Methyl-CpG-binding domain proteins: readers of the epigenome (Q38451083)

3 September 2017

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title

Methyl-CpG-binding domain proteins: readers of the epigenome (English)

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3 September 2017

Qian Du

1

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Clare Stirzaker

object named as

Clare Stirzaker

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3

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Susan Clark

object named as

Susan J Clark

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4

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author name string

Phuc-Loi Luu

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2

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3 September 2017

30 April 2015

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3 September 2017

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3 September 2017

7

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3 September 2017

1051-1073

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3 September 2017

6

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Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

3 September 2017

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Mining cancer methylomes: prospects and challenges

21 January 2018

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CpG islands in vertebrate genomes

21 January 2018

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Genome-wide profiling of DNA methylation in human cancer cells

21 January 2018

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Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

21 January 2018

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Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer

21 January 2018

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Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

21 January 2018

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DNA methylation and methyl-CpG binding proteins: developmental requirements and function

21 January 2018

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Molecular coupling of DNA methylation and histone methylation

21 January 2018

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A family of human zinc finger proteins that bind methylated DNA and repress transcription

21 January 2018

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ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain

21 January 2018

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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

21 January 2018

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Identification and characterization of a family of mammalian methyl-CpG binding proteins

21 January 2018

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TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

21 January 2018

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MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain

21 January 2018

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The methyl-CpG binding domain and the evolving role of DNA methylation in animals

21 January 2018

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Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

21 January 2018

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Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA

21 January 2018

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The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A

21 January 2018

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Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

21 January 2018

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Active repression of methylated genes by the chromosomal protein MBD1

21 January 2018

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Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

21 January 2018

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The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

21 January 2018

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

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Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping

21 January 2018

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MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation

21 January 2018

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The MBD protein family-reading an epigenetic mark?

21 January 2018

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Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

21 January 2018

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

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Isolation, physical mapping, and northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2.

21 January 2018

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Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

21 January 2018

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The Ski protein family is required for MeCP2-mediated transcriptional repression

21 January 2018

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Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

21 January 2018

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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

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REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.

21 January 2018

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Corepressor-dependent silencing of chromosomal regions encoding neuronal genes

21 January 2018

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Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

21 January 2018

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Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1

21 January 2018

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ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain

21 January 2018

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MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

21 January 2018

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5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging

21 January 2018

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Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases

21 January 2018

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The methyl-CpG binding protein MBD1 is required for PML-RARalpha function

21 January 2018

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Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression

21 January 2018

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Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly

21 January 2018

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Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins

21 January 2018

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MCAF mediates MBD1-dependent transcriptional repression

21 January 2018

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Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation

21 January 2018

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Differential recruitment of methyl CpG-binding domain factors and DNA methyltransferases by the orphan receptor germ cell nuclear factor initiates the repression and silencing of Oct4.

21 January 2018

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MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

21 January 2018

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MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes

21 January 2018

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The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2

21 January 2018

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21 January 2018

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p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction

21 January 2018

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Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2

21 January 2018

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Control of the DNA methylation system component MBD2 by protein arginine methylation

21 January 2018

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MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase

21 January 2018

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TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters

21 January 2018

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Methylation-dependent and -independent genomic targeting principles of the MBD protein family.

21 January 2018

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Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences

21 January 2018

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Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2.

21 January 2018

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Antithetic effects of MBD2a on gene regulation

21 January 2018

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The NuRD component Mbd3 is required for pluripotency of embryonic stem cells

21 January 2018

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MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

21 January 2018

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The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation

21 January 2018

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c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex

21 January 2018

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NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

21 January 2018

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LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

21 January 2018

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MBD3 localizes at promoters, gene bodies and enhancers of active genes

21 January 2018

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NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment

21 January 2018

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Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells

21 January 2018

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The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes

21 January 2018

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The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes

21 January 2018

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MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

21 January 2018

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MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress

21 January 2018

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Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA.

21 January 2018

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DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

21 January 2018

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

21 January 2018

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Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation

21 January 2018

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Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized

21 January 2018

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Down-regulation of MeCP2 in Hirschsprung's disease

21 January 2018

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Identification of MeCP2 mutations in a series of females with autistic disorder

21 January 2018

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Methyl-CpG-binding protein 2 polymorphisms and vulnerability to autism

21 January 2018

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Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation

21 January 2018

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MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism.

