Opportunities and challenges provided by crosstalk between signalling pathways in cancer (Q38485894)

3 September 2017

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title

Opportunities and challenges provided by crosstalk between signalling pathways in cancer (English)

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3 September 2017

2

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3 September 2017

A Prahallad

1

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3 September 2017

language of work or name

English

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publication date

18 May 2015

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3 September 2017

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3 September 2017

volume

35

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3 September 2017

issue

9

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3 September 2017

page(s)

1073-1079

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

3 September 2017

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Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

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RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells

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Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models

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Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

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Strategies for optimizing combinations of molecularly targeted anticancer agents

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Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements

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Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity

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Improving outcomes in patients with advanced renal cell carcinoma

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A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer

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Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer

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In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

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RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

21 January 2018

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

21 January 2018

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.151

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.151

Combined BRAF (Dabrafenib) and MEK inhibition (Trametinib) in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.151

Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.151

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.151

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia

21 January 2018

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Hepatotoxicity with combination of vemurafenib and ipilimumab

21 January 2018

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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

21 January 2018

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.151

TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.151

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.151

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.151

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

21 January 2018

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31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25982281

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2015.151

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Dimensions Publication ID

3 September 2017

1021485255

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