Neuronal P2X7 Receptors Revisited: Do They Really Exist? (Q38659420)

PubMed publication ID

28747388

5 September 2017

title

Neuronal P2X7 Receptors Revisited: Do They Really Exist? (English)

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12 May 2020

author name string

Peter Illes

series ordinal

1

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12 May 2020

Tahir Muhammad Khan

series ordinal

2

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12 May 2020

Patrizia Rubini

series ordinal

3

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12 May 2020

language of work or name

English

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publication date

1 July 2017

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PubMed publication ID

28747388

5 September 2017

published in

Journal of Neuroscience

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12 May 2020

volume

37

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12 May 2020

issue

30

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12 May 2020

page(s)

7049-7062

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P2X7 receptors in Müller glial cells from the human retina

12 May 2020

cites work

1 reference

12 December 2020

Upregulation of P2X(7) receptor currents in Müller glial cells during proliferative vitreoretinopathy.

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12 December 2020

P2 receptors meet the immune system

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12 December 2020

Single GABAergic synaptic terminals from rat midbrain exhibit functional P2X and dinucleotide receptors, able to induce GABA secretion

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12 December 2020

Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems

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12 December 2020

Distribution of P2X receptors on astrocytes in juvenile rat hippocampus

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12 December 2020

P2X receptor expression on astrocytes in the nucleus accumbens of rats

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12 December 2020

Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus

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12 December 2020

Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.

1 reference

12 December 2020

Role of superoxide dismutases in oxidative damage and neurodegenerative disorders

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12 December 2020

Molecular physiology of P2X receptors

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12 December 2020

P2X7 receptor-mediated release of excitatory amino acids from astrocytes.

1 reference

12 December 2020

ATP-induced, sustained calcium signalling in cultured rat cortical astrocytes: evidence for a non-capacitative, P2X7-like-mediated calcium entry

1 reference

12 December 2020

Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors

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12 December 2020

P2X7 receptors in rat brain: presence in synaptic terminals and granule cells.

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12 December 2020

Molecular physiology of P2 receptors in the central nervous system

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12 December 2020

Reanalysis of P2X7 receptor expression in rodent brain

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12 December 2020

P2X7 receptor inhibition improves recovery after spinal cord injury

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12 December 2020

P2X7 receptor expression after ischemia in the cerebral cortex of rats

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12 December 2020

Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP.

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12 December 2020

P2X7-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms

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12 December 2020

ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor

1 reference

12 December 2020

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

1 reference

12 December 2020

Identification and characterization of splice variants of the human P2X7 ATP channel

1 reference

12 December 2020

P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice

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12 December 2020

Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice

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12 December 2020

Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy.

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12 December 2020

Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus

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12 December 2020

Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia

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12 December 2020

Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.

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12 December 2020

Purinergic receptors mediate two distinct glutamate release pathways in hippocampal astrocytes.

1 reference

12 December 2020

P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling

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12 December 2020

Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes

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12 December 2020

Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons

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12 December 2020

P2X7 receptors in the nervous system

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12 December 2020

Regulation of intracellular Ca2+ by P2Y1 receptors may depend on the developmental stage of cultured rat striatal neurons

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12 December 2020

P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro

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12 December 2020

P2X(7) receptors: properties and relevance to CNS function

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12 December 2020

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

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12 December 2020

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12 December 2020

Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia

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12 December 2020

Oxygen/glucose deprivation increases the integration of recombinant P2X7 receptors into the plasma membrane of HEK293 cells

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12 December 2020

Liaisons dangereuses: P2X(7) and the inflammasome.

1 reference

12 December 2020

P2X7 Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis

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12 December 2020

Fluoroacetate and fluorocitrate: mechanism of action

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12 December 2020

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site

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12 December 2020

Synaptic terminals from mice midbrain exhibit functional P2X7 receptor

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12 December 2020

Cellular localization of P2X7 receptor mRNA in the rat brain

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12 December 2020

Purinergic modulation of microglial cell activation

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12 December 2020

Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding.

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12 December 2020

Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels

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12 December 2020

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

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12 December 2020

Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons

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12 December 2020

Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals

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12 December 2020

Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons.

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12 December 2020

Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine

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12 December 2020

Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus

1 reference

12 December 2020

Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.

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12 December 2020

The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release

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12 December 2020

Hemichannels in cerebral ischemia

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12 December 2020

Increase of intracellular Ca2+ by P2X and P2Y receptor-subtypes in cultured cortical astroglia of the rat.

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12 December 2020

Activation of microglia by amyloid {beta} requires P2X7 receptor expression

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12 December 2020

Genetics of the P2X7 receptor and human disease.

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12 December 2020

P2X7 and P2Y13 purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes.

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12 December 2020

A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice.

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12 December 2020

Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes

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12 December 2020

Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat.

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12 December 2020

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

1 reference

12 December 2020

The P2X7 purinergic receptor: from physiology to neurological disorders.

1 reference

12 December 2020

P2X(7) Receptors in Neurological and Cardiovascular Disorders

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12 December 2020

P2X7 receptors mediate ischemic damage to oligodendrocytes.

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12 December 2020

P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide

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12 December 2020

Glutamate-mediated astrocyte-to-neuron signalling in the rat dorsal horn

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12 December 2020

C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation

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12 December 2020

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor

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12 December 2020

Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis.

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12 December 2020

Glial cells and chronic pain

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12 December 2020

Microglia: proliferation and activation driven by the P2X7 receptor

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12 December 2020

Expression and contribution of satellite glial cells purinoceptors to pain transmission in sensory ganglia: an update

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12 December 2020

Electrophysiological classification of P2X7 receptors in rat cultured neocortical astroglia.

