Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1). (Q38814423)

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review article

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Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) (English)

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part of the series

Gene Wiki Review Series

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Sheng-Xiang Lin

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author name string

Wanhong He

1

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Misra Gauri

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Ruixuan Wang

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English

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publication date

19 April 2016

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volume

588

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issue

1

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54-61

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Human Estrogenic 17β-Hydroxysteroid Dehydrogenase: Predominance of Estrone Reduction and Its Induction by NADPH

2 April 2020

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Involvement of up-regulation of 17beta-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers

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Rapid purification yielding highly active 17β-hydroxysteroid dehydrogenase: application of hydrophobic interaction and affinity fast protein liquid chromatography

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Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation

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Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer

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From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response

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Genetic variation in the HSD17B1 gene and risk of prostate cancer

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Evaluation of inhibitors for 17beta-hydroxysteroid dehydrogenase type 1 in vivo in immunodeficient mice inoculated with MCF-7 cells stably expressing the recombinant human enzyme.

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12 December 2020

Active site analysis of 17beta-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT.

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12 December 2020

Structure and function of human 17beta-hydroxysteroid dehydrogenases

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12 December 2020

Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies

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Vasomotor symptom prevalence is associated with polymorphisms in sex steroid-metabolizing enzymes and receptors

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The association of genetic polymorphisms in sex hormone biosynthesis and action with insulin sensitivity and diabetes mellitus in women at midlife

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Cognitive functioning and sex steroid hormone gene polymorphisms in women at midlife

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Immunohistochemical localization of 17 beta-hydroxysteroid dehydrogenase in the human endometrium during the menstrual cycle

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Cofactors, redox state, and directional preferences of hydroxysteroid dehydrogenases

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Evaluation of Genetic Variations in the Androgen and Estrogen Metabolic Pathways as Risk Factors for Sporadic and Familial Prostate Cancer

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In situ production of sex steroids in human breast carcinoma

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Intracrinology of estrogens and androgens in breast carcinoma

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Oestrogen producing enzymes and mammary carcinogenesis: a review

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Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.

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12 December 2020

17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.

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12 December 2020

Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

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12 December 2020

Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent d

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12 December 2020

Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis

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12 December 2020

Relative involvement of three 17beta-hydroxysteroid dehydrogenases (types 1, 7 and 12) in the formation of estradiol in various breast cancer cell lines using selective inhibitors

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12 December 2020

Reductive 17beta-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer

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12 December 2020

17Beta-hydroxysteroid dehydrogenase enzymes and breast cancer

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12 December 2020

Advances in development of inhibitors of 17beta hydroxysteroid dehydrogenases

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12 December 2020

Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1.

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12 December 2020

New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity

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12 December 2020

Cell proliferation regulated by estradiol receptor: Therapeutic implications.

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12 December 2020

Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy

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12 December 2020

Novel hydroxysteroid (17beta) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice

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12 December 2020

17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production

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12 December 2020

17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review

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12 December 2020

Insights in 17beta-HSD1 enzyme kinetics and ligand binding by dynamic motion investigation

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12 December 2020

Contribution to the development of inhibitors of 17β-hydroxysteroid dehydrogenase types 1 and 7: key tools for studying and treating estrogen-dependent diseases

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12 December 2020

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

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12 December 2020

Sex steroid receptors in human lung diseases

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12 December 2020

Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol

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12 December 2020

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12 December 2020

The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells

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12 December 2020

17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration

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12 December 2020

A new nonestrogenic steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type I blocks the estrogen-dependent breast cancer tumor growth induced by estrone

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A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study.

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Intratumoral localization and activity of 17β-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: a potent prognostic factor

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Discovery of a non-estrogenic irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 from 3-substituted-16β-(m-carbamoylbenzyl)-estradiol derivatives.

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6-Hydroxybenzothiophene ketones: potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) owing to favorable molecule geometry and conformational preorganization

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12 December 2020

Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells

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12 December 2020

Importance of estrogen sulfates in breast cancer

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12 December 2020

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12 December 2020

The hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate by MCF-7 human breast cancer cells

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Human placental 17 beta-estradiol dehydrogenase. V. Purification and partial characterization of the diphosphopyridine nucleotide (triphosphopyridine nucleotide)-linked enzyme.

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In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway

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Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function.

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Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020)

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12 December 2020

Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution

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12 December 2020

Site-directed mutagenesis of the putative active site of human 17 beta-hydroxysteroid dehydrogenase type 1.

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12 December 2020

Crystallization and Preliminary X-ray Diffraction Analysis of the Complex of Human Placental 17β-Hydroxysteroid Dehydrogenase with NADP+

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Role of 17 beta-hydroxysteroid dehydrogenase type 1 in endocrine and intracrine estradiol biosynthesis

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12 December 2020

Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients

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12 December 2020

Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol

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12 December 2020

The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors

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12 December 2020

Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase.

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12 December 2020

Molecular endocrinology of hydroxysteroid dehydrogenases

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12 December 2020

10.1016/J.GENE.2016.04.031

Identifiers

DOI

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2 April 2020

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2 April 2020

PubMed publication ID

27102893

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