Regulatory T cells: tolerance induction in solid organ transplantation (Q38557841)

4 September 2017

title

Regulatory T cells: tolerance induction in solid organ transplantation (English)

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4 September 2017

main subject

organ transplantation

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Dominic Boardman

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

T Vaikunthanathan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

R I Lechler

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

G Lombardi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

19 April 2017

1 reference

Clinical and Experimental Immunology

4 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

189

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

197-210

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28422316%20AND%20SRC:MED&resulttype=core&format=json

Long-term management of immunosuppression after pediatric liver transplantation: is minimization or withdrawal desirable or possible or both?

6 June 2020

cites work

1 reference

Chronic renal failure after transplantation of a nonrenal organ

21 January 2018

1 reference

Posttransplantation hypertension related to calcineurin inhibitors

21 January 2018

1 reference

Complications of Immunosuppressive Therapy in Solid Organ Transplantation

21 January 2018

1 reference

Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients.

21 January 2018

1 reference

Clinical operational tolerance in liver transplantation: state-of-the-art perspective and future prospects

21 January 2018

1 reference

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

21 January 2018

1 reference

Hot-topic debate on tolerance: immunosuppression withdrawal

21 January 2018

1 reference

Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease.

21 January 2018

1 reference

Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes

21 January 2018

1 reference

Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes

21 January 2018

1 reference

Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates.

21 January 2018

1 reference

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

21 January 2018

1 reference

Role of regulatory T cells and FOXP3 in human diseases.

21 January 2018

1 reference

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation

21 January 2018

1 reference

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells

21 January 2018

1 reference

FOXP3: not just for regulatory T cells anymore

21 January 2018

1 reference

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

1 reference

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

21 January 2018

1 reference

In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells

21 January 2018

1 reference

Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model.

21 January 2018

1 reference

Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor

21 January 2018

1 reference

Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO.

21 January 2018

1 reference

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner.

21 January 2018

1 reference

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

21 January 2018

1 reference

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

21 January 2018

1 reference

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

21 January 2018

1 reference

A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells

21 January 2018

1 reference

Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells

21 January 2018

1 reference

DNA methylation controls Foxp3 gene expression

21 January 2018

1 reference

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

21 January 2018

1 reference

Thymic versus induced regulatory T cells - who regulates the regulators?

21 January 2018

1 reference

Methods for discovery and characterization of cell subsets in high dimensional mass cytometry data

21 January 2018

1 reference

Beyond the age of cellular discovery.

21 January 2018

1 reference

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

21 January 2018

1 reference

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

21 January 2018

1 reference

Exosome secretion: molecular mechanisms and roles in immune responses

21 January 2018

1 reference

CD73 expression on extracellular vesicles derived from CD4+ CD25+ Foxp3+ T cells contributes to their regulatory function

21 January 2018

1 reference

MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells

21 January 2018

1 reference

Human T regulatory cell therapy: take a billion or so and call me in the morning

21 January 2018

1 reference

In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures

21 January 2018

1 reference

Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

21 January 2018

1 reference

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

21 January 2018

1 reference

How can the latest technologies advance cell therapy manufacturing?

21 January 2018

1 reference

Expansion of human regulatory T-cells from patients with type 1 diabetes

21 January 2018

1 reference

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

21 January 2018

1 reference

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

21 January 2018

1 reference

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells

21 January 2018

1 reference

Regulatory T-cell therapy for transplantation: how many cells do we need?

21 January 2018

1 reference

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.

21 January 2018

1 reference

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

21 January 2018

1 reference

Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

21 January 2018

1 reference

Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation.

21 January 2018

1 reference

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

21 January 2018

1 reference

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations

21 January 2018

1 reference

Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

21 January 2018

1 reference

Plasticity of CD4(+) FoxP3(+) T cells

21 January 2018

1 reference

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

21 January 2018

1 reference

Regulatory T cell plasticity: beyond the controversies.

21 January 2018

1 reference

Identification of IL-17-producing FOXP3+ regulatory T cells in humans.

21 January 2018

1 reference

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines.

