Brain Food for Alzheimer-Free Ageing: Focus on Herbal Medicines (Q38532717)

3 September 2017

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title

Brain Food for Alzheimer-Free Ageing: Focus on Herbal Medicines (English)

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3 September 2017

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Helmut M Hügel

1

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PubMed ID

26092628

3 September 2017

language of work or name

English

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publication date

1 January 2015

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Advances in Experimental Medicine and Biology

3 September 2017

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3 September 2017

863

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3 September 2017

95-116

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Natural compounds against Alzheimer's disease: molecular recognition of Aβ1-42 peptide by Salvia sclareoides extract and its major component, rosmarinic acid, as investigated by NMR.

3 September 2017

1 reference

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Protective effect of fermented red ginseng on a transient focal ischemic rats

31 March 2020

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FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease

31 March 2020

1 reference

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Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models: An experimental study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro

31 March 2020

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Chinese medicine injection qingkailing for treatment of acute ischemia stroke: a systematic review of randomized controlled trials

31 March 2020

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Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptide and protects pancreatic beta-cells against cytotoxicity

31 March 2020

1 reference

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Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.

31 March 2020

1 reference

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In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia

31 March 2020

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Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses

31 March 2020

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Curcumin--from molecule to biological function.

31 March 2020

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Novel squamosamide derivative (compound FLZ) attenuates Abeta25-35-induced toxicity in SH-SY5Y cells

31 March 2020

1 reference

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FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging.

31 March 2020

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Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.

31 March 2020

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Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models

31 March 2020

1 reference

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Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Diet and cognition: interplay between cell metabolism and neuronal plasticity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Common tea formulations modulate in vitro digestive recovery of green tea catechins.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Therapeutic roles of curcumin: lessons learned from clinical trials

31 March 2020

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Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies

31 March 2020

1 reference

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REVIEW: Curcumin and Alzheimer's Disease

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe).

31 March 2020

1 reference

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Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test

31 March 2020

1 reference

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An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease.

31 March 2020

1 reference

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Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia

31 March 2020

1 reference

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Protection of SH-SY5Y neuronal cells from glutamate-induced apoptosis by 3,6'-disinapoyl sucrose, a bioactive compound isolated from Radix Polygala

31 March 2020

1 reference

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JD-30, an active fraction extracted from Danggui-Shaoyao-San, decreases β-amyloid content and deposition, improves LTP reduction and prevents spatial cognition impairment in SAMP8 mice.

31 March 2020

1 reference

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Bioactive peptides/chitosan nanoparticles enhance cellular antioxidant activity of (-)-epigallocatechin-3-gallate.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

L-3-n-butylphthalide protects against vascular dementia via activation of the Akt kinase pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Protective effects of Angelica sinensis extract on amyloid beta-peptide-induced neurotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Ginsenoside Rg1 attenuates oligomeric Aβ(1-42)-induced mitochondrial dysfunction

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Effects of Panax notoginseng saponin on α, β, and γ secretase involved in Aβ deposition in SAMP8 mice.

31 March 2020

1 reference

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Redox chemistry of green tea polyphenols: therapeutic benefits in neurodegenerative diseases

31 March 2020

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Danshen diversity defeating dementia

31 March 2020

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Chinese herbs for dementia diseases

31 March 2020

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Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies.

31 March 2020

1 reference

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A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients.

31 March 2020

1 reference

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The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease

31 March 2020

1 reference

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Proof of concept studies to confirm the delivery of curcumin loaded solid lipid nanoparticles (C-SLNs) to brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

A natural squamosamide derivative FLZ inhibits homocysteine-induced rat brain microvascular endothelial cells dysfunction

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3.

31 March 2020

1 reference

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Glycyrrhiza and Uncaria Hook contribute to protective effect of traditional Japanese medicine yokukansan against amyloid β oligomer-induced neuronal death

31 March 2020

1 reference

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Identification of BACE1 inhibitors from Panax ginseng saponins-An Insilco approach

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer's disease experimental models

31 March 2020

1 reference

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Where is the hope for drug discovery? Let history tell the future.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

FLZ, a novel HSP27 and HSP70 inducer, protects SH-SY5Y cells from apoptosis caused by MPP(+).

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Mechanistic insights of curcumin interactions with the core-recognition motif of β-amyloid peptide.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Influence of ginsenoside Rb1 on brain neurosteroid during acute immobilization stress.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

(-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway

31 March 2020

1 reference

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Therapeutic applications of compounds in the Magnolia family

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Inhibitory effect of ethanol extract of Magnolia officinalis on memory impairment and amyloidogenesis in a transgenic mouse model of Alzheimer's disease via regulating β-secretase activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Effect of conjugated linoleic acid, μ-calpain inhibitor, on pathogenesis of Alzheimer's disease

31 March 2020

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https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Overview of metabolism and bioavailability enhancement of polyphenols.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice

31 March 2020

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Preservation of (-)-epigallocatechin-3-gallate antioxidant properties loaded in heat treated β-lactoglobulin nanoparticles

31 March 2020

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Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Protective Effect against Hydroxyl-induced DNA Damage and Antioxidant Activity of Radix Glycyrrhizae (Liquorice Root).

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Catalpol protects primary cultured cortical neurons induced by Abeta(1-42) through a mitochondrial-dependent caspase pathway.

31 March 2020

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Study of antiepileptic effect of extracts from Acorus tatarinowii Schott

31 March 2020

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Traditional chinese medicine for senile dementia

31 March 2020

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Analysis and detection of the chemical constituents of Radix Polygalae and their metabolites in rats after oral administration by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass

31 March 2020

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Modified Wendan Decoction can Attenuate Neurotoxic Action Associated with Alzheimer's Disease

31 March 2020

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In vitro screening on amyloid precursor protein modulation of plants used in Ayurvedic and traditional Chinese medicine for memory improvement.

31 March 2020

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Jujuboside A, a neuroprotective agent from semen Ziziphi Spinosae ameliorates behavioral disorders of the dementia mouse model induced by Aβ 1-42.

31 March 2020

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Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?

31 March 2020

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Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro.

31 March 2020

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Systematic review on the efficacy and safety of herbal medicines for vascular dementia

31 March 2020

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Plasma phospholipids identify antecedent memory impairment in older adults.

31 March 2020

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Chinese herbal medicine for Mild Cognitive Impairment and Age Associated Memory Impairment: a review of randomised controlled trials

31 March 2020

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Evaluating the traditional Chinese literature for herbal formulae and individual herbs used for age-related dementia and memory impairment.

31 March 2020

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Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

31 March 2020

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Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial.

31 March 2020

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Multifunctional nanoliposomes with curcumin-lipid derivative and brain targeting functionality with potential applications for Alzheimer disease.

31 March 2020

1 reference

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Simple structure-based approach for predicting the activity of inhibitors of beta-secretase (BACE1) associated with Alzheimer's disease

31 March 2020

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Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils

31 March 2020

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Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophages

31 March 2020

1 reference

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l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells

31 March 2020

1 reference

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L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice

31 March 2020

1 reference

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Potassium 2-(1-hydroxypentyl)-benzoate improves memory deficits and attenuates amyloid and τ pathologies in a mouse model of Alzheimer's disease

31 March 2020

1 reference

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Short-term study on the effects of rosemary on cognitive function in an elderly population.

31 March 2020

1 reference

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Anti-proliferative effects of the novel squamosamide derivative (FLZ) on HepG2 human hepatoma cells by regulating the cell cycle-related proteins are associated with decreased Ca(2+)/ROS levels

31 March 2020

1 reference

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Ginsenoside Rg1 decreases Aβ(1-42) level by upregulating PPARγ and IDE expression in the hippocampus of a rat model of Alzheimer's disease

31 March 2020

1 reference

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Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations

31 March 2020

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Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies

31 March 2020

1 reference

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Estrogenic effect of ginsenoside Rg1 on APP processing in post-menopausal platelets

31 March 2020

1 reference

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Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia.

31 March 2020

1 reference

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Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms.

31 March 2020

1 reference

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Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease.

31 March 2020

1 reference

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Hoelen (Poria Cocos Wolf) and ginseng (Panax Ginseng C. A. Meyer), the ingredients of a Chinese prescription DX-9386, individually promote hippocampal long-term potentiation in vivo.

31 March 2020

1 reference

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Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models

31 March 2020

1 reference

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Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway

31 March 2020

1 reference

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Metabolic fate of polyphenols in the human superorganism

31 March 2020

1 reference

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The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

31 March 2020

1 reference

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Thermodynamic analysis of the molecular interactions between amyloid beta-peptide 42 and (-)-epigallocatechin-3-gallate

31 March 2020

1 reference

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Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice

31 March 2020

1 reference

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Tanshinones inhibit amyloid aggregation by amyloid-β peptide, disaggregate amyloid fibrils, and protect cultured cells

31 March 2020

1 reference

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Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

31 March 2020

1 reference

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The worldwide economic impact of dementia 2010.

31 March 2020

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Caloric restriction improves memory in elderly humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Protonation of epigallocatechin-3-gallate (EGCG) results in massive aggregation and reduced oral bioavailability of EGCG-dispersed selenium nanoparticles

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Bioassay-Guided Isolation of Neuroprotective Compounds from Uncaria rhynchophylla against Beta-Amyloid-Induced Neurotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Huperzine A for mild cognitive impairment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Pharmacokinetics of phenolic compounds of Danshen extract in rat blood and brain by microdialysis sampling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

HPLC method with fluorescence detection for the determination of ligustilide in rat plasma and its pharmacokinetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β(₁₋₄₂)-injected rats and may be connected to synaptic changes in the hippocampus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

Kai-xin-san, a chinese herbal decoction containing ginseng radix et rhizoma, polygalae radix, acori tatarinowii rhizoma, and poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-18365-7_5

10.1007/978-3-319-18365-7_5

31 March 2020

Identifiers

DOI

1 reference

3 September 2017

1 reference

PubMed ID

26092628