Interleukin 33 is a guardian of barriers and a local alarmin (Q38702558)

5 September 2017

Interleukin 33 is a guardian of barriers and a local alarmin (English)

1 reference

5 September 2017

0 references

Nikolas T Martin

1

1 reference

5 September 2017

Michael U Martin

series ordinal

2

1 reference

5 September 2017

language of work or name

English

0 references

publication date

1 January 2016

1 reference

5 September 2017

1 reference

5 September 2017

17

1 reference

5 September 2017

2

1 reference

5 September 2017

122-131

1 reference

https://scigraph.springernature.com/pub.10.1038/ni.3370

5 September 2017

0 references

cites work

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

1 reference

The interleukin-1 family: back to the future

21 January 2018

1 reference

Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes

21 January 2018

1 reference

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

21 January 2018

1 reference

The interleukin-1 receptor family.

21 January 2018

1 reference

Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells

21 January 2018

1 reference

The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function

21 January 2018

1 reference

T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses

21 January 2018

1 reference

Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.

21 January 2018

1 reference

Disease-associated functions of IL-33: the new kid in the IL-1 family

21 January 2018

1 reference

The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders.

21 January 2018

1 reference

Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease

21 January 2018

1 reference

Interleukin-33 biology with potential insights into human diseases

21 January 2018

1 reference

The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury

21 January 2018

1 reference

The IL-33/ST2 pathway--A new therapeutic target in cardiovascular disease

21 January 2018

1 reference

21 January 2018

IL-33: a Janus cytokine

1 reference

The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases

21 January 2018

1 reference

Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage

21 January 2018

1 reference

Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules

21 January 2018

1 reference

Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation.

21 January 2018

1 reference

The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?

21 January 2018

1 reference

The alarmin IL-33 is a notch target in quiescent endothelial cells

21 January 2018

1 reference

Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain

21 January 2018

1 reference

Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences

21 January 2018

1 reference

Increased IL-33 expression by epithelial cells in bronchial asthma.

21 January 2018

1 reference

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.

21 January 2018

1 reference

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo

21 January 2018

1 reference

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket

21 January 2018

1 reference

Interleukin 33 as a mechanically responsive cytokine secreted by living cells

21 January 2018

1 reference

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation.

21 January 2018

1 reference

The role of the nucleosome acidic patch in modulating higher order chromatin structure

21 January 2018

1 reference

Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial hypertension

21 January 2018

1 reference

The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription

21 January 2018

1 reference

Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation.

21 January 2018

1 reference

Epithelial-derived nuclear IL-33 aggravates inflammation in the pathogenesis of reflux esophagitis.

21 January 2018

1 reference

Expression of IL-33 and its epigenetic regulation in Multiple Sclerosis

21 January 2018

1 reference

21 January 2018

1 reference

Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists

21 January 2018

1 reference

The mouse interleukin (Il)33 gene is expressed in a cell type- and stimulus-dependent manner from two alternative promoters

21 January 2018

1 reference

Identification of constitutively active interleukin 33 (IL-33) splice variant

21 January 2018

1 reference

Regulation of IL-33 expression by IFN-γ and tumor necrosis factor-α in normal human epidermal keratinocytes.

21 January 2018

1 reference

Expression of IL-33 in the epidermis: The mechanism of induction by IL-17.

21 January 2018

1 reference

Evidence for a regulatory loop between IFN-γ and IL-33 in skin inflammation

21 January 2018

1 reference

IFN-γ directly controls IL-33 protein level through a STAT1- and LMP2-dependent mechanism

21 January 2018

1 reference

Interleukin-33 - cytokine of dual function or novel alarmin?

21 January 2018

1 reference

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

21 January 2018

1 reference

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

21 January 2018

1 reference

Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation

21 January 2018

1 reference

Interleukin-33 is biologically active independently of caspase-1 cleavage

21 January 2018

1 reference

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

21 January 2018

1 reference

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

21 January 2018

1 reference

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

21 January 2018

1 reference

Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33.