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12 December 2020

Rodent cortical astroglia express in situ functional P2X7 receptors sensing pathologically high ATP concentrations.

1 reference

12 December 2020

Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis

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12 December 2020

Experimental characterization and mathematical modeling of P2X7 receptor channel gating.

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12 December 2020

The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein

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12 December 2020

Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors

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12 December 2020

Ion channels on microglia: therapeutic targets for neuroprotection

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12 December 2020

FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

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12 December 2020

C terminus of the P2X7 receptor: treasure hunting.

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12 December 2020

Pannexin channels are not gap junction hemichannels

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12 December 2020

Purinergic signaling involved in Müller cell function in the mammalian retina

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12 December 2020

Purinergic signaling in the cerebellum: Bergmann glial cells express functional ionotropic P2X7 receptors.

1 reference

12 December 2020

Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts

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12 December 2020

Astrocytes are endogenous regulators of basal transmission at central synapses

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12 December 2020

Purinergic signalling: from normal behaviour to pathological brain function

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12 December 2020

Local Ca2+ detection and modulation of synaptic release by astrocytes.

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12 December 2020

Calcium-dependent block of P2X7 receptor channel function is allosteric

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12 December 2020

P2X receptors and their roles in astroglia in the central and peripheral nervous system

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12 December 2020

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases.

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12 December 2020

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

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12 December 2020

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice.

1 reference

12 December 2020

Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation

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12 December 2020

Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury

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12 December 2020

Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus

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12 December 2020

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

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12 December 2020

Pathophysiology of astroglial purinergic signalling

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12 December 2020

Microglial microvesicle secretion and intercellular signaling.

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12 December 2020

Mechanisms of ATP release and signalling in the blood vessel wall

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12 December 2020

Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice

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12 December 2020

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

1 reference

12 December 2020

P2X7 receptors: channels, pores and more

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12 December 2020

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

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12 December 2020

The role of glutamate release mediated by extrasynaptic P2X7 receptors in animal models of neuropathic pain

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12 December 2020

Anoxic depolarization of hippocampal astrocytes: possible modulation by P2X7 receptors

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12 December 2020

A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration

1 reference

12 December 2020

P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration.

1 reference

12 December 2020

The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis.

1 reference

12 December 2020

Is pannexin the pore associated with the P2X7 receptor?

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12 December 2020

Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

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12 December 2020

Block of P2X7 receptors could partly reverse the delayed neuronal death in area CA1 of the hippocampus after transient global cerebral ischemia

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12 December 2020

Purinergic P2X7 receptors mediate cell death in mouse cerebellar astrocytes in culture

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12 December 2020

Introduction and perspective, historical note

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12 December 2020

P2X receptors as targets for the treatment of status epilepticus

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12 December 2020

Role of connexins and pannexins in ischemic stroke

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12 December 2020

Gliotransmitters travel in time and space

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12 December 2020

Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain

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12 December 2020

Astrocyte-neuron interaction in the substantia gelatinosa of the spinal cord dorsal horn via P2X7 receptor-mediated release of glutamate and reactive oxygen species

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12 December 2020

The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease

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12 December 2020

Functional P2X7 receptors at cultured hippocampal astrocytes but not neurons

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12 December 2020

Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons

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12 December 2020

P2X7 receptor: an emerging target in central nervous system diseases

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12 December 2020

Animal models of epilepsy: use and limitations.

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12 December 2020

Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage.

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12 December 2020

Astrocyte-mediated ischemic tolerance

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12 December 2020

ATP as a multi-target danger signal in the brain

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12 December 2020

Purinergic signaling in retinal degeneration and regeneration

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12 December 2020

Neuroglial Transmission

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12 December 2020

Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival

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12 December 2020

Purinergic neurone-glia signalling in cognitive-related pathologies

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12 December 2020

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

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12 December 2020

ATPergic signalling during seizures and epilepsy

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12 December 2020

Purinergic signalling in brain ischemia.

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12 December 2020

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

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12 December 2020

Purinergic Mechanisms and Pain

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12 December 2020

FGF-1 Triggers Pannexin-1 Hemichannel Opening in Spinal Astrocytes of Rodents and Promotes Inflammatory Responses in Acute Spinal Cord Slices

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12 December 2020

The microglial ATP-gated ion channel P2X7 as a CNS drug target

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12 December 2020

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.

1 reference

12 December 2020

Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus

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12 December 2020

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12 December 2020

Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation.

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12 December 2020

X-ray structures define human P2X3 receptor gating cycle and antagonist action

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12 December 2020

Regulation of adult neural progenitor cell functions by purinergic signaling

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12 December 2020

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice.

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12 December 2020

P2X7 receptor-sensitivity of astrocytes and neurons in the substantia gelatinosa of organotypic spinal cord slices of the mouse depends on the length of the culture period.

1 reference

12 December 2020

Extracellular ATP: effects, sources and fate

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12 December 2020

The glutamate analogue alpha-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro.

1 reference

12 December 2020

Altered acidic and basic fibroblast growth factor expression following spinal cord injury

1 reference

12 December 2020

Purinoceptors: are there families of P2X and P2Y purinoceptors?

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12 December 2020

Cloning and functional expression of a brain G-protein-coupled ATP receptor

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12 December 2020

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

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12 December 2020

Tissue distribution of the P2X7 receptor

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12 December 2020

10.1523/JNEUROSCI.3103-16.2017

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6705732&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6705732&resulttype=core&format=json

12 May 2020

PubMed publication ID

28747388

1 reference