilibrium

1 reference

12 December 2020

Thiol reagents and brain glutamate receptors

1 reference

12 December 2020

Glutathione prevents N -methyl-d-aspartate receptor-mediated neurotoxicity

1 reference

12 December 2020

Mitochondrial dysfunction in Parkinson's disease

1 reference

12 December 2020

Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine

1 reference

12 December 2020

Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness

1 reference

12 December 2020

Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia

1 reference

12 December 2020

Hyperbaric Oxygen Treatment Attenuates Glutathione Depletion and Improves Metabolic Restitution in Postischemic Skeletal Muscle

1 reference

12 December 2020

Folate, vitamin B12, and homocysteine in major depressive disorder.

1 reference

12 December 2020

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression.

1 reference

12 December 2020

Genetic polymorphisms of glutathione S-transferase Z1 in an Iranian population

1 reference

12 December 2020

Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells

1 reference

12 December 2020

Alterations of DNA methylation by glutathione depletion

1 reference

12 December 2020

Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice

1 reference

12 December 2020

The effects of sulfur amino acid intake on immune function in humans

1 reference

12 December 2020

Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder

1 reference

12 December 2020

Preferential response of glutathione-related enzymes to folate-dependent changes in the redox state of rat liver

1 reference

12 December 2020

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

12 December 2020

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1 reference

12 December 2020

Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression

1 reference

12 December 2020

Oxidative/nitrosative stress and immuno-inflammatory pathways in depression: treatment implications.

1 reference

12 December 2020

Role of antioxidants in chronic fatigue syndrome in mice

1 reference

12 December 2020

Effect of Hyperbaric Oxygen Treatment and Perfluorochemical Administration on Glutathione Status of the Lung

1 reference

12 December 2020

Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity.

1 reference

12 December 2020

Cell proliferation, reactive oxygen and cellular glutathione

1 reference

12 December 2020

Mechanisms for the oxidation of reduced gluthathione by stimulated granulocytes

1 reference

12 December 2020

Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling

1 reference

12 December 2020

Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase

1 reference

12 December 2020

Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiols--a high resolution ESR spin-trapping study at Q-band (35 GHz)

1 reference

12 December 2020

Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism

1 reference

12 December 2020

10.1007/S12035-014-8705-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24752591%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 May 2020

1043110700

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24752591%20AND%20SRC:MED&resulttype=core&format=json