Regulation of cancer cell metabolism (Q28303890)

Europe PubMed Central

title

Regulation of cancer cell metabolism (English)

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author name string

Rob A Cairns

series ordinal

1

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Isaac S Harris

series ordinal

2

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Tak W Mak

series ordinal

3

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language of work or name

English

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publication date

February 2011

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published in

Nature Reviews Cancer

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volume

11

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issue

2

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page(s)

85-95

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International network of cancer genome projects

31 March 2020

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An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

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The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells

31 March 2020

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Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

31 March 2020

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On the Origin of Cancer Cells

31 March 2020

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Mitochondria in cancer: not just innocent bystanders

31 March 2020

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Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production

31 March 2020

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Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation

31 March 2020

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

31 March 2020

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Why do cancers have high aerobic glycolysis?

31 March 2020

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Causes and consequences of increased glucose metabolism of cancers

31 March 2020

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Molecular imaging of cancer with positron emission tomography

31 March 2020

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18F-FDG uptake in lung, breast, and colon cancers: molecular biology correlates and disease characterization

31 March 2020

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Positron emission tomography scanning: current and future applications

31 March 2020

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

31 March 2020

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

31 March 2020

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Targeting the PI3K signaling pathway in cancer

31 March 2020

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Akt-dependent transformation: there is more to growth than just surviving

31 March 2020

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Akt stimulates aerobic glycolysis in cancer cells

31 March 2020

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Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition

31 March 2020

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Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

31 March 2020

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FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.

31 March 2020

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The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway

31 March 2020

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Defining the role of mTOR in cancer

31 March 2020

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The impact of O2 availability on human cancer

31 March 2020

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Dysregulation of the TSC-mTOR pathway in human disease

31 March 2020

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The VHL tumor suppressor and HIF: insights from genetic studies in mice

31 March 2020

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The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

31 March 2020

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

31 March 2020

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Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

31 March 2020

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HIF-1: upstream and downstream of cancer metabolism

31 March 2020

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

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Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

31 March 2020

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Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104

31 March 2020

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Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

31 March 2020

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

31 March 2020

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Development of HIF-1 inhibitors for cancer therapy

31 March 2020

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MYC-induced cancer cell energy metabolism and therapeutic opportunities

31 March 2020

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Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

31 March 2020

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The interplay between MYC and HIF in cancer.

31 March 2020

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Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

31 March 2020

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AMP-activated protein kinase and human cancer: cancer metabolism revisited

31 March 2020

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

31 March 2020

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

31 March 2020

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

31 March 2020

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LKB1 modulates lung cancer differentiation and metastasis

31 March 2020

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Somatic LKB1 mutations promote cervical cancer progression

31 March 2020

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AMP-activated protein kinase and cancer

31 March 2020

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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

31 March 2020

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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

31 March 2020

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31 March 2020

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Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53

31 March 2020

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

31 March 2020

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Regulation of PTEN transcription by p53

31 March 2020

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p53 regulates mitochondrial respiration

31 March 2020

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OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells

31 March 2020

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Examination of POU homeobox gene expression in human breast cancer cells

31 March 2020

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Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.

31 March 2020

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Pyruvate kinase type M2 and its role in tumor growth and spreading

31 March 2020

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Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.

31 March 2020

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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

31 March 2020

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

31 March 2020

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

31 March 2020

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

31 March 2020

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SnapShot: Reactive Oxygen Intermediates (ROI)

31 March 2020

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Recurring mutations found by sequencing an acute myeloid leukemia genome

31 March 2020

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IDH1 and IDH2 mutations in gliomas

31 March 2020

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

31 March 2020

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

31 March 2020

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

31 March 2020

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

31 March 2020

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IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors

31 March 2020

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Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

31 March 2020

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Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth

31 March 2020

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Reversible inactivation of the tumor suppressor PTEN by H2O2

31 March 2020

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Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

31 March 2020

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HIF-dependent antitumorigenic effect of antioxidants in vivo

31 March 2020

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Mitochondrial regulation of oxygen sensing

31 March 2020

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ROS as a tumour suppressor?

31 March 2020

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Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

31 March 2020

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Mechanisms of cytochrome c release from mitochondria

31 March 2020

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Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol.

31 March 2020

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Reactive oxygen species: a breath of life or death?

31 March 2020

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Folding and stability of the Z and S(iiyama) genetic variants of human alpha1-antitrypsin

31 March 2020

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Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

31 March 2020

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Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

31 March 2020

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

31 March 2020

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Specific killing of Rb mutant cancer cells by inactivating TSC2.

31 March 2020

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

31 March 2020

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Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

31 March 2020

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MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells.

31 March 2020

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Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers.

31 March 2020

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Proline oxidase functions as a mitochondrial tumor suppressor in human cancers

31 March 2020

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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

31 March 2020

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Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

31 March 2020

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Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

31 March 2020

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

31 March 2020

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

31 March 2020

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Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

31 March 2020

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

31 March 2020

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DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

31 March 2020

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

31 March 2020

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DJ-1, a novel regulator of the tumor suppressor PTEN.

31 March 2020

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Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma

31 March 2020

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DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma.

31 March 2020

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

31 March 2020

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Parkinson's disease and cancer risk: a systematic review and meta-analysis

31 March 2020

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Glutamine metabolism in Ehrlich ascites-carcinoma cells

31 March 2020

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Nutrition needs of mammalian cells in tissue culture

31 March 2020

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

31 March 2020

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

31 March 2020

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

31 March 2020

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13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine

31 March 2020

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Asparagine synthetase chemotherapy

31 March 2020

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Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.

31 March 2020

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The tumor microenvironment and metastatic disease

31 March 2020

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Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

31 March 2020

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Regulation of cancer cell metabolism by hypoxia-inducible factor 1.

31 March 2020

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Hypoxia, HIF1 and glucose metabolism in the solid tumour

31 March 2020

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Hypoxia signalling through mTOR and the unfolded protein response in cancer

31 March 2020

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Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

31 March 2020

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Regulation of autophagy through multiple independent hypoxic signaling pathways.

31 March 2020

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Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

31 March 2020

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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

31 March 2020

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XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

31 March 2020

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Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment

31 March 2020

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Energy metabolism in tumor cells

31 March 2020

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Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

31 March 2020

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Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells

31 March 2020

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12 December 2020

Tumor M2-pyruvate kinase in lung cancer patients: immunohistochemical detection and disease monitoring.

1 reference

12 December 2020

Tumor type M2 pyruvate kinase expression in advanced breast cancer

1 reference

12 December 2020

6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin

1 reference

12 December 2020

The Warburg hypothesis fifty years later

1 reference

12 December 2020

Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation

1 reference

12 December 2020

TUM2-PK (pyruvate kinase type tumor M2), CA19-9 and CEA in patients with benign, malignant and metastasizing pancreatic lesions

1 reference

12 December 2020

Genetic complexity and Parkinson's disease

1 reference

12 December 2020

A tabulated summary of the FDG PET literature.

1 reference

12 December 2020

'The metabolism of tumours': 70 years later

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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12 December 2020

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

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12 December 2020

Identifiers

DOI

10.1038/NRC2981

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

187921

1052273406

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187921

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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