21 January 2018

1 reference

The enigmatic processing and secretion of interleukin-33.

21 January 2018

1 reference

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

21 January 2018

1 reference

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

21 January 2018

1 reference

Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation

21 January 2018

1 reference

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

21 January 2018

1 reference

Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation

21 January 2018

1 reference

Interleukin-33 increases antibacterial defense by activation of inducible nitric oxide synthase in skin

21 January 2018

1 reference

Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature

21 January 2018

1 reference

Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases

21 January 2018

1 reference

Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.

21 January 2018

1 reference

Altered serum levels of IL-33 in patients with advanced systolic chronic heart failure: correlation with oxidative stress

21 January 2018

1 reference

IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells

21 January 2018

1 reference

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex

21 January 2018

1 reference

The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.

21 January 2018

1 reference

Structural insights into the interaction of IL-33 with its receptors

21 January 2018

1 reference

Special aspects of interleukin-33 and the IL-33 receptor complex

21 January 2018

1 reference

Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation

21 January 2018

1 reference

Negative regulatory receptors of the IL-1 family

21 January 2018

1 reference

Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction

21 January 2018

1 reference

The biology of ST2: the International ST2 Consensus Panel

21 January 2018

1 reference

Soluble ST2--analytical considerations

21 January 2018

1 reference

The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells.

21 January 2018

1 reference

Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen

21 January 2018

1 reference

A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor

21 January 2018

1 reference

Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins

21 January 2018

1 reference

Growth factor-induced delayed early response genes

21 January 2018

1 reference

Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1.

21 January 2018

1 reference

Transcription of the interleukin-1 receptor-related T1 gene is initiated at different promoters in mast cells and fibroblasts

21 January 2018

1 reference

T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function

21 January 2018

1 reference

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

21 January 2018

1 reference

T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.

21 January 2018

1 reference

The alarmin IL-33 promotes regulatory T-cell function in the intestine

21 January 2018

1 reference

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1.

21 January 2018

1 reference

Focal adhesion kinase-mediated activation of glycogen synthase kinase 3β regulates IL-33 receptor internalization and IL-33 signaling

21 January 2018

1 reference

F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation

21 January 2018

1 reference

The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling.

21 January 2018

1 reference

Localisation and trafficking of Toll-like receptors: an important mode of regulation.

21 January 2018

1 reference

Interleukin-33 acts as a pro-inflammatory cytokine and modulates its receptor gene expression in highly metastatic human pancreatic carcinoma cells.

21 January 2018

1 reference

Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein

21 January 2018

1 reference

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

21 January 2018

1 reference

Quantitative phosphoproteomic analysis of IL-33-mediated signaling

21 January 2018

1 reference

IL-33 activates tumor stroma to promote intestinal polyposis.

21 January 2018

1 reference

Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells.

21 January 2018

1 reference

IL-33 is a crucial amplifier of innate rather than acquired immunity

21 January 2018

1 reference

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.

21 January 2018

1 reference

Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma

21 January 2018

1 reference

IL-33 exacerbates antigen-induced arthritis by activating mast cells

21 January 2018

1 reference

Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency

21 January 2018

1 reference

Immune-mediated experimental arthritis in IL-33 deficient mice.

21 January 2018

1 reference

Mast Cells Respond to Cell Injury through the Recognition of IL-33.

21 January 2018

1 reference

Barrier Epithelial Cells and the Control of Type 2 Immunity

21 January 2018

1 reference

Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation

21 January 2018

1 reference

IL-33-activated dendritic cells induce an atypical TH2-type response

21 January 2018

1 reference

IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells

21 January 2018

1 reference

Signaling through FcRγ-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses.

21 January 2018

1 reference

IL-33 broadens its repertoire to affect DC.

21 January 2018

1 reference

IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival.

21 January 2018

1 reference

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.

