Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia (Q24299821)

B-Raf proto-oncogene, serine/threonine kinase

1 reference

identical protein binding

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Braf transforming gene

1 reference

V-raf-leukemia viral oncogene 1

1 reference

1 reference

Caroline Springer

11

Caroline

Springer

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19 October 2023

Richard Marais

12

Richard

Marais

1 reference

19 October 2023

Brian J Druker

10

Brian J

Druker

1 reference

19 October 2023

Leisl M Packer

1

Leisl M

Packer

1 reference

19 October 2023

Sareena Rana

2

Sareena

Rana

1 reference

19 October 2023

Robert Hayward

3

Robert

Hayward

1 reference

19 October 2023

Thomas O'Hare

4

Thomas

O'Hare

1 reference

19 October 2023

Christopher A Eide

5

Christopher A

Eide

1 reference

19 October 2023

Ana Rebocho

6

Ana

Rebocho

1 reference

19 October 2023

Sonja Heidorn

7

Sonja

Heidorn

1 reference

19 October 2023

Matthew S Zabriskie

8

Matthew S

Zabriskie

1 reference

19 October 2023

Ion Niculescu-Duvaz

9

Ion

PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells

Niculescu-Duvaz

1 reference

19 October 2023

language of work or name

English

0 references

publication date

13 December 2011

0 references

published in

Cancer Cell

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volume

20

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page(s)

715-27

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issue

6

0 references

cites work

1 reference

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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

19 March 2017

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

19 March 2017

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RIP2 is a Raf1-activated mitogen-activated protein kinase kinase

19 March 2017

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19 March 2017

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19 March 2017

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

7 April 2017

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The RAF proteins take centre stage

7 April 2017

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The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile

7 April 2017

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27 September 2017

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Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia

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BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4.

27 September 2017

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Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia

27 September 2017

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27 September 2017

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Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

27 September 2017

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27 September 2017

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Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells

27 September 2017

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27 September 2017

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29 November 2018

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The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation

29 November 2018

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29 November 2018

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29 November 2018

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29 November 2018

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29 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22169110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CCR.2011.11.004

inferred from DOI database lookup

7 January 2021

based on heuristic

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CCR.2011.11.004

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2011.11.004

1 reference

release_ip3z6zytzbdvtco4fazrjrfunu

832003

Fatcat ID

0 references

832003

1 reference

1 reference

1 reference