Mass spectrometric based approaches in urine metabolomics and biomarker discovery (Q38424072)

3 September 2017

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title

Mass spectrometric based approaches in urine metabolomics and biomarker discovery (English)

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3 September 2017

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Mona M Khamis

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PubMed ID

25881008

3 September 2017

Darryl J Adamko

series ordinal

2

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PubMed ID

25881008

3 September 2017

Anas El-Aneed

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3

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3 September 2017

16 April 2015

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Mass Spectrometry Reviews

3 September 2017

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3 September 2017

36

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3 September 2017

115-134

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3 September 2017

2

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Comprehensive two-dimensional gas chromatography in metabolomics

3 September 2017

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Metabolomics in cancer biomarker discovery: current trends and future perspectives

21 January 2018

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Liquid chromatography-tandem mass spectrometry for the determination of low-molecular mass aldehydes in human urine

21 January 2018

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Metabonomics of acute kidney injury in children after cardiac surgery

21 January 2018

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Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

21 January 2018

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A case study of acute human chlorpyrifos poisoning: novel aspects on metabolism and toxicokinetics derived from liquid chromatography-tandem mass spectrometry analysis of urine samples

21 January 2018

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Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: a review

21 January 2018

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Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

21 January 2018

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The human urine metabolome

21 January 2018

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The activity of the enzymes sulphatase and beta-glucuronidase in the urine, serum and bladder tissue

21 January 2018

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Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique

21 January 2018

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Measurement of urinary concentration: a critical appraisal of methodologies.

21 January 2018

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Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations

21 January 2018

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Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal.

21 January 2018

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Measurement of intact sulfate and glucuronide phytoestrogen conjugates in human urine using isotope dilution liquid chromatography-tandem mass spectrometry with [13C(3)]isoflavone internal standards

21 January 2018

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Normalization of urinary drug concentrations with specific gravity and creatinine

21 January 2018

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Comprehensive and highly sensitive urinary steroid hormone profiling method based on stable isotope-labeling liquid chromatography-mass spectrometry

21 January 2018

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Mass spectrometry-based metabolomics

21 January 2018

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Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes

21 January 2018

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A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

21 January 2018

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Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

21 January 2018

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Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

21 January 2018

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Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures.

21 January 2018

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Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA

21 January 2018

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Metabolite profiling for plant functional genomics

21 January 2018

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Reduction of signal suppression effects in ESI-MS using a nanosplitting device

21 January 2018

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Liquid chromatography and ultra-performance liquid chromatography-mass spectrometry fingerprinting of human urine: sample stability under different handling and storage conditions for metabonomics studies.

21 January 2018

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Metabolomics-based methods for early disease diagnostics

21 January 2018

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Targeted metabolomics for biomarker discovery.

21 January 2018

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Liquid chromatography-mass spectrometric multiple reaction monitoring-based strategies for expanding targeted profiling towards quantitative metabolomics

21 January 2018

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Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome

21 January 2018

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Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS.

21 January 2018

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Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry

21 January 2018

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Fluorous derivatization combined with liquid chromatography/tandem mass spectrometry: a method for the selective and sensitive determination of sialic acids in biological samples

21 January 2018

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Effect of creatinine and specific gravity normalization techniques on xenobiotic biomarkers in smokers' spot and 24-h urines

21 January 2018

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Human metabolic phenotype diversity and its association with diet and blood pressure.

21 January 2018

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Analysis of urinary nucleosides as potential tumor markers in human breast cancer by high performance liquid chromatography/electrospray ionization tandem mass spectrometry.

21 January 2018

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Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome

21 January 2018

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Preliminary crystallographic studies of the creatinine amidohydrolase from Pseudomonas putida.

21 January 2018

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Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometry

21 January 2018

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Analysis of urinary nucleosides as helper tumor markers in hepatocellular carcinoma diagnosis.

21 January 2018

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Challenges and opportunities of metabolomics

21 January 2018

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Data processing for mass spectrometry-based metabolomics

21 January 2018

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Urine metabolomic analysis identifies potential biomarkers and pathogenic pathways in kidney cancer.

21 January 2018

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Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow

21 January 2018

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Quantitative detection of trichloroacetic acid in human urine using isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry

21 January 2018

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Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics.

21 January 2018

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Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach

21 January 2018

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Profiling of sulfoconjugates in urine by using precursor ion and neutral loss scans in tandem mass spectrometry. Application to the investigation of heavy metal toxicity in rats

21 January 2018

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Mass spectrometry strategies in metabolomics

21 January 2018

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Analytical strategies for LC-MS-based targeted metabolomics

21 January 2018

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Separation of isomers L-alanine and sarcosine in urine by electrospray ionization and tandem differential mobility analysis-mass spectrometry

21 January 2018

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The application of mass spectrometry to proteomics and metabolomics in biomarker discovery and drug development

21 January 2018

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Comparison of specific gravity and creatinine for normalizing urinary reproductive hormone concentrations

21 January 2018

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Metabolomics analysis for biomarker discovery: advances and challenges.

21 January 2018

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Heat-map visualization of gas chromatography-mass spectrometry based quantitative signatures on steroid metabolism.

21 January 2018

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Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study

21 January 2018

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Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification

21 January 2018

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Noninvasive urinary metabonomic diagnosis of human bladder cancer.

