Targeting of the Hedgehog pathway in myeloid malignancies: still a worthy chase? (Q38428941)

3 September 2017

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title

Targeting of the Hedgehog pathway in myeloid malignancies: still a worthy chase? (English)

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3 September 2017

Alesia A Khan

1

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3 September 2017

Claire N Harrison

series ordinal

2

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3 September 2017

Donal P McLornan

series ordinal

3

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3 September 2017

language of work or name

English

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publication date

19 April 2015

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British Journal of Haematology

3 September 2017

published in

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3 September 2017

volume

170

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3 September 2017

issue

3

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3 September 2017

page(s)

323-335

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PTCH1 expression at diagnosis predicts imatinib failure in chronic myeloid leukaemia patients in chronic phase.

3 September 2017

cites work

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Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation

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Indian hedgehog supports definitive erythropoiesis

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Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition

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Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.

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Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.

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Essential role of stromally induced hedgehog signaling in B-cell malignancies

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Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

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Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

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Basal cell carcinomas: attack of the hedgehog

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BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD.

21 January 2018

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Hedgehog signaling is dispensable for adult hematopoietic stem cell function

21 January 2018

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Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos

21 January 2018

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Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

21 January 2018

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

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Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target

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Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.

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Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK.

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Targeting hedgehog in hematologic malignancy.

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Hedgehog pathway activation in chronic myeloid leukemia

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New players and puzzles in the Hedgehog signaling pathway

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

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Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia

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Medicine. Disrupting Hedgehog may reverse advanced cancer, if only temporarily

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Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.

21 January 2018

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Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells

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Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms.

21 January 2018

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Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype.

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Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy

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Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients

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Hedgehog signaling in hematopoiesis

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Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

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A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

21 January 2018

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Activation of the Hedgehog pathway in chronic myelogeneous leukemia patients

21 January 2018

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The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

21 January 2018

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The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis.

21 January 2018

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Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms

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Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors.

21 January 2018

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Hedgehog signal transduction: from flies to vertebrates

21 January 2018

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Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

21 January 2018

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Mutations affecting segment number and polarity in Drosophila

21 January 2018

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Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin

21 January 2018

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Impact of ruxolitinib on the natural history of primary myelofibrosis: a comparison of the DIPSS and the COMFORT-2 cohorts.

21 January 2018

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

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Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

21 January 2018

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Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway

21 January 2018

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Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: any role for Notch, Wnt and Hh signaling pathways?

21 January 2018

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The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts

21 January 2018

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The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms.

21 January 2018

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Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation.

21 January 2018

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The Hedgehog and Wnt signalling pathways in cancer

21 January 2018

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Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration

21 January 2018

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Ruxolitinib versus standard therapy for the treatment of polycythemia vera.

21 January 2018

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Hedgehog: functions and mechanisms

21 January 2018

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

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The crosstalk of mTOR/S6K1 and Hedgehog pathways

21 January 2018

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A paracrine requirement for hedgehog signalling in cancer

21 January 2018

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

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The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

21 January 2018

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

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Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BJH.13426

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3 September 2017

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