Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo (Q38802424)

6 September 2017

Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo (English)

1 reference

6 September 2017

3

Karl-Heinz van Pée

1 reference

6 September 2017

Veit Weichold

1

1 reference

PubMed ID

27059664

6 September 2017

Daniela Milbredt

series ordinal

2

1 reference

PubMed ID

27059664

6 September 2017

language of work or name

English

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publication date

5 April 2016

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Angewandte Chemie International Edition

6 September 2017

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volume

55

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6 September 2017

22

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6 September 2017

6374-6389

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Stereochemistry of the chloroperoxidase active site: crystallographic and molecular-modeling studies.

6 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Implications for the catalytic mechanism of the vanadium-containing enzyme chloroperoxidase from the fungus Curvularia inaequalis by X-ray structures of the native and peroxide form

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Structural investigation of the cofactor-free chloroperoxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Purification and Partial Characterization of Tryptophan 7-Halogenase (PrnA) from Pseudomonas fluorescens This work was supported by the Deutsche Forschungsgemeinschaft (DFG) through the Graduiertenkolleg "Struktur-Eigenschafts-Beziehungen bei Hetero

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Analysis of the syrB and syrC genes of Pseudomonas syringae pv. syringae indicates that syringomycin is synthesized by a thiotemplate mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

The biosynthetic gene cluster for coronamic acid, an ethylcyclopropyl amino acid, contains genes homologous to amino acid-activating enzymes and thioesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

The 2-His-1-carboxylate facial triad: a versatile platform for dioxygen activation by mononuclear non-heme iron(II) enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Biochemistry: biosynthesis of an organofluorine molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Mechanism of Enzymatic Fluorination in Streptomyces c attleya

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

The fluorinase from Streptomyces cattleya is also a chlorinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Flavin-dependent halogenases involved in secondary metabolism in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Defects in the synthetic pathway prevent DIF-1 mediated stalk lineage specification cascade in the non-differentiating social amoeba, Acytostelium subglobosum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Cloning and characterization of the biosynthetic gene cluster for kutznerides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Biosynthesis of halogenated metabolites by bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Biosynthesis of the marine antibiotic pentabromopseudilin. 2. The pyrrole ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

The thioesterase Bhp is involved in the formation of beta-hydroxytyrosine during balhimycin biosynthesis in Amycolatopsis balhimycina

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Identification and characterization of a welwitindolinone alkaloid biosynthetic gene cluster in the stigonematalean Cyanobacterium Hapalosiphon welwitschii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

A new family of iron-dependent halogenases acts on freestanding substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

A stereoselective vanadium-dependent chloroperoxidase in bacterial antibiotic biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Structure and action of the myxobacterial chondrochloren halogenase CndH: a new variant of FAD-dependent halogenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Biosynthesis of the dichloroacetyl component of chloramphenicol in Streptomyces venezuelae ISP5230: genes required for halogenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin-aspartate bond

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Integrating carbon-halogen bond formation into medicinal plant metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Gene expression enabling synthetic diversification of natural products: chemogenetic generation of pacidamycin analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[¹⁸F]fluoro-5-deoxyribose as a novel tracer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Regioselective arene halogenation using the FAD-dependent halogenase RebH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Enzymatic halogenation of tryptophan on a gram scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

A high-throughput assay for arylamine halogenation based on a peroxidase-mediated quinone-amine coupling with applications in the screening of enzymatic halogenations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

A flavin-dependent tryptophan 6-halogenase and its use in modification of pyrrolnitrin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Änderung der Regioselektivität der Tryptophan-7-Halogenase PrnA durch ortsspezifische Mutagenese

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201509573

Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.39.259

Identifiers

DOI

10.1002/ANIE.201509573

1 reference

6 September 2017

1 reference

PubMed ID

27059664