21 January 2018

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Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome

21 January 2018

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MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status

21 January 2018

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Novel variants identified in methyl-CpG-binding domain genes in autistic individuals

21 January 2018

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MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers.

21 January 2018

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Methyl-CpG binding domain 1 gene polymorphisms and risk of primary lung cancer.

21 January 2018

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Interaction-based discovery of functionally important genes in cancers

21 January 2018

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Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2

21 January 2018

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Reduced mRNA expression levels of MBD2 and MBD3 in gastric carcinogenesis

21 January 2018

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MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland

21 January 2018

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A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility.

21 January 2018

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Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status

21 January 2018

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Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1

21 January 2018

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Associations between aberrant DNA methylation and transcript levels of DNMT1 and MBD2 in CD4+T cells from patients with systemic lupus erythematosus

21 January 2018

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Decreased expression of MBD2 and MBD4 gene and genomic-wide hypomethylation in patients with primary immune thrombocytopenia

21 January 2018

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Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

21 January 2018

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Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency.

21 January 2018

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The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

21 January 2018

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Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability

21 January 2018

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The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1.

21 January 2018

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De novo mutations in moderate or severe intellectual disability

21 January 2018

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Reciprocal deletion and duplication at 2q23.1 indicates a role for MBD5 in autism spectrum disorder.

21 January 2018

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Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains

21 January 2018

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Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function

21 January 2018

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Comparative study of methyl-CpG-binding domain proteins

21 January 2018

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p66 -MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex

21 January 2018

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Direct homo- and hetero-interactions of MeCP2 and MBD2.

21 January 2018

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MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

21 January 2018

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21 January 2018

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The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2

21 January 2018

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Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain

21 January 2018

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The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

21 January 2018

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Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation

21 January 2018

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The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA

21 January 2018

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Structure and function of the nucleosome-binding PWWP domain

21 January 2018

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MBD6 is a direct target of Oct4 and controls the stemness and differentiation of adipose tissue-derived stem cells

21 January 2018

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CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation

21 January 2018

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SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

21 January 2018

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A novel family of bromodomain genes

21 January 2018

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The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin

21 January 2018

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NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines

21 January 2018

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Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation

21 January 2018

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Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA

21 January 2018

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The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties

21 January 2018

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Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

21 January 2018

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Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

21 January 2018

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Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.

21 January 2018

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Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

21 January 2018

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Genome-wide binding of MBD2 reveals strong preference for highly methylated loci

21 January 2018

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Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

21 January 2018

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Intergenic transcripts regulate the epigenetic state of rRNA genes

21 January 2018

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Components of the DNA methylation system of chromatin control are RNA-binding proteins

21 January 2018

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Heterochromatin revisited

21 January 2018

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Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation

21 January 2018

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Targeted manipulation of heterochromatin rescues MeCP2 Rett mutants and re-establishes higher order chromatin organization.

21 January 2018

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Linking DNA methylation and histone modification: patterns and paradigms

21 January 2018

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Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation.

21 January 2018

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The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation

21 January 2018

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MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.

21 January 2018

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Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3

21 January 2018

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Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs.

21 January 2018

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Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

21 January 2018

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PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

21 January 2018

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Histone arginine methylation

21 January 2018

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Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor

21 January 2018

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Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

21 January 2018

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Nucleosome remodeling and epigenetics.

21 January 2018

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Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.

21 January 2018

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Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells.

21 January 2018

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Three-dimensional genome architecture: players and mechanisms

21 January 2018

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Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation

21 January 2018

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Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

21 January 2018

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Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain

21 January 2018

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Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

21 January 2018

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DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

21 January 2018

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Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin

21 January 2018

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Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells

21 January 2018

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Deterministic direct reprogramming of somatic cells to pluripotency

21 January 2018

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No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos

21 January 2018

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The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming

21 January 2018

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CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2

21 January 2018

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Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells

21 January 2018

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A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer

21 January 2018

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Deficiency of Mbd2 suppresses intestinal tumorigenesis

21 January 2018

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Disruption of MBD5 contributes to a spectrum of psychopathology and neurodevelopmental abnormalities

21 January 2018

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Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder

21 January 2018

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Haploinsufficiency of MBD5 associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures

21 January 2018

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

21 January 2018

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Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

21 January 2018

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An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex

21 January 2018

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Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.

21 January 2018

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Unusual characteristics of the DNA binding domain of epigenetic regulatory protein MeCP2 determine its binding specificity

21 January 2018

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Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.15.39

1 reference

3 September 2017

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PubMed ID

25927341