The role of interleukin-2 during homeostasis and activation of the immune system (Q34255232)

31 July 2017

The role of interleukin-2 during homeostasis and activation of the immune system (English)

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31 July 2017

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1

Onur Boyman

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31 July 2017

2

Jonathan Sprent

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31 July 2017

17 February 2012

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Nature Reviews Immunology

31 July 2017

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31 July 2017

12

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31 July 2017

3

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31 July 2017

180-190

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Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

31 July 2017

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Interleukin-2: inception, impact, and implications

31 March 2020

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The biology of interleukin-2.

31 March 2020

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

31 March 2020

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Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

31 March 2020

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Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis

31 March 2020

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Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival

31 March 2020

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Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses

31 March 2020

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Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties

31 March 2020

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A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

31 March 2020

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

31 March 2020

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Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

31 March 2020

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The IL-2/IL-2 receptor system: a current overview

31 March 2020

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Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

31 March 2020

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Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors

31 March 2020

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The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

31 March 2020

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Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis

31 March 2020

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Immune responses in interleukin-2-deficient mice

31 March 2020

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IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion

31 March 2020

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CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses

31 March 2020

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Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

31 March 2020

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Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections.

31 March 2020

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Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells

31 March 2020

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Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

31 March 2020

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Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells

31 March 2020

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mTOR regulates memory CD8 T-cell differentiation

31 March 2020

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Homeostatic proliferation and survival of naïve and memory T cells

31 March 2020

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B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation

31 March 2020

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Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses

31 March 2020

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CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

31 March 2020

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CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

31 March 2020

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CTLA-4 control over Foxp3+ regulatory T cell function

31 March 2020

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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

31 March 2020

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An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2

31 March 2020

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T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis

31 March 2020

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Interleukin-2 receptor signaling: at the interface between tolerance and immunity

31 March 2020

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A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells

31 March 2020

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

31 March 2020

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Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells

31 March 2020

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Stability of the regulatory T cell lineage in vivo.

31 March 2020

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Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice

31 March 2020

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IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo

31 March 2020

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

31 March 2020

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IL-2- and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets

31 March 2020

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A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasis

31 March 2020

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Th17 and regulatory T cells in mediating and restraining inflammation

31 March 2020

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Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

31 March 2020

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Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

31 March 2020

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CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model

31 March 2020

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Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.

31 March 2020

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Differentiation of effector CD4 T cell populations (*)

31 March 2020

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Interleukin 2 plays a central role in Th2 differentiation.

31 March 2020

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Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression

31 March 2020

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Follicular helper CD4 T cells (TFH)

31 March 2020

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

31 March 2020

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ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6

31 March 2020

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Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

31 March 2020

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The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

31 March 2020

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The distinct surface of human blood dendritic cells, as observed after an improved isolation method

31 March 2020

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Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function?

31 March 2020

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CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition

31 March 2020

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Early IL-2 Production by Mouse Dendritic Cells Is the Result of Microbial-Induced Priming

31 March 2020

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Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice

31 March 2020

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Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan

31 March 2020

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A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy

31 March 2020

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Enhanced T-cell activation and T-cell-dependent IL-2 production by CD83+, CD25high, CD43high human monocyte-derived dendritic cells

31 March 2020

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Anti-CD25 antibodies affect cytokine synthesis pattern of human dendritic cells and decrease their ability to prime allogeneic CD4+ T cells.

31 March 2020

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Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation

31 March 2020

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CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis

31 March 2020

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Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2.

31 March 2020

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The IL-2 receptor present on human embryonic fibroblasts is functional in the absence of P64/IL-2R gamma chain.

31 March 2020

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Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

31 March 2020

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Interleukin-2 directly increases albumin permeability of bovine and human vascular endothelium in vitro

31 March 2020

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Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome

31 March 2020

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Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity

31 March 2020

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The soluble interleukin-2 receptor: biology, function, and clinical application

31 March 2020

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T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies

31 March 2020

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Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

31 March 2020

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Soluble IL-2Rα facilitates IL-2-mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma

31 March 2020

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Progress in human tumour immunology and immunotherapy

31 March 2020

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Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines

31 March 2020

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High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.

31 March 2020

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Interleukin-2 therapy in patients with HIV infection

31 March 2020

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Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease

31 March 2020

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Application of IL-2 and other cytokines in renal cancer

31 March 2020

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Enhancement of anti-tumor activity of recombinant interleukin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2

31 March 2020

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An anti-IL-2 antibody increases serum half-life and improves anti-tumor efficacy of human recombinant interleukin-2

31 March 2020

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IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25

31 March 2020

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Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy

31 March 2020

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Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation.

31 March 2020

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In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy

31 March 2020

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IL-2 complex treatment can protect naive mice from bacterial and viral infection

31 March 2020

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Cutting edge: IL-2 immune complexes as a therapy for persistent virus infection

31 March 2020

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In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance

31 March 2020

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In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

31 March 2020

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

31 March 2020

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Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia

31 March 2020

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Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells

31 March 2020

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

31 March 2020

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Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice

31 March 2020

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The Immune Tolerance Network at 10 years: tolerance research at the bedside

31 March 2020

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Interleukin-2 and regulatory T cells in graft-versus-host disease

31 March 2020

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Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

31 March 2020

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Control of homeostasis of CD8+ memory T cells by opposing cytokines.

31 March 2020

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A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo

31 March 2020

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High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth

31 March 2020

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Induction of interleukin 2 receptor beta chain expression by self-recognition in the thymus

31 March 2020

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Homeostasis of V alpha 14i NKT cells

31 March 2020

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Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells

31 March 2020

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Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

31 March 2020

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12 December 2020

Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS.

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12 December 2020

The role of interleukin-2 in memory CD8 cell differentiation.

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12 December 2020

Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development

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12 December 2020

Human fibroblasts express functional IL-2 receptors formed by the IL-2R alpha- and beta-chain subunits: association of IL-2 binding with secretion of the monocyte chemoattractant protein-1

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12 December 2020

Interleukin 2 receptors on cultured murine epidermal Langerhans cells

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12 December 2020

Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase

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12 December 2020

The fate of interleukin-2 after in vivo administration

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12 December 2020

Identifiers

DOI

10.1038/NRI3156

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31 July 2017

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PubMed ID

22343569