LIM kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization. (Q38742420)

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scientific article published on 25 August 2011

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English	LIM kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization.	scientific article published on 25 August 2011

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11 February 2020

LIM kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization (English)

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Kazumasa Ohashi

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Sachiko Fujiwara

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Takuya Watanabe

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Hiroshi Kondo

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Tai Kiuchi

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Masaaki Sato

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Kensaku Mizuno

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Journal of Biological Chemistry

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36340-36351

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Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks

1 reference

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Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers.

1 reference

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Slipping or gripping? Fluorescent speckle microscopy in fish keratocytes reveals two different mechanisms for generating a retrograde flow of actin

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A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia

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Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion

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Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin

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Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.

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The lamellipodium: where motility begins

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LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505

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Actin machinery: pushing the envelope.

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Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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1 reference

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11 February 2020

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