21 January 2018

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Innovation: Metabolomics: the apogee of the omics trilogy

21 January 2018

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Liquid-liquid extraction combined with differential isotope dimethylaminophenacyl labeling for improved metabolomic profiling of organic acids.

21 January 2018

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Analysis of hydrophilic metabolites in physiological fluids by HPLC-MS using a silica hydride-based stationary phase.

21 January 2018

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Comparison between external and internal standard calibration in the validation of an analytical method for 1-hydroxypyrene in human urine by high-performance liquid chromatography/tandem mass spectrometry

21 January 2018

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Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression

21 January 2018

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CE-MS for metabolomics: Developments and applications in the period 2008-2010.

21 January 2018

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21 January 2018

CE-MS in metabolomics

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CE-MS for metabolomics: developments and applications in the period 2010-2012.

21 January 2018

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Urinary markers of adrenarche: reference values in healthy subjects, aged 3-18 years

21 January 2018

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Metabolomics approach to anabolic steroid urine profiling of bovines treated with prohormones.

21 January 2018

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Exploring the human urine metabolomic potentialities by comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry

21 January 2018

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Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review

21 January 2018

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Recent and potential developments in the analysis of urine: a review.

21 January 2018

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Metabolomic biomarkers in a model of asthma exacerbation: urine nuclear magnetic resonance

21 January 2018

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Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy

21 January 2018

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Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

21 January 2018

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21 January 2018

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Quantitative analysis of 17 amino acids in the connective tissue of patients with pelvic organ prolapse using capillary electrophoresis-tandem mass spectrometry

21 January 2018

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Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry

21 January 2018

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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

21 January 2018

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Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance

21 January 2018

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Prediction of skeletal muscle and fat mass in patients with advanced cancer using a metabolomic approach

21 January 2018

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Liquid chromatography tandem mass spectrometry study of urinary nucleosides as potential cancer markers

21 January 2018

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Determination of the GABA analogue succinic semialdehyde in urine and cerebrospinal fluid by dinitrophenylhydrazine derivatization and liquid chromatography-tandem mass spectrometry: application to SSADH deficiency

21 January 2018

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Liquid chromatography-mass spectrometry based global metabolite profiling: a review.

21 January 2018

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LC-MS determination of bioactive molecules based upon stable isotope-coded derivatization method

21 January 2018

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Do not just do it, do it right: urinary metabolomics--establishing clinically relevant baselines

21 January 2018

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HILIC-MS-based shotgun metabolomic profiling of maternal urine at 9-23 weeks of gestation - establishing the baseline changes in the maternal metabolome

21 January 2018

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Deuterium Isotope Effects on Hydrophobic Interactions: The Importance of Dispersion Interactions in the Hydrophobic Phase

21 January 2018

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Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice

21 January 2018

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Urea hydrolysis and precipitation dynamics in a urine-collecting system

21 January 2018

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Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography-tandem mass spectrometry

21 January 2018

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Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers

21 January 2018

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Creatinine normalization in biological monitoring revisited: the case of 1-hydroxypyrene

21 January 2018

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Alkylation or Silylation for Analysis of Amino and Non-Amino Organic Acids by GC-MS?

21 January 2018

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Current trends and challenges in sample preparation for global metabolomics using liquid chromatography-mass spectrometry.

21 January 2018

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Deuterium isotope effects on noncovalent interactions between molecules.

21 January 2018

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Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis

21 January 2018

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Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies

21 January 2018

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Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease

21 January 2018

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Normalization strategies for metabonomic analysis of urine samples.

21 January 2018

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Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry

21 January 2018

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Acute kidney failure: a pediatric experience over 20 years

21 January 2018

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High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

21 January 2018

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HMDB 3.0--The Human Metabolome Database in 2013

21 January 2018

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Determination of peptides and proteins in human urine with capillary electrophoresis-mass spectrometry, a suitable tool for the establishment of new diagnostic markers.

21 January 2018

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Evaluation of comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry for the diagnosis of inherited metabolic disorders using an automated data processing strategy

21 January 2018

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Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers.

21 January 2018

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Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry.

21 January 2018

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Measuring fifteen endogenous estrogens simultaneously in human urine by high-performance liquid chromatography-mass spectrometry

21 January 2018

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Stable isotope dilution high-performance liquid chromatography-electrospray ionization mass spectrometry method for endogenous 2- and 4-hydroxyestrones in human urine

21 January 2018

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Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry

21 January 2018

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Comparative metabolite profiling of carboxylic acids in rat urine by CE-ESI MS/MS through positively pre-charged and (2)H-coded derivatization

21 January 2018

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Endogenous formation of dimethylamine

21 January 2018

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Modern analytical techniques in metabolomics analysis

21 January 2018

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21 January 2018

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Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine.

21 January 2018

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Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression

21 January 2018

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5-Diethylamino-naphthalene-1-sulfonyl chloride (DensCl): a novel triplex isotope labeling reagent for quantitative metabolome analysis by liquid chromatography mass spectrometry.

21 January 2018

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IsoMS: automated processing of LC-MS data generated by a chemical isotope labeling metabolomics platform

21 January 2018

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Metabolomics: Current analytical platforms and methodologies

21 January 2018

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Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks

21 January 2018

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Global metabolic profiling procedures for urine using UPLC–MS

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MAS.21455

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3 September 2017

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PubMed ID

25881008