New insights into Alzheimer's disease pathogenesis: the involvement of neuroligins in synaptic malfunction (Q38430838)

3 September 2017

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title

New insights into Alzheimer's disease pathogenesis: the involvement of neuroligins in synaptic malfunction (English)

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3 September 2017

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Ikhlas A Sindi

1

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3 September 2017

Peter R Dodd

series ordinal

2

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3 September 2017

language of work or name

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1 January 2015

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Neurodegenerative disease management

3 September 2017

published in

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3 September 2017

volume

5

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3 September 2017

issue

2

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3 September 2017

page(s)

137-145

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Cell adhesion molecules: signalling functions at the synapse

3 September 2017

cites work

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Synaptic cell adhesion molecules

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Synaptic cell adhesion

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Role for the neurexin-neuroligin complex in Alzheimer's disease

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Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression

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Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans

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Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules

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Neuroligin 2 is exclusively localized to inhibitory synapses

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A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins

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Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses

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Neurexin mediates the assembly of presynaptic terminals

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A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

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Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing

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Binding of neuroligins to PSD-95

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Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin

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A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin

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Structures, alternative splicing, and neurexin binding of multiple neuroligins

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Evolution of clams (cholinesterase-like adhesion molecules): structure and function during development

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Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons

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The structure and expression of the human neuroligin-3 gene

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Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with Neurexin-1β

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Disorder-associated mutations lead to functional inactivation of neuroligins

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A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice

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Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism

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Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations

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Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration

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Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

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Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

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Regulation of NMDA receptor trafficking by amyloid-beta

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

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Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

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Neuroligins and neurexins link synaptic function to cognitive disease

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Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampus

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Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals.

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Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior

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Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2

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Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia

21 January 2018

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Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression

21 January 2018

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A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP

21 January 2018

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21 January 2018

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The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?

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Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice

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Activity-dependent proteolytic cleavage of neuroligin-1.

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Transsynaptic signaling by activity-dependent cleavage of neuroligin-1.

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Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency

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21 January 2018

Identifiers

DOI

10.2217/NMT.14.54

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3 September 2017

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