Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression. (Q38797183)

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scientific article published on 8 November 2016

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English	Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.	scientific article published on 8 November 2016

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27 March 2020

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression (English)

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27 March 2020

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27 March 2020

Steven Rosenberg

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Steven A Rosenberg

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27 March 2020

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Maria Parkhurst

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27 March 2020

Anna Pasetto

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27 March 2020

Todd Prickett

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27 March 2020

Jessica S Crystal

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27 March 2020

Paul Robbins

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8 November 2016

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27 March 2020

Clinical Cancer Research

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27 March 2020

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27 March 2020

2491-2505

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27 March 2020

Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay.

1 reference

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12 December 2020

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4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function

1 reference

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12 December 2020

based on heuristic

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In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

1 reference

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12 December 2020

based on heuristic

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4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1.

1 reference

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Dominant TCR-alpha requirements for a self antigen recognition in humans

1 reference

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12 December 2020

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Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses

1 reference

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12 December 2020

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Dominant TCR V alpha usage by virus and tumor-reactive T cells with wide affinity ranges for their specific antigens.

1 reference

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12 December 2020

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High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens

1 reference

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Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach

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12 December 2020

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Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo

1 reference

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12 December 2020

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4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses.

1 reference

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12 December 2020

based on heuristic

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TNF/TNFR family members in costimulation of T cell responses

1 reference

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12 December 2020

based on heuristic

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Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method

1 reference

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12 December 2020

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Design and use of conditional MHC class I ligands.

1 reference

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12 December 2020

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Cancer regression in patients after transfer of genetically engineered lymphocytes

1 reference

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12 December 2020

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Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

1 reference

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12 December 2020

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Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Tumor-specific Th17-polarized cells eradicate large established melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

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NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

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Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans

1 reference

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12 December 2020

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Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

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Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma

1 reference

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12 December 2020

based on heuristic

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Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

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T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Antigen spreading contributes to MAGE vaccination-induced regression of melanoma metastases

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12 December 2020

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Simultaneous isolation of CD8(+) and CD4(+) T cells specific for multiple viruses for broad antiviral immune reconstitution after allogeneic stem cell transplantation

1 reference

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12 December 2020

based on heuristic

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Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

1 reference

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12 December 2020

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Simplified method of the growth of human tumor infiltrating lymphocytes in gas-permeable flasks to numbers needed for patient treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Incorporation of transmembrane hydrophobic mutations in the TCR enhance its surface expression and T cell functional avidity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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Immune epitope database analysis resource

1 reference

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12 December 2020

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Paths to stemness: building the ultimate antitumour T cell.

1 reference

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12 December 2020

based on heuristic

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Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

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MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new cloning and expression system yields and validates TCRs from blood lymphocytes of patients with cancer within 10 days

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profiling the T-cell receptor repertoire of patient with pleural tuberculosis by high-throughput sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of FNA samples for whole-exome sequencing and detection of somatic mutations in breast cancer surgical specimens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput pairing of T cell receptor α and β sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunogenicity of somatic mutations in human gastrointestinal cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA sequences of two inducible T-cell genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27827318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1158/1078-0432.CCR-16-2680

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27 March 2020

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27 March 2020

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27 March 2020

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