21 January 2018

1 reference

IL-33 induces skin inflammation with mast cell and neutrophil activation

21 January 2018

1 reference

Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent

21 January 2018

1 reference

Interleukin-33 Triggers B1 Cell Expansion and Its Release of Monocyte/Macrophage Chemoattractants and Growth Factors

21 January 2018

1 reference

IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut.

21 January 2018

1 reference

The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses

21 January 2018

1 reference

Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.

21 January 2018

1 reference

Linking acute infection to chronic lung disease. The role of IL-33-expressing epithelial progenitor cells

21 January 2018

1 reference

Damage-associated molecular patterns stimulate interleukin-33 expression in nasal polyp epithelial cells

21 January 2018

1 reference

TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium

21 January 2018

1 reference

IL-33 is upregulated in colonocytes of ulcerative colitis.

21 January 2018

1 reference

Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines.

21 January 2018

1 reference

Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts.

21 January 2018

1 reference

The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation

21 January 2018

1 reference

IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes.

21 January 2018

1 reference

IL-33 is expressed in human osteoblasts, but has no direct effect on bone remodeling

21 January 2018

1 reference

Induction of IL-33 expression and activity in central nervous system glia

21 January 2018

1 reference

Glia maturation factor induces interleukin-33 release from astrocytes: implications for neurodegenerative diseases

21 January 2018

1 reference

Production and functions of IL-33 in the central nervous system

21 January 2018

1 reference

IL-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-κB and ERK1/2 signaling.

21 January 2018

1 reference

Pathogenic mouse hepatitis virus or poly(I:C) induce IL-33 in hepatocytes in murine models of hepatitis

21 January 2018

1 reference

NKT cells are required to induce high IL-33 expression in hepatocytes during ConA-induced acute hepatitis.

21 January 2018

1 reference

AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites

21 January 2018

1 reference

Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells

21 January 2018

1 reference

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

21 January 2018

1 reference

Expression and regulation of interleukin-33 in human monocytes.

21 January 2018

1 reference

Prostaglandin E(2) enhances IL-33 production by dendritic cells.

21 January 2018

1 reference

IL-33 is produced by mast cells and regulates IgE-dependent inflammation

21 January 2018

1 reference

Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis

21 January 2018

1 reference

12 December 2020

IL-33 enhanced the proliferation and constitutive production of IL-13 and IL-5 by fibrocytes

1 reference

12 December 2020

Deubiquitination and stabilization of IL-33 by USP21.

1 reference

12 December 2020

IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma

1 reference

12 December 2020

IL-33 Activates B1 Cells and Exacerbates Contact Sensitivity

1 reference

12 December 2020

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.

1 reference

12 December 2020

Crystal structure of the cytokine interleukin-1 beta.

1 reference

12 December 2020

Adrenoceptor-mediated enhancement of interleukin-33 production by dendritic cells

1 reference

12 December 2020

IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

1 reference

12 December 2020

Severe neutrophil-dominated inflammation and enhanced myelopoiesis in IL-33-overexpressing CMV/IL33 mice

1 reference

12 December 2020

Novel splice variants of IL-33: differential expression in normal and transformed cells

1 reference

12 December 2020

TRAIL but not FasL and TNFα, regulates IL-33 expression in murine hepatocytes during acute hepatitis

1 reference

12 December 2020

Up-regulation of IL-33 expression in various types of murine cells by IL-3 and IL-4

1 reference

12 December 2020

Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice

1 reference

12 December 2020

Expression and effects of IL-33 and ST2 in allergic bronchial asthma: IL-33 induces eotaxin production in lung fibroblasts

1 reference

12 December 2020

Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members

1 reference

12 December 2020

The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses

1 reference

12 December 2020

T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis

1 reference

12 December 2020

The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors

1 reference

12 December 2020

IL-33-activated dendritic cells are critical for allergic airway inflammation

1 reference

12 December 2020

ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis

1 reference

12 December 2020

Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.3370

1 reference

Dimensions Publication ID

5 September 2017

0 references

1 reference