Synthetic biology: applying biological circuits beyond novel therapies (Q38679815)

5 September 2017

title

Synthetic biology: applying biological circuits beyond novel therapies (English)

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5 September 2017

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3

Martin Fussenegger

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5 September 2017

Anton Dobrin

1

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5 September 2017

Pratik Saxena

series ordinal

2

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5 September 2017

publication date

24 December 2015

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5 September 2017

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5 September 2017

volume

8

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5 September 2017

issue

4

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5 September 2017

page(s)

409-430

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The expanded genetic alphabet

5 September 2017

cites work

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Precision cancer mouse models through genome editing with CRISPR-Cas9.

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CellNet: network biology applied to stem cell engineering

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Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems

21 January 2018

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Synthetic biology: Construction of a yeast chromosome

21 January 2018

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Novel theranostic agents for next-generation personalized medicine: small molecules, nanoparticles, and engineered mammalian cells

21 January 2018

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CAR therapy: the CD19 paradigm

21 January 2018

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Synthetic Biology--Toward Therapeutic Solutions

21 January 2018

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A brief history of synthetic biology

21 January 2018

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Synthetic biology in cell-based cancer immunotherapy

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Cell encapsulation: technical and clinical advances

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

The use of light for engineered control and reprogramming of cellular functions

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

A detailed predictive model of the mammalian circadian clock

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Distance and helical phase dependence of synergistic transcription activation in cis-regulatory module

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Dynamics and memory of heterochromatin in living cells.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Glucocorticoid receptor transcriptional activity determined by spacing of receptor and nonreceptor DNA sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Transcriptional activation by viral regulatory proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Synthetic design of strong promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Achieving stability of lipopolysaccharide-induced NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Temporally precise in vivo control of intracellular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A quantitative framework for the forward design of synthetic miRNA circuits

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

The genetic design of signaling cascades to record receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

An engineered epigenetic transgene switch in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A genetic time-delay circuitry in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A tunable synthetic mammalian oscillator

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A synthetic low-frequency mammalian oscillator

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Rationally designed logic integration of regulatory signals in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

An engineered mammalian band-pass network

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Synthetic two-way communication between mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

A synthetic time-delay circuit in mammalian cells and mice

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Hysteresis in a synthetic mammalian gene network

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Intron length increases oscillatory periods of gene expression in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

MicroRNA regulation of allergic inflammation and asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Current State of Circulating MicroRNAs as Cancer Biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Three-dimensionally designed protein-responsive RNA devices for cell signaling regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A high-throughput screening system for G-protein-coupled receptors using β-lactamase enzyme complementation technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A synthetic cGMP-sensitive gene switch providing Viagra(®)-controlled gene expression in mammalian cells and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Reward-based hypertension control by a synthetic brain-dopamine interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A designer cell-based histamine-specific human allergy profiler

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A synthetic mammalian gene circuit reveals antituberculosis compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Engineered UV-A light-responsive gene expression system for measuring sun cream efficacy in mammalian cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A review of mitosis in the fission yeast Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

De novo design and construction of an inducible gene expression system in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

The food additive vanillic acid controls transgene expression in mammalian cells and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Cosmetics-triggered percutaneous remote control of transgene expression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

21 January 2018

Engineering allostery

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https://api.crossref.org/works/10.1039%2FC5IB00263J

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Engineering of ribozyme-based riboswitches for mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Monitoring regulated protein-protein interactions using split TEV

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

An inducible caspase 9 safety switch for T-cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Inducible apoptosis as a safety switch for adoptive cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A light-triggered protein secretion system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Optical control of protein activity by fluorescent protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A genetically encoded photoactivatable Rac controls the motility of living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Induction of protein-protein interactions in live cells using light

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Rapid blue-light-mediated induction of protein interactions in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

TULIPs: tunable, light-controlled interacting protein tags for cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A synthetic biology framework for programming eukaryotic transcription functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Split-cre complementation indicates coincident activity of different genes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Photomodulation of protein trans-splicing through backbone photocaging of the DnaE split intein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Conditional protein splicing: a new tool to control protein structure and function in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Small molecule-triggered Cas9 protein with improved genome-editing specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

DNA sense-and-respond protein modules for mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Chemical control of protein stability and function in living mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Small-molecule displacement of a cryptic degron causes conditional protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Effect of the estrous cycle on susceptibility of female mice to intravaginal inoculation of herpes simplex virus type 2 (HSV-2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Self-sufficient control of urate homeostasis in mice by a synthetic circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A tunable dual-promoter integrator for targeting of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Combinatorial gene regulation by modulation of relative pulse timing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Intersectional Cre driver lines generated using split-intein mediated split-Cre reconstitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Protein scaffold-activated protein trans-splicing in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A general design strategy for protein-responsive riboswitches in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Antagonistic control of a dual-input mammalian gene switch by food additives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Engineered lentiviral vector targeting astrocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Higher-order cellular information processing with synthetic RNA devices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Multi-input RNAi-based logic circuit for identification of specific cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Digital switching in a biosensor circuit via programmable timing of gene availability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Multi-chromatic control of mammalian gene expression and signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Orthogonal optogenetic triple-gene control in Mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

A novel reporter system for bacterial and mammalian cells based on the non-ribosomal peptide indigoidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Synthetic memory circuits for tracking human cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Synthetic ecosystems based on airborne inter- and intrakingdom communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Human whole-blood culture system for ex vivo characterization of designer-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Rapamycin and mTOR kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

Expanding the Biologist's Toolkit with CRISPR-Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

The farther, the safer: a manifesto for securely navigating synthetic species away from the old living world

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5IB00263J

21 January 2018

Identifiers

DOI

10.1039/C5IB00263J

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5 September 2017

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