α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities (Q38781011)

6 September 2017

title

α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities (English)

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6 September 2017

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extracellular vesicle

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3

Bradley T Hyman

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6 September 2017

5

Martin Ingelsson

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6 September 2017

Xandra O. Breakefield

series ordinal

4

object named as

Xandra O Breakefield

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6 September 2017

Camilla Lööv

1

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6 September 2017

Clemens R Scherzer

series ordinal

2

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6 September 2017

language of work or name

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18 March 2016

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Cellular and Molecular Neurobiology

6 September 2017

published in

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6 September 2017

volume

36

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6 September 2017

issue

3

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6 September 2017

page(s)

437-448

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

6 September 2017

cites work

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https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Defined α-synuclein prion-like molecular assemblies spreading in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Clinical use of novel urine and blood based prostate cancer biomarkers: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Exosomes are released by cultured cortical neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Urinary extracellular vesicles as source of biomarkers in kidney diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Acceleration of α-synuclein aggregation by exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

The role of the LRRK2 gene in Parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Formation of toxic oligomeric alpha-synuclein species in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naïve patients with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Synucleinopathies from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

In vivo gastric detection of α-synuclein inclusions in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Synuclein activates microglia in a model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

γ-Synuclein: seeding of α-synuclein aggregation and transmission between cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Suppression of MAP kinases inhibits microglial activation and attenuates neuronal cell death induced by alpha-synuclein protofibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-015-0317-0

α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies

21 January 2018

1 reference

12 December 2020

Increased DJ-1 in urine exosome of Korean males with Parkinson's disease

1 reference

12 December 2020

Cortical Lewy body pathology in the diagnosis of dementia

1 reference

12 December 2020

The Clearance Mechanism of Chilled Blood Platelets

1 reference

12 December 2020

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

1 reference

12 December 2020

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

1 reference

12 December 2020

10.1007/S10571-015-0317-0

Identifiers

DOI

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Dimensions Publication ID

6 September 2017

1048311139

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