UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization (Q38696038)

5 September 2017

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization (English)

1 reference

5 September 2017

Ryota Nakashima

1

1 reference

5 September 2017

Yoko Goto

2

1 reference

5 September 2017

Sho Koyasu

3

1 reference

5 September 2017

Minoru Kobayashi

4

1 reference

5 September 2017

Akiyo Morinibu

5

1 reference

5 September 2017

Michio Yoshimura

6

1 reference

5 September 2017

Masahiro Hiraoka

7

1 reference

5 September 2017

Ester M Hammond

8

1 reference

5 September 2017

Hiroshi Harada

9

1 reference

5 September 2017

language of work or name

English

0 references

publication date

31 July 2017

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5 September 2017

1 reference

5 September 2017

7

1 reference

5 September 2017

1

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5 September 2017

6879

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Creative Commons Attribution 4.0 International

5 September 2017

start time

31 July 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5537219/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/s41598-017-06605-1

0 references

cites work

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Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance

6 September 2017

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UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

6 September 2017

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Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.

6 September 2017

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6 September 2017

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Regulation of the pentose phosphate pathway in cancer

6 September 2017

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6 September 2017

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6 September 2017

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Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

6 September 2017

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Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

6 September 2017

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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

6 September 2017

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How can we overcome tumor hypoxia in radiation therapy?

6 September 2017

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Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

6 September 2017

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Otto Warburg's contributions to current concepts of cancer metabolism

6 September 2017

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Hallmarks of Cancer: The Next Generation

6 September 2017

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p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

6 September 2017

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Regulation of cancer cell metabolism

6 September 2017

1 reference

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The potential role of ubiquitin c-terminal hydrolases in oncogenesis

6 September 2017

1 reference

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HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery

6 September 2017

1 reference

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Regulation of cancer cell metabolism by hypoxia-inducible factor 1.

6 September 2017

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Regulation of glutathione synthesis

6 September 2017

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Evaluation of HIF-1 inhibitors as anticancer agents

6 September 2017

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Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.

6 September 2017

1 reference

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Clonogenic assay of cells in vitro.

6 September 2017

1 reference

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Radiation and the microenvironment - tumorigenesis and therapy

6 September 2017

1 reference

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Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

6 September 2017

1 reference

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Exploiting tumour hypoxia in cancer treatment

6 September 2017

1 reference

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Combining radiation and molecular targeting in cancer therapy

6 September 2017

1 reference

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Tumor hypoxia: a target for selective cancer therapy

6 September 2017

1 reference

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Targeting HIF-1 for cancer therapy

6 September 2017

1 reference

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

6 September 2017

1 reference

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

6 September 2017

1 reference

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

6 September 2017

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

6 September 2017

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

6 September 2017

1 reference

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

6 September 2017

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

Tumor metabolism: cancer cells give and take lactate

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5537219

Small molecule inhibition of hypoxia inducible factor-1alpha: a viable therapeutic approach?

23 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-017-06605-1

7 January 2021

inferred from DOI database lookup

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-017-06605-1

7 January 2021

inferred from DOI database lookup

Intensity modulated radiation therapy (IMRT): a new promising technology in radiation oncology

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28761052

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41598-017-06605-1

1 reference

Dimensions Publication ID

5 September 2017

1090930107

0 references

Fatcat ID

release_muymxkbgi5hftersqoxc2kpxuq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/muymxkbgi5hftersqoxc2kpxuq

24 November 2022

mapped directly with Wikidata item

1 reference

5 September 2017

PubMed publication ID

28761052

1 reference