21 January 2018

1 reference

Phenotypical and functional specialization of FOXP3+ regulatory T cells

21 January 2018

1 reference

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

21 January 2018

1 reference

Epigenetic control of the foxp3 locus in regulatory T cells

21 January 2018

1 reference

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting.

21 January 2018

1 reference

Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells

21 January 2018

1 reference

Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function

21 January 2018

1 reference

Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.

21 January 2018

1 reference

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

21 January 2018

1 reference

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

21 January 2018

1 reference

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

21 January 2018

1 reference

Indefinite mouse heart allograft survival in recipient treated with CD4(+)CD25(+) regulatory T cells with indirect allospecificity and short term immunosuppression.

21 January 2018

1 reference

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice.

21 January 2018

1 reference

Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

21 January 2018

1 reference

Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells

21 January 2018

1 reference

Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy

21 January 2018

1 reference

Donor-specific regulatory T cells generated on donor B cells are superior to CD4+CD25high cells in controlling alloimmune responses in humanized mice

21 January 2018

1 reference

What Is Direct Allorecognition?

21 January 2018

1 reference

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

21 January 2018

1 reference

Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens

21 January 2018

1 reference

Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg

21 January 2018

1 reference

Gene therapy of arthritis with TCR isolated from the inflamed paw.

21 January 2018

1 reference

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

21 January 2018

1 reference

Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

21 January 2018

1 reference

Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells

21 January 2018

1 reference

Antigen-specificity using chimeric antigen receptors: the future of regulatory T-cell therapy?

21 January 2018

1 reference

The promise and potential pitfalls of chimeric antigen receptors

21 January 2018

1 reference

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

21 January 2018

1 reference

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

21 January 2018

1 reference

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

21 January 2018

1 reference

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

21 January 2018

1 reference

CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

21 January 2018

1 reference

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

21 January 2018

1 reference

Chimeric antigen receptor T cells for sustained remissions in leukemia

21 January 2018

1 reference

Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia

21 January 2018

1 reference

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

21 January 2018

1 reference

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

21 January 2018

1 reference

CARs on track in the clinic

21 January 2018

1 reference

Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice

21 January 2018

1 reference

Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor.

21 January 2018

1 reference

Suppression of murine colitis and its associated cancer by carcinoembryonic antigen-specific regulatory T cells

21 January 2018

1 reference

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery.

21 January 2018

1 reference

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

21 January 2018

1 reference

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

21 January 2018

1 reference

Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor.

21 January 2018

1 reference

Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation

21 January 2018

1 reference

A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation.

21 January 2018

1 reference

Functional Modulation of Regulatory T Cells by IL-2.

21 January 2018

1 reference

Interleukin-2 and regulatory T cells in graft-versus-host disease

21 January 2018

1 reference

Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

21 January 2018

1 reference

Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients

21 January 2018

1 reference

The role of interleukin-2 during homeostasis and activation of the immune system

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5508315

Exosomes: composition, biogenesis and function

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5508315

Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5508315

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5508315

Peripheral CD4+ CD25+ Treg cell expansion in lung transplant recipients is not affected by calcineurin inhibitors

4 November 2018

1 reference

In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance

21 January 2018

1 reference

12 December 2020

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

1 reference

12 December 2020

Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)

1 reference

12 December 2020

Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up

1 reference

12 December 2020

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

1 reference

12 December 2020

Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: Potential reagents to promote donor-specific transplantation tolerance

1 reference

12 December 2020

Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation

1 reference

12 December 2020

The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality

1 reference

12 December 2020

Direct expansion of human allospecific FoxP3+CD4+ regulatory T cells with allogeneic B cells for therapeutic application

1 reference

12 December 2020

Immunology. Regulatory T cells get their chance to shine

1 reference

12 December 2020

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells

1 reference

12 December 2020

Isolation of CD4+CD25+ regulatory T cells for clinical trials

1 reference

12 December 2020

Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

1 reference

12 December 2020

Tolerance profiles and immunosuppression

1 reference

12 December 2020

Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells

1 reference

12 December 2020

Cancers complicating organ transplantation

1 reference

12 December 2020

Analyses of Peripheral Blood Mononuclear Cells in Operational Tolerance After Pediatric Living Donor Liver Transplantation

1 reference

12 December 2020