The detection and characterization of pleiotropy: discovery, progress, and promise (Q38557046)

4 September 2017

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title

The detection and characterization of pleiotropy: discovery, progress, and promise (English)

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4 September 2017

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2

Dana C Crawford

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4 September 2017

3

Sarah A Pendergrass

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4 September 2017

Anna L Tyler

1

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4 September 2017

language of work or name

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28 July 2015

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Briefings in Bioinformatics

4 September 2017

published in

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4 September 2017

volume

17

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4 September 2017

issue

1

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4 September 2017

page(s)

13-22

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One hundred years of pleiotropy: a retrospective

4 September 2017

cites work

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Phenomics: the next challenge

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Pleiotropy in complex traits: challenges and strategies

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A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts.

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Shadows of complexity: what biological networks reveal about epistasis and pleiotropy

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Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene.

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Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes

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The nature and extent of mutational pleiotropy in gene expression of male Drosophila serrata.

21 January 2018

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Genome-wide association mapping of natural variation in odour-guided behaviour in Drosophila.

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Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss.

21 January 2018

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Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy?

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Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals

21 January 2018

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Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

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Abundant pleiotropy in human complex diseases and traits.

21 January 2018

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Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster

21 January 2018

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Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene

21 January 2018

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Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3

21 January 2018

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Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics

21 January 2018

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PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations

21 January 2018

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The apolipoprotein E E4 allele and sex-specific risk of Alzheimer's disease.

21 January 2018

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Detecting shared pathogenesis from the shared genetics of immune-related diseases

21 January 2018

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Identifying disease associations via genome-wide association studies

21 January 2018

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New IBD genetics: common pathways with other diseases.

21 January 2018

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

21 January 2018

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PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies

21 January 2018

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Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies

21 January 2018

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A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects

21 January 2018

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Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

21 January 2018

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Phenome-wide association studies (PheWASs) for functional variants

21 January 2018

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Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk

21 January 2018

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Can genetic pleiotropy replicate common clinical constellations of cardiovascular disease and risk?

21 January 2018

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Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis

21 January 2018

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A PheWAS approach in studying HLA-DRB1*1501.

21 January 2018

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Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls

21 January 2018

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Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network

21 January 2018

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Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study

21 January 2018

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Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studies

21 January 2018

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Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery

21 January 2018

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The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery

21 January 2018

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The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study

21 January 2018

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Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study

21 January 2018

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Pleiotropic genes for metabolic syndrome and inflammation

21 January 2018

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Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia

21 January 2018

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Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia

21 January 2018

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Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia

21 January 2018

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Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium

21 January 2018

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Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities

21 January 2018

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Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study

21 January 2018

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Rare-variant association testing for sequencing data with the sequence kernel association test

21 January 2018

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Clinical assessment incorporating a personal genome

21 January 2018

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Validation of PhenX measures in the personalized medicine research project for use in gene/environment studies

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIB%2FBBV050

PhenX: a toolkit for interdisciplinary genetics research

21 January 2018

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PhenX RISING: real world implementation and sharing of PhenX measures

21 January 2018

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eMERGEing progress in genomics-the first seven years

21 January 2018

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Data compatibility in the addiction sciences: an examination of measure commonality

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIB%2FBBV050

Using PhenX measures to identify opportunities for cross-study analysis

21 January 2018

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The human disease network

21 January 2018

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Exploring the human diseasome: the human disease network

21 January 2018

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Genome-wide epistasis and pleiotropy characterized by the bipartite human phenotype network

21 January 2018

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The multiscale backbone of the human phenotype network based on biological pathways

21 January 2018

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A general framework for association tests with multivariate traits in large-scale genomics studies

21 January 2018

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Canonical correlation analysis for gene-based pleiotropy discovery

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIB%2FBBV050

Estimating and testing pleiotropy of single genetic variant for two quantitative traits.

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIB%2FBBV050

Use of pleiotropy to model genetic interactions in a population

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIB%2FBBV050

CAPE: an R package for combined analysis of pleiotropy and epistasis

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIB%2FBBV050

A genetic interaction network model of a complex neurological disease

21 January 2018

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Putting pleiotropy and selection into context defines a new paradigm for interpreting genetic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIB%2FBBV050

Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus

21 January 2018

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A multivariate test of association

21 January 2018

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Phenotypic diversity, allelic series and modifier genes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/BIB/BBV050

1 reference

4 September 2017

DBLP publication ID

journals/bib/TylerCP16

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DBLP Dataset 2021-01-02

28 January